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Ontology Browser

5'-flap endonuclease activity (GO:0017108)
Annotations: Rat: (8) Mouse: (7) Human: (8) Chinchilla: (7) Bonobo: (7) Dog: (7) Squirrel: (0) Pig: (7)
Parent Terms Term With Siblings Child Terms
3'-flap endonuclease activity  
5'-flap endonuclease activity  
Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis.
CC-preferring endodeoxyribonuclease activity 
class II DNA-(apurinic or apyrimidinic site) endonuclease activity 
deoxyribonuclease I activity  
deoxyribonuclease IV (phage-T4-induced) activity 
deoxyribonuclease V activity 
type I site-specific deoxyribonuclease activity 
type II site-specific deoxyribonuclease activity 
type III site-specific deoxyribonuclease activity 

Xrefs: reactome:R-HSA-110363 "FEN1 bound to PCNA and APEX1 cleaves flap ssDNA" ;   reactome:R-HSA-174446 "Removal of remaining Flap from the C-strand" ;   reactome:R-HSA-5651782 "FEN1 bound to POLB cleaves displaced DNA strand (flap)" ;   reactome:R-HSA-5687664 "FEN1 cleaves displaced ssDNA flaps during MMEJ" ;   reactome:R-HSA-69152 "Removal of remaining Flap"
Definition Sources: PMID:9778254

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.