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Ontology Browser

Parent Terms Term With Siblings Child Terms
Sin3-type complex +     
Rpd3L complex 
Rpd3S/Clr6-CII complex 
Sin3 complex  
A multiprotein complex that functions broadly in eukaryotic organisms as a transcriptional repressor of protein-coding genes, through the gene-specific deacetylation of histones. Amongst its subunits, the Sin3 complex contains Sin3-like proteins, and a number of core proteins that are shared with the NuRD complex (including histone deacetylases and histone binding proteins). The Sin3 complex does not directly bind DNA itself, but is targeted to specific genes through protein-protein interactions with DNA-binding proteins.

Definition Sources: PMID:10589671, PMID:11743021, PMID:12865422

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.