The chemical reactions and pathways resulting in the formation of a 2'-deoxyribonucleotide, a compound consisting of 2'-deoxyribonucleoside (a base linked to a 2'-deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
2-deoxyribose 1-phosphate biosynthetic process
deoxyribose 1,5-bisphosphate biosynthetic process
purine deoxyribonucleotide metabolic process +
pyrimidine deoxyribonucleotide metabolic process +