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Term:
Parent Terms Term With Siblings Child Terms
(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity 
(RS)-norcoclaurine 6-O-methyltransferase activity 
(S)-coclaurine-N-methyltransferase activity 
(S)-scoulerine 9-O-methyltransferase activity 
(S)-tetrahydroprotoberberine N-methyltransferase activity 
10-hydroxydihydrosanguinarine 10-O-methyltransferase activity 
11-O-demethyl-17-O-deacetylvindoline O-methyltransferase activity 
12-hydroxydihydrochelirubine 12-O-methyltransferase activity 
16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase activity 
2-methyl-6-phytyl-1,4-benzoquinone methyltransferase activity 
2-methyl-6-solanyl-1,4-benzoquinone methyltransferase activity 
24-methylenesterol C-methyltransferase activity 
3'-demethylstaurosporine O-methyltransferase activity 
3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase activity 
3,5-dichloro-THPH methyl transferase activity 
3,7-dimethylquercitin 4'-O-methyltransferase activity 
3-demethylubiquinol 3-O-methyltransferase activity  
3-demethylubiquinone 3-O-methyltransferase activity  
3-hydroxyanthranilate 4-C-methyltransferase activity 
3-methylquercitin 7-O-methyltransferase activity 
5-hydroxyfuranocoumarin 5-O-methyltransferase activity 
5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity 
6-hydroxymellein O-methyltransferase activity 
6-O-methylnorlaudanosoline 5'-O-methyltransferase activity 
8-hydroxyfuranocoumarin 8-O-methyltransferase activity 
8-hydroxyquercitin 8-O-methyltransferase activity 
[cytochrome c]-methionine S-methyltransferase activity 
[ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity 
acetylserotonin O-methyltransferase activity  
amine N-methyltransferase activity  
anthranilate N-methyltransferase activity 
apigenin 4'-O-methyltransferase activity 
arginine N-methyltransferase activity +   
arsenite methyltransferase activity  
betaine-homocysteine S-methyltransferase activity  
caffeoyl-CoA O-methyltransferase activity 
carnosine N-methyltransferase activity  
catechol O-methyltransferase activity  
chlorophenol O-methyltransferase activity 
columbamine O-methyltransferase activity 
cycloartenol 24-C-methyltransferase activity 
cyclopropane-fatty-acyl-phospholipid synthase activity 
demethylmacrocin O-methyltransferase activity 
dimethylglycine N-methyltransferase activity 
diphthine methyl ester synthase activity  
diphthine synthase activity 
DNA (cytosine-5-)-methyltransferase activity +   
farnesoic acid O-methyltransferase activity 
fatty acid O-methyltransferase activity 
flavone 3'-O-methyltransferase activity 
glucuronoxylan 4-O-methyltransferase activity 
glycine N-methyltransferase activity  
guanidinoacetate N-methyltransferase activity  
histamine N-methyltransferase activity  
indolepyruvate C-methyltransferase activity 
inositol 1-methyltransferase activity 
inositol 3-methyltransferase activity 
inositol 4-methyltransferase activity 
iodophenol O-methyltransferase activity 
isobutyraldoxime O-methyltransferase activity 
isoflavone 4'-O-methyltransferase activity 
isoflavone 7-O-methyltransferase activity 
isoliquiritigenin 2'-O-methyltransferase activity 
isoorientin 3'-O-methyltransferase activity 
kaempferol 4'-O-methyltransferase activity 
L-histidine N(alpha)-methyltransferase activity 
laricitrin 5'-O-methyltransferase activity 
licodione 2'-O-methyltransferase activity 
lipid A phosphate methyltransferase activity 
loganate O-methyltransferase activity 
lysine N-methyltransferase activity +   
macrocin O-methyltransferase activity 
magnesium protoporphyrin IX methyltransferase activity 
methionine S-methyltransferase activity 
methionine synthase activity  
methyl jasmonate methylesterase activity 
methylated-DNA-[protein]-cysteine S-methyltransferase activity  
methylene-fatty-acyl-phospholipid synthase activity 
methylquercetagetin 6-O-methyltransferase activity 
mRNA methyltransferase activity +   
myricetin 3'-O-methyltransferase activity 
N-benzoyl-4-hydroxyanthranilate 4-O-methyltransferase activity 
N-terminal protein N-methyltransferase activity  
nicotinamide N-methyltransferase activity  
nicotinate N-methyltransferase activity 
O-demethylpuromycin O-methyltransferase activity 
phenol O-methyltransferase activity 
phenylethanolamine N-methyltransferase activity  
phosphatidyl-N-methylethanolamine N-methyltransferase activity  
phosphatidylethanolamine N-methyltransferase activity  
phosphoethanolamine N-methyltransferase activity 
polyprenyldihydroxybenzoate methyltransferase activity  
polysaccharide O-methyltransferase activity 
precorrin-2 C20-methyltransferase activity 
precorrin-3B C17-methyltransferase activity 
precorrin-4 C11-methyltransferase activity 
precorrin-6Y C5,15-methyltransferase (decarboxylating) activity 
protein C-terminal leucine carboxyl O-methyltransferase activity  
protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity  
protein-arginine C-methyltransferase activity 
protein-cysteine methyltransferase activity  
protein-glutamate O-methyltransferase activity  
protein-glutamine N-methyltransferase activity +   
protein-L-histidine N-pros-methyltransferase activity  
protein-L-histidine N-tele-methyltransferase activity  
protein-L-isoaspartate (D-aspartate) O-methyltransferase activity  
putrescine N-methyltransferase activity 
pyridine N-methyltransferase activity  
quercetin 3-O-methyltransferase activity 
RNA 5'-gamma-phosphate methyltransferase activity  
RNA cap trimethylguanosine synthase activity  
rRNA methyltransferase activity +   
S-adenosylmethionine-homocysteine S-methyltransferase activity  
S-methylmethionine-homocysteine S-methyltransferase activity  
sarcosine N-methyltransferase activity 
site-specific DNA-methyltransferase (adenine-specific) activity  
site-specific DNA-methyltransferase (cytosine-N4-specific) activity 
sterol 24-C-methyltransferase activity 
tellurite methyltransferase activity 
tetrahydrocolumbamine 2-O-methyltransferase activity 
tetrahydromethanopterin S-methyltransferase activity 
thetin-homocysteine S-methyltransferase activity 
thioether S-methyltransferase activity  
thiol S-methyltransferase activity  
thiopurine S-methyltransferase activity  
Catalysis of the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether.
trans-aconitate 2-methyltransferase activity 
trans-aconitate 3-methyltransferase activity 
tRNA (5-methylaminomethyl-2-thiouridylate)(34)-methyltransferase activity 
tRNA (adenine) methyltransferase activity +   
tRNA (cytidine) methyltransferase activity +   
tRNA (guanine) methyltransferase activity +   
tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent  
tryptophan 2-C-methyltransferase activity 
tyramine N-methyltransferase activity 
uroporphyrin-III C-methyltransferase activity 
vitexin 2''-O-rhamnoside 7-O-methyltransferase activity 

Synonyms
Related Synonyms: 6-thiopurine transmethylase activity ;   S-adenosyl-L-methionine:thiopurine S-methyltransferase activity ;   TPMT ;   mercaptopurine methyltransferase activity ;   thiopurine methyltransferase activity
Xrefs: EC:2.1.1.67 ;   MetaCyc:THIOPURINE-S-METHYLTRANSFERASE-RXN ;   Reactome:R-HSA-5603379 "TPMT does not transfer CH3 from AdoMet to 6MP" ;   Reactome:R-HSA-9748979 "TPMT transfers methyl group to 6TIMP, forming 6MeTIMP" ;   Reactome:R-HSA-9748983 "TPMT transfers methyl group to 6MP, forming 6MeMP" ;   reactome:R-HSA-158609 "TPMT transfers CH3 from AdoMet to 6MP"
Definition Sources: EC:2.1.1.67

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