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Ontology Browser
Term:
Parent Terms Term With Siblings Child Terms
MAPK cascade +     
ERK1 and ERK2 cascade +   
ERK5 cascade +   
JNK cascade +   
A MAPK cascade containing at least the JNK (MAPK8) MAP kinase. It starts with the activation of JUN3K (a MAPK3K), which activates JNKK a MAP2K), which in turn activates JNK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The JNK cascade is activated by stress signals, as well as by G protein-coupled receptors, growth factors, and cytokines, and results in cellular responses such as cell proliferation, cell differentiation, apoptosis and inflammation.
negative regulation of MAPK cascade +   
p38MAPK cascade +   
pheromone response MAPK cascade +  
positive regulation of MAPK cascade +   
regulation of MAPK cascade +   
stress-activated MAPK cascade +   

Synonyms
Exact Synonyms: c-Jun N-terminal kinase cascade
Narrow Synonyms: JNK1 cascade ;   JNK2 cascade ;   JNK3 cascade ;   MAPK10 cascade ;   MAPK8 cascade ;   MAPK9 cascade
Broad Synonyms: SAPK cascade ;   stress-activated protein kinase cascade
Definition Sources: PMID:11790549, PMID:20811974, PMID:23125017

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