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Term:
Parent Terms Term With Siblings Child Terms
base-excision repair, AP site formation +   
The formation of an AP site, a deoxyribose sugar with a missing base, by DNA glycosylase which recognizes an altered base in DNA and catalyzes its hydrolytic removal. This sugar phosphate is the substrate recognized by the AP endonuclease, which cuts the DNA phosphodiester backbone at the 5' side of the altered site to leave a gap which is subsequently repaired.
base-excision repair, gap-filling  
chromosomal 5-methylcytosine DNA demethylation pathway +   
DNA biosynthetic process +   
DNA catabolic process +   
DNA damage tolerance +   
DNA double-strand break processing +   
DNA integration  
DNA modification +   
DNA protection  
DNA recombination +   
DNA repair +   
DNA replication +   
DNA replication initiation +   
DNA replication termination +   
DNA replication, Okazaki fragment processing +   
DNA strand displacement +   
DNA strand elongation +   
DNA strand invasion +   
DNA strand resection involved in replication fork processing +   
DNA topological change  
DNA-templated DNA replication maintenance of fidelity +   
formation of extrachromosomal circular DNA +   
G-quadruplex DNA formation  
gap filling involved in double-strand break repair via nonhomologous end joining 
heteroduplex formation +  
lagging strand initiation 
maintenance of DNA repeat elements +   
meiotic DNA double-strand break formation +   
mitochondrial DNA metabolic process +   
negative regulation of base-excision repair 
negative regulation of DNA metabolic process +   
nucleotide-excision repair, DNA gap filling  
plastid DNA metabolic process +  
positive regulation of base-excision repair  
positive regulation of DNA metabolic process +   
regulation of base-excision repair +   
regulation of DNA metabolic process +   
removal of nonhomologous ends +  
resolution of DNA recombination intermediates +   
telomere maintenance +   
telomere maintenance via base-excision repair  

Synonyms
Xrefs: Reactome:R-HSA-73929 "Base-Excision Repair, AP Site Formation"
Definition Sources: ISBN:0815316194

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