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protein serine/threonine kinase activity (GO:0004674)
Annotations: Rat: (430) Mouse: (440) Human: (450) Chinchilla: (298) Bonobo: (299) Dog: (401) Squirrel: (298) Pig: (397)
Parent Terms Term With Siblings Child Terms
[3-methyl-2-oxobutanoate dehydrogenase (acetyl-transferring)] kinase activity  
[acetyl-CoA carboxylase] kinase activity  
[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity  
[isocitrate dehydrogenase (NADP+)] kinase activity 
[tyrosine 3-monooxygenase] kinase activity 
beta-adrenergic receptor kinase activity  
calcium-dependent protein kinase activity +   
cyclin-dependent protein kinase activating kinase activity  
cyclin-dependent protein kinase activity +   
dephospho-[reductase kinase] kinase activity 
histidine phosphotransfer kinase activity 
histone kinase activity +   
protein arginine kinase activity 
protein histidine kinase activity +   
protein kinase activity involved in regulation of protein localization to cell division site involved in cytokinesis 
protein serine kinase activity (using GTP as donor)  
protein serine/threonine kinase activity +   
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine/threonine/tyrosine kinase activity +   
protein tyrosine kinase activity +   
pyruvate dehydrogenase (acetyl-transferring) kinase activity  
rhodopsin kinase activity  
tau-protein kinase activity  
transmembrane receptor protein kinase activity +   
tropomyosin kinase activity 

Narrow Synonyms: protein kinase (phosphorylating) activity ;   protein phosphokinase activity ;   protein serine kinase activity ;   serine kinase activity ;   serine-specific protein kinase activity ;   threonine-specific protein kinase activity
Alternate IDs: GO:0004695 ;   GO:0004696 ;   GO:0004700
Xrefs: EC:2.7.11 ;   Reactome:R-HSA-109822 "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1" ;   Reactome:R-HSA-109823 "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2" ;   Reactome:R-HSA-111970 "PKC phosphorylates GRK2" ;   Reactome:R-HSA-112381 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex" ;   Reactome:R-HSA-1362270 "Phosphorylation of LIN52 component of MuvB by DYRK1A" ;   Reactome:R-HSA-139908 "Phosphorylation of DLC2 by MAPK8" ;   Reactome:R-HSA-139918 "Phosphorylation of BIM by JNK" ;   Reactome:R-HSA-156682 "PLK1 phosphorylates NUDC" ;   Reactome:R-HSA-1632857 "ULK1 phosphorylates AMBRA1:BECN1 complex" ;   Reactome:R-HSA-164151 "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer" ;   Reactome:R-HSA-165692 "Phosphorylation of 4E-BP1 by activated mTORC1" ;   Reactome:R-HSA-165718 "mTORC1 phosphorylation of RPS6KB1 (S6K)" ;   Reactome:R-HSA-165726 "Phosphorylation of Ribosomal protein S6 by activated S6K1" ;   Reactome:R-HSA-165758 "Phosphorylation and inactivation of eEF2K by activated S6K1" ;   Reactome:R-HSA-165766 "Phosphorylation and activation of eIF4G by activated S6K1" ;   Reactome:R-HSA-165777 "Phosphorylation and activation of eIF4B by activated S6K1" ;   Reactome:R-HSA-166286 "Multiple IRAK1 autophosphorylation steps" ;   Reactome:R-HSA-167084 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex" ;   Reactome:R-HSA-167098 "Phosphorylation (Ser5) of RNA pol II CTD" ;   Reactome:R-HSA-168140 "Phospho-IKK Complex phosphorylates NFkB inhibitor within the NFkB inhibitor:NFkB complex" ;   Reactome:R-HSA-170055 "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes" ;   Reactome:R-HSA-170076 "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes" ;   Reactome:R-HSA-170087 "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes" ;   Reactome:R-HSA-170116 "Myt-1 mediated phosphorylation of Cyclin A:Cdc2" ;   Reactome:R-HSA-170126 "Phosphorylation of Cyclin B1 in the CRS domain" ;   Reactome:R-HSA-187949 "CAK-mediated phosphorylation of Cyclin A:Cdk2" ;   Reactome:R-HSA-188350 "CAK-mediated phosphorylation of Cyclin E:Cdk2" ;   Reactome:R-HSA-195275 "Phosphorylation of APC component of the destruction complex" ;   Reactome:R-HSA-195283 "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3" ;   Reactome:R-HSA-195287 "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3" ;   Reactome:R-HSA-195300 "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3" ;   Reactome:R-HSA-195318 "Phosphorylation of beta-catenin at Ser45 by CK1 alpha" ;   Reactome:R-HSA-201717 "CSNK2-mediated phosphorylation of DVL" ;   Reactome:R-HSA-211583 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197" ;   Reactome:R-HSA-211650 "Autophosphorylation of PAK-2p34 in the activation loop" ;   Reactome:R-HSA-2214351 "PLK1 phosphorylates GORASP1" ;   Reactome:R-HSA-2294580 "PLK1 hyperphosphorylates Condensin II complex" ;   Reactome:R-HSA-2529020 "CK2 phosphorylates condensin I subunits" ;   Reactome:R-HSA-381111 "EIF2AK3 (PERK) phosphorylates EIF2S1 (eIF2-alpha)Phosphorylation of eIF2-alpha by PERK" ;   Reactome:R-HSA-392752 "Phosphorylation of L1 by CK-II" ;   Reactome:R-HSA-442724 "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs)" ;   Reactome:R-HSA-5228811 "NFKBIA variant is not phosphorylated within IkBA:NF-kappaB" ;   Reactome:R-HSA-5607726 "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB" ;   Reactome:R-HSA-5668545 "NIK autophosphorylates on T559" ;   Reactome:R-HSA-6814409 "CK2 phosphorylates PDCL" ;   Reactome:R-HSA-69604 "Phosphorylation of Cdc25A at Ser-123 by Chk1" ;   Reactome:R-HSA-75028 "Phosphorylation of Wee1 kinase by Chk1" ;   Reactome:R-HSA-75809 "Phosphorylation of Cdc25C at Ser216 by CHEK2" ;   Reactome:R-HSA-77071 "Phosphorylation (Ser5) of RNA pol II CTD" ;   Reactome:R-HSA-8868118 "MAPK12 phosphorylates PTPN3" ;   Reactome:R-HSA-8942836 "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6" ;   Reactome:R-HSA-8948039 "FUNDC1 is phosphorylated by CK2" ;   Reactome:R-HSA-8948146 "FUNDC1 is phosphorylated by ULK1 at Ser17" ;   Reactome:R-HSA-918229 "Phosphorylation and release of IRF3/IRF7" ;   Reactome:R-HSA-933525 "Phosphorylation and release of IRF7" ;   Reactome:R-HSA-937059 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex" ;   Reactome:R-HSA-9610153 "Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF" ;   Reactome:R-HSA-9610156 "MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF" ;   Reactome:R-HSA-9610163 "BRAF autophosphorylates downstream of RAP1 and NGF" ;   Reactome:R-HSA-9612501 "SGK phosphorylates CREB1" ;   Reactome:R-HSA-9612509 "SGK phosphorylates SRF" ;   Reactome:R-HSA-9613530 "PRKAA2 phosphorylates PLINs" ;   Reactome:R-HSA-9624526 "AKT phosphorylates FOXO3 downstream of ESR1 and EGFR" ;   Reactome:R-HSA-9632868 "CDKN1B is phosphorylated in response to estrogen" ;   Reactome:R-HSA-9633008 "p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1" ;   Reactome:R-HSA-9633742 "EIF2AK4 (GCN2) dimer autophosphorylates" ;   Reactome:R-HSA-9634702 "LINC01139 promotes phosphorylation of HIF1A by LRRK2" ;   Reactome:R-HSA-9645535 "ALPK1 phosphorylates TIFA" ;   Reactome:R-HSA-9648089 "NEK6 and NEK7 phosphorylate EML4" ;   Reactome:R-HSA-9648883 "p-T-EIF2AK1:ferriheme dimer autophosphorylates" ;   Reactome:R-HSA-9648888 "p-T,T486,T488-EIF2AK1 phosphorylates EIF2S1 (eIF2-alpha)" ;   Reactome:R-HSA-9652165 "MAP2K mutants constitutively phosphorylate MAPKs" ;   Reactome:R-HSA-9653503 "KRAS4B is phosphorylated on serine 181" ;   Reactome:R-HSA-9656214 "MAP2Ks phosphorylate MAPKs downstream of RAF1 mutants" ;   Reactome:R-HSA-9656215 "RAF1 mutant complexes phosphorylate MAP2K dimer" ;   Reactome:R-HSA-9662823 "PLK2, MAPK14 phosphorylate ADAM17" ;   Reactome:R-HSA-9673346 "Unknown kinase phosphorylates p-DVL" ;   Reactome:R-HSA-9681627 "GSK3 phosphorylates N" ;   Reactome:R-HSA-9683664 "GSK3B phosphorylates Ncap" ;   Reactome:R-HSA-975853 "Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR" ;   Reactome:R-HSA-975861 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex" ;   Reactome:R-HSA-975874 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex" ;   Reactome:R-HSA-975878 "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR" ;   reactome:R-HSA-109702 "PDPK1 phosphorylates AKT2" ;   reactome:R-HSA-109860 "MAP2K1 phosphorylates MAPK3" ;   reactome:R-HSA-109862 "MAP2K2 phosphorylates MAPK1" ;   reactome:R-HSA-111919 "PKA phosphorylates CREB1" ;   reactome:R-HSA-112342 "Inactivation of MAP2K1 by CDK1" ;   reactome:R-HSA-1168635 "PRKCB (PKC-beta) phosphorylates CARMA1" ;   reactome:R-HSA-1168638 "Activated IKK phosphorylates I-kappaB" ;   reactome:R-HSA-1168641 "TAK1 associated with the CBM complex phosphorylates IKKbeta" ;   reactome:R-HSA-1181149 "ACVR2A/B (ActRIIA/B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin" ;   reactome:R-HSA-1181156 "Type II Activin Receptor (ActRII/ACVR2) phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in response to NODAL" ;   reactome:R-HSA-1181355 "Phosphorylation of R-SMAD2/3 by NODAL receptor" ;   reactome:R-HSA-1225894 "Type II Activin Receptor (ActRIIB/ACVR2B) phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in response to NODAL" ;   reactome:R-HSA-1358791 "Phosphorylation of USP8 by P-AKT" ;   reactome:R-HSA-1445144 "p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)" ;   reactome:R-HSA-1449597 "p-AKT2 phosphorylates Myosin 5A" ;   reactome:R-HSA-1454699 "AMPK-alpha2 phosphorylates TBC1D1" ;   reactome:R-HSA-1458463 "p-AKT2 phosphorylates RGC2" ;   reactome:R-HSA-1549526 "Phosphorylation of SMAD2/3 by Activin:Activin Receptor" ;   reactome:R-HSA-156673 "Regulation of KIF23 (MKLP1) by phosphorylation" ;   reactome:R-HSA-156678 "Activation of Cdc25C" ;   reactome:R-HSA-156699 "Inactivation of Wee1 kinase" ;   reactome:R-HSA-156723 "Regulation of KIF20A (MKL2) by phosphorylation" ;   reactome:R-HSA-1592233 "p38 MAPK phosphorylates PPARGC1A" ;   reactome:R-HSA-162363 "p-T309,S474-AKT2:PIP3 phosphorylates PDE3B" ;   reactome:R-HSA-162657 "Inactivation of Myt1 kinase" ;   reactome:R-HSA-163010 "Down Regulation of Emi1 through Phosphorylation of Emi1" ;   reactome:R-HSA-163416 "hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP" ;   reactome:R-HSA-163418 "perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP" ;   reactome:R-HSA-1638803 "Phosphorylation of cohesin by PLK1 at centromeres" ;   reactome:R-HSA-165162 "Phosphorylation of TSC2 by PKB" ;   reactome:R-HSA-165182 "Phosphorylation of complexed TSC2 by PKB" ;   reactome:R-HSA-166119 "First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal" ;   reactome:R-HSA-166245 "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex" ;   reactome:R-HSA-166284 "Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP" ;   reactome:R-HSA-168053 "Phosphorylated MAPKs phosphorylate ATF-2" ;   reactome:R-HSA-170977 "FRS2 is phosphorylated by active TrkA receptor" ;   reactome:R-HSA-174119 "Free APC/C phosphorylated by Plk1" ;   reactome:R-HSA-174174 "Phosphorylation of the Emi1 DSGxxS degron by Plk1" ;   reactome:R-HSA-176116 "Recruitment and activation of Chk1" ;   reactome:R-HSA-176298 "Activation of claspin" ;   reactome:R-HSA-187688 "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3" ;   reactome:R-HSA-193647 "IRAK is activated" ;   reactome:R-HSA-193705 "IKKbeta phosphorylates IkB causing NF-kB to dissociate" ;   reactome:R-HSA-198270 "PDPK1 phosphorylates AKT at T308" ;   reactome:R-HSA-198347 "AKT phosphorylates BAD" ;   reactome:R-HSA-198371 "AKT phosphorylates GSK3" ;   reactome:R-HSA-198599 "AKT phosphorylates MDM2" ;   reactome:R-HSA-198609 "AKT phosphorylates TSC2, inhibiting it" ;   reactome:R-HSA-198611 "AKT phosphorylates IKKalpha" ;   reactome:R-HSA-198613 "AKT phosphorylates p21Cip1 and p27Kip1" ;   reactome:R-HSA-198621 "AKT phosphorylates caspase-9" ;   reactome:R-HSA-198640 "TORC2 (mTOR) phosphorylates AKT at S473" ;   reactome:R-HSA-198669 "p38MAPK phosphorylates MSK1" ;   reactome:R-HSA-198731 "ERK1/2 activates ELK1" ;   reactome:R-HSA-198746 "ERK1/2/5 activate RSK1/2/3" ;   reactome:R-HSA-198756 "ERK1/2 phosphorylates MSK1" ;   reactome:R-HSA-199298 "AKT phosphorylates CREB1" ;   reactome:R-HSA-199299 "AKT phosphorylates FOXO transcription factors" ;   reactome:R-HSA-199839 "AKT can phosphorylate RSK" ;   reactome:R-HSA-199863 "AKT can phosphorylate NR4A1 (NUR77)" ;   reactome:R-HSA-199895 "RSK1/2/3 phosphorylates CREB at Serine 133" ;   reactome:R-HSA-199910 "MSK1 activates ATF1" ;   reactome:R-HSA-199917 "MAPKAPK2 phosphorylates CREB at Serine 133" ;   reactome:R-HSA-199929 "ERK5 activates the transcription factor MEF2" ;   reactome:R-HSA-199935 "MSK1 activates CREB" ;   reactome:R-HSA-200143 "AKT phosphorylates AKT1S1 (PRAS40)" ;   reactome:R-HSA-200421 "Activation of cytosolic AMPK by phosphorylation" ;   reactome:R-HSA-201677 "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta" ;   reactome:R-HSA-201691 "Phosphorylation of LRP5/6 cytoplasmic domain by CSNKI" ;   reactome:R-HSA-202222 "Phosphorylation of PKC theta" ;   reactome:R-HSA-202437 "Phosphorylation of CARMA1" ;   reactome:R-HSA-202459 "Phosphorylation of Bcl10" ;   reactome:R-HSA-202500 "Activation of IKK complex" ;   reactome:R-HSA-202510 "Activation of TAK1-TAB2 complex" ;   reactome:R-HSA-202541 "p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB" ;   reactome:R-HSA-2028284 "Phosphorylation of STK4 (MST1) and SAV1 by STK4" ;   reactome:R-HSA-2028555 "Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1)" ;   reactome:R-HSA-2028583 "Phosphorylation of YAP by LATS2" ;   reactome:R-HSA-2028589 "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2)" ;   reactome:R-HSA-2028591 "Phosphorylation of STK3 (MST2) and SAV1 by STK3" ;   reactome:R-HSA-2028598 "Phosphorylation of YAP by LATS1" ;   reactome:R-HSA-2028629 "Phosphorylation of MOB1A and B by p-STK4 (p-MST1)" ;   reactome:R-HSA-2028635 "Phosphorylation of MOB1A and B by p-STK3 (p-MST2)" ;   reactome:R-HSA-2028661 "Phosphorylation of WWTR1 (TAZ) by LATS2" ;   reactome:R-HSA-2028670 "Phosphorylation of MOB1A and B by p-STK4(MST1)/N" ;   reactome:R-HSA-2028673 "Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N" ;   reactome:R-HSA-2028675 "Phosphorylation of MOB1A and B by p-STK3(MST2)/N" ;   reactome:R-HSA-2028679 "Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N" ;   reactome:R-HSA-2029454 "Autophosphorylation of PAK1" ;   reactome:R-HSA-2029460 "PAK1 phosphorylates LIMK1" ;   reactome:R-HSA-2029469 "p-ERK phosphorylates WAVEs and ABI" ;   reactome:R-HSA-2060328 "Phosphorylation of WWTR1 (TAZ) by LATS1" ;   reactome:R-HSA-209087 "IKBA is phosphorylated by Phospho IKKB kinase" ;   reactome:R-HSA-211164 "AKT phosphorylates FOXO1A" ;   reactome:R-HSA-2168079 "MASTL (GWL) phosphorylates ARPP19" ;   reactome:R-HSA-2176475 "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9" ;   reactome:R-HSA-2243938 "AKT1 E17K mutant is phosphorylated by TORC2 complex" ;   reactome:R-HSA-2243942 "PDPK1 phosphorylates AKT1 E17K mutant" ;   reactome:R-HSA-2396007 "IRF3 is phosphorylated by TBK1" ;   reactome:R-HSA-2399941 "AKT1 E17K mutant phosphorylates BAD" ;   reactome:R-HSA-2399966 "AKT1 E17K mutant phosphorylates GSK3" ;   reactome:R-HSA-2399969 "AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1" ;   reactome:R-HSA-2399977 "AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40)" ;   reactome:R-HSA-2399981 "AKT1 E17K mutant phosphorylates MDM2" ;   reactome:R-HSA-2399982 "AKT1 E17K mutant phosphorylates TSC2, inhibiting it" ;   reactome:R-HSA-2399985 "AKT1 E17K mutant phosphorylates caspase-9" ;   reactome:R-HSA-2399988 "AKT1 E17K mutant phosphorylates NR4A1 (NUR77)" ;   reactome:R-HSA-2399992 "AKT1 E17K mutant phosphorylates forkhead box transcription factors" ;   reactome:R-HSA-2399996 "AKT1 E17K mutant phosphorylates CREB1" ;   reactome:R-HSA-2399999 "AKT1 E17K mutant phosphorylates RSK" ;   reactome:R-HSA-2400001 "AKT1 E17K mutant phosphorylates CHUK (IKKalpha)" ;   reactome:R-HSA-2422927 "MAPK3-3 or MAPK1 phosphorylate GORASP2" ;   reactome:R-HSA-2430535 "MASTL phosphorylates ENSA" ;   reactome:R-HSA-2466068 "Phosphorylation of cohesin by PLK1 at chromosomal arms" ;   reactome:R-HSA-2470508 "ACVR2A/B (ActRIIA/B) phosphorylates ACVR1C (ActRIC, ALK7) in response to Activin" ;   reactome:R-HSA-2562526 "PLK1 phosphorylates OPTN" ;   reactome:R-HSA-2574840 "AJUBA facilitates AURKA autophosphorylation" ;   reactome:R-HSA-2730856 "Autophosphorylation of PAK" ;   reactome:R-HSA-2730868 "Phosphorylation of MEK7 by MEKK1" ;   reactome:R-HSA-2730876 "Phosphorylation of IKK-beta by TAK1" ;   reactome:R-HSA-2730896 "Phosphorylation of MEK4 by MEKK1" ;   reactome:R-HSA-2730900 "Activation of TAK1 complex bound to pUb-TRAF6" ;   reactome:R-HSA-2984226 "PLK1 phosphorylates NEK9" ;   reactome:R-HSA-2984258 "NEK9 phosphorylates NEK6/NEK7" ;   reactome:R-HSA-2990880 "NEK6/NEK7 phosphorylates NUP98" ;   reactome:R-HSA-2993898 "VRK1/VRK2 phosphorylate BANF1" ;   reactome:R-HSA-3000310 "AURKA phosphorylates PLK1" ;   reactome:R-HSA-3000327 "PLK1 phosphorylates BORA" ;   reactome:R-HSA-3132737 "MAPKs phosphorylate ETS1 and ETS2" ;   reactome:R-HSA-3209160 "Activated ERKs phosphorylate ERF" ;   reactome:R-HSA-3222006 "STK11 (LKB1) phosphorylates NUAK1" ;   reactome:R-HSA-3222020 "NUAK1 phosphorylates TP53" ;   reactome:R-HSA-3228469 "MAP3K5 phosphorylates MKK3 and MKK6" ;   reactome:R-HSA-3229102 "p-MAPKAPK3 phosphorylates BMI1" ;   reactome:R-HSA-3229152 "MAP3K5 (ASK1) phosphorylates MAP2K4 (SEK1)" ;   reactome:R-HSA-3239014 "MAPKAPK5 phosphorylates TP53" ;   reactome:R-HSA-3239019 "Active p38 MAPK phosphorylates MAPKAPK5" ;   reactome:R-HSA-3249371 "TBK1 phosphorylates STAT6 at Ser407" ;   reactome:R-HSA-3371435 "Constitutive phosphorylation by GSK3" ;   reactome:R-HSA-3371531 "Constitutive phosphorylation by pERK1/2" ;   reactome:R-HSA-3371567 "DBC1 is phosphorylated by ATM/ART" ;   reactome:R-HSA-349426 "Phosphorylation of MDM4 by CHEK2" ;   reactome:R-HSA-349444 "Phosphorylation of COP1 at Ser-387 by ATM" ;   reactome:R-HSA-349455 "Phosphorylation of MDM4 by ATM" ;   reactome:R-HSA-374696 "Phosphorylation of L1 by p90rsk" ;   reactome:R-HSA-3769394 "AKT phosphorylates CBY1" ;   reactome:R-HSA-377186 "Activated Akt1 phosphorylates AKT1S1 (PRAS40)" ;   reactome:R-HSA-3772435 "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL" ;   reactome:R-HSA-380272 "Plk1-mediated phosphorylation of Nlp" ;   reactome:R-HSA-381091 "IRE1 dimer autophosphorylates" ;   reactome:R-HSA-3857328 "RPS6KA1/2/3 phosphorylates CEBPB on S321" ;   reactome:R-HSA-3857329 "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB" ;   reactome:R-HSA-3858480 "WNT-dependent phosphorylation of DVL" ;   reactome:R-HSA-389756 "AKT interacts and phosphorylates Cot" ;   reactome:R-HSA-3928577 "ROCK phosphorylates LIMK1,2" ;   reactome:R-HSA-3928608 "LIMK phosphorylates CFL1, inactivating it" ;   reactome:R-HSA-3928616 "Activated ROCK phosphorylates MRLCs" ;   reactome:R-HSA-3928620 "PAK1 autophosphorylates" ;   reactome:R-HSA-3928625 "PAKs autophosphorylate" ;   reactome:R-HSA-3928640 "PAKs phosphorylate MLC" ;   reactome:R-HSA-399939 "Autophosphorylation of PAK" ;   reactome:R-HSA-399944 "Phosphorylation of CRMPs by Cdk5" ;   reactome:R-HSA-399950 "Phosphorylation of cofilin by LIMK-1" ;   reactome:R-HSA-399951 "Phosphorylation of CRMPs by GSK3beta" ;   reactome:R-HSA-399952 "Phosphorylation of LIMK-1 by PAK" ;   reactome:R-HSA-399978 "Protein kinase C, alpha type phosphorylates MARCKS" ;   reactome:R-HSA-400382 "CSNK1E,CSNK1D phosphorylate CRY and PER proteins" ;   reactome:R-HSA-4088134 "PLK1 phosphorylates FOXM1" ;   reactome:R-HSA-419083 "Myosin phosphatase inactivation by ROCK" ;   reactome:R-HSA-419087 "LIM kinase phosphorylation by ROCK" ;   reactome:R-HSA-419197 "Myosin regulatory light chain phosphorylation by ROCK" ;   reactome:R-HSA-419644 "Transphosphorylation of pLIMK1" ;   reactome:R-HSA-428961 "Phosphorylation of cPLA2 by MAPK p38 alpha" ;   reactome:R-HSA-429016 "ALOX5 is phosphorylated by MAPKAP2" ;   reactome:R-HSA-429714 "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP" ;   reactome:R-HSA-432110 "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding" ;   reactome:R-HSA-4332358 "Dissociation of CaM and CAMK2 autophosphorylation" ;   reactome:R-HSA-4332363 "Autophosphorylation and activation of CAMK2" ;   reactome:R-HSA-4332388 "Activation of MAP3K7 in response to WNT" ;   reactome:R-HSA-4411383 "NLK phosphorylates TCF/LEF" ;   reactome:R-HSA-4411402 "Activation of NLK" ;   reactome:R-HSA-442739 "PDPK1 phosphorylates RSKs" ;   reactome:R-HSA-442832 "PAK phosphorylates cortactin" ;   reactome:R-HSA-445072 "Interaction of PAK1 with Rac1-GTP" ;   reactome:R-HSA-446694 "IRAK4 phosphorylates IRAK1" ;   reactome:R-HSA-446701 "IRAK4-activated IRAK1 autophosphorylates" ;   reactome:R-HSA-448948 "Phosphorylation of E proteins by p38 MAPK" ;   reactome:R-HSA-448955 "Phosphorylation of MEF2 proteins by p38" ;   reactome:R-HSA-450222 "Active p38 MAPK phosphorylates MAPKAPK2 or 3" ;   reactome:R-HSA-450325 "c-FOS activation by phospho ERK1/2" ;   reactome:R-HSA-450463 "MK2 phosphorylates ZFP36 (Tristetraproline, TTP)" ;   reactome:R-HSA-450474 "MK2 phosphorylates BRF1" ;   reactome:R-HSA-450490 "Protein Kinase B/Akt phosphorylates BRF1" ;   reactome:R-HSA-450499 "Protein Kinase B (AKT) phosphorylates KSRP" ;   reactome:R-HSA-450827 "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2." ;   reactome:R-HSA-451152 "MAP kinase p38 phosphorylates KSRP" ;   reactome:R-HSA-451347 "Activation of JNK by DSCAM" ;   reactome:R-HSA-4551570 "VANGL2 is phosphorylated in response to WNT5A" ;   reactome:R-HSA-4608825 "DVL2 is phosphorylated after WNT5A binding to FZD" ;   reactome:R-HSA-4793911 "MAPKAPK2 phosphorylates HSF1" ;   reactome:R-HSA-5082387 "Phosphorylation of HSF1 at Ser230 induces transactivation" ;   reactome:R-HSA-5082405 "Phosphorylation of HSF1 at Ser326 induces transactivation" ;   reactome:R-HSA-5213464 "RIPK1 is phosphorylated" ;   reactome:R-HSA-5213466 "RIPK3 is phosphorylated" ;   reactome:R-HSA-5218814 "PAK2 autophorylates" ;   reactome:R-HSA-5218821 "PDK1 phosphorylates PKC" ;   reactome:R-HSA-5218826 "Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732" ;   reactome:R-HSA-5218854 "p-Y420-FYN is phosphorylated on S21" ;   reactome:R-HSA-5218906 "RIPK3 phosphorylates MLKL" ;   reactome:R-HSA-5218916 "p-MAPK2/3 phosphorylates HSP27" ;   reactome:R-HSA-5229343 "AXIN is phosphorylated in the destruction complex" ;   reactome:R-HSA-5260201 "p-AKT2 phosphorylates C2CD5" ;   reactome:R-HSA-5357472 "PAK1-3 autophosphorylates" ;   reactome:R-HSA-5357477 "PAK1-3 phosphorylates VE-cadherin" ;   reactome:R-HSA-5357831 "CYLD is phosphorylated by IKK" ;   reactome:R-HSA-5578777 "DMPK phosphorylates PLN" ;   reactome:R-HSA-5607722 "Active NIK phosphorylates IKKA dimer" ;   reactome:R-HSA-5607732 "K63polyUb-TAK1 autophosphorylates" ;   reactome:R-HSA-5607742 "K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta" ;   reactome:R-HSA-5610718 "CK1 phosphorylates p-GLI2" ;   reactome:R-HSA-5610722 "CK1 phosphorylates p-GLI3" ;   reactome:R-HSA-5610730 "GSK3 phosphorylates p-GLI2" ;   reactome:R-HSA-5610732 "GSK3 phosphorylates p-GLI3" ;   reactome:R-HSA-5624473 "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit" ;   reactome:R-HSA-5624492 "PAK phosphorylates p21 RAF1 on S338" ;   reactome:R-HSA-5627775 "Autophosphorylation of PAK1,2,3" ;   reactome:R-HSA-5632670 "CSNK1A1 phosphorylates SMO dimer" ;   reactome:R-HSA-5632672 "ADRBK1 phosphorylates SMO dimer" ;   reactome:R-HSA-5635841 "GLI proteins are phosphorylated" ;   reactome:R-HSA-5635842 "ULK3 phosphorylates GLI" ;   reactome:R-HSA-5665868 "AMPK (complex) phosphorylates ULK1 (complex)" ;   reactome:R-HSA-5666160 "AURKB phosphorylates DIAPH2-2 at kinetochores" ;   reactome:R-HSA-5668932 "PAK2 phosphorylates myosin regulatory light chain (MRLC)" ;   reactome:R-HSA-5668947 "PAK1 phosphorylates myosin phosphatase" ;   reactome:R-HSA-5668984 "PAK1 or PAK2 phosphorylates MYLK" ;   reactome:R-HSA-5669250 "PAK1 phosphorylates FLNA" ;   reactome:R-HSA-5671763 "p-T774-PKN1 phosphorylates PPP1R14A" ;   reactome:R-HSA-5671919 "Activated CIT phosphorylates MRLCs" ;   reactome:R-HSA-5672008 "Thr-180 of ULK1 is phosphorylated" ;   reactome:R-HSA-5672010 "Active mTORC1 phosphorylates ULK1" ;   reactome:R-HSA-5672828 "mTORC1 phosphorylates AKT1S1" ;   reactome:R-HSA-5672948 "MARK3 phosphorylates KSR1" ;   reactome:R-HSA-5672973 "MAP2Ks phosphorylate MAPKs" ;   reactome:R-HSA-5672978 "RAF phosphorylates MAP2K dimer" ;   reactome:R-HSA-5674496 "Activated MAPKs phosphorylate MAP2K1" ;   reactome:R-HSA-5675194 "Activated MAPK phosphorylates RAF1" ;   reactome:R-HSA-5675198 "Activated MAPKs phosphorylate BRAF" ;   reactome:R-HSA-5675868 "ULK1 phosphorylates ATG13 and RB1CC1" ;   reactome:R-HSA-5679205 "ULK1 phosphorylates Beclin-1" ;   reactome:R-HSA-5682026 "MRN bound to shortened telomeres activates ATM" ;   reactome:R-HSA-5682101 "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer" ;   reactome:R-HSA-5682598 "ATM phosphorylates HERC2" ;   reactome:R-HSA-5682983 "ATM phosphorylates WHSC1" ;   reactome:R-HSA-5683425 "ATM phosphorylates TP53BP1 at DNA DSBs" ;   reactome:R-HSA-5683792 "p-T68-CHEK2 autophosphorylates" ;   reactome:R-HSA-5683801 "CHEK2 phosphorylates BRCA1" ;   reactome:R-HSA-5683964 "ATM phosphorylates EYA1-4" ;   reactome:R-HSA-5684096 "CDK2 phosphorylates RBBP8" ;   reactome:R-HSA-5684140 "ATM phosphorylates RBBP8" ;   reactome:R-HSA-5684887 "Activation of CHEK1 at resected DNA DSBs" ;   reactome:R-HSA-5685156 "ATR phosphorylates RPA2" ;   reactome:R-HSA-5685230 "CHEK1 phosphorylates RAD51" ;   reactome:R-HSA-5685242 "CHEK1 phosphorylates BRCA2" ;   reactome:R-HSA-5686578 "Activated ATM phosphorylates ABL1" ;   reactome:R-HSA-5686704 "Activated ATM phosphorylates DCLRE1C" ;   reactome:R-HSA-5687086 "PAK1,2,3 phosphorylates MAPK6,4" ;   reactome:R-HSA-5687090 "p-S MAPK6 phosphorylates NCOA3" ;   reactome:R-HSA-5687094 "p-S MAPK6,4 phosphorylate MAPKAPK5" ;   reactome:R-HSA-5687101 "p-T182 MAPKAPK5 phosphorylates FOXO3" ;   reactome:R-HSA-5687121 "p-S MAPKAPK5 phosphorylates HSPB1" ;   reactome:R-HSA-5687183 "PRKDC phosphorylates DCLRE1C at DNA DSBs" ;   reactome:R-HSA-5690250 "p-T182-MAPKAPK5 phoshphorylates DNAJB1" ;   reactome:R-HSA-5692768 "MAPKAPK5 phosphorylates KALRN" ;   reactome:R-HSA-5692775 "SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs" ;   reactome:R-HSA-5692779 "p-S182 MAPKAPK5 phosphorylates FOXO1" ;   reactome:R-HSA-5693536 "ATM phosphorylates MDC1" ;   reactome:R-HSA-5693540 "MRN activates ATM" ;   reactome:R-HSA-5693549 "ATM phosphorylates histone H2AFX on S139 at DNA DSBs" ;   reactome:R-HSA-5693551 "Phosphorylation of BRCA1-A complex at multiple sites by ATM" ;   reactome:R-HSA-5693575 "DNA-PKcs autophosphorylates" ;   reactome:R-HSA-5693598 "ATM phosphorylates NBN" ;   reactome:R-HSA-5693609 "ATM phosphorylates TP53 at S15" ;   reactome:R-HSA-5694441 "CSNK1D phosphorylates SEC23" ;   reactome:R-HSA-6788392 "ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA" ;   reactome:R-HSA-6795290 "TORC2 complex phosphorylates SGK1" ;   reactome:R-HSA-6795460 "SGK1 phosphorylates MDM2" ;   reactome:R-HSA-6795473 "PDPK1 phosphorylates SGK1" ;   reactome:R-HSA-6798372 "ATM phosphorylates DYRK2" ;   reactome:R-HSA-6798374 "DYRK2 phosphorylates TP53" ;   reactome:R-HSA-6799097 "ATM phosphorylates ZNF420" ;   reactome:R-HSA-6799246 "CHEK1 phosphorylates TP53" ;   reactome:R-HSA-6799332 "ATR phosphorylates TP53" ;   reactome:R-HSA-6799409 "HIPK2 phosphorylates TP53" ;   reactome:R-HSA-6800490 "ATM phosphorylates PIDD1" ;   reactome:R-HSA-6801666 "PLK2 phosphorylates CENPJ" ;   reactome:R-HSA-6801675 "PLK2 phosphorylates NPM1" ;   reactome:R-HSA-6802911 "High kinase activity BRAF complexes phosphorylate MAP2Ks" ;   reactome:R-HSA-6802919 "RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks" ;   reactome:R-HSA-6802926 "Mutant RAS:p-RAF complexes phosphorylate MAP2Ks" ;   reactome:R-HSA-6802933 "p-BRAF and RAF fusion dimers phosphorylate MAP2Ks" ;   reactome:R-HSA-6802935 "MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers" ;   reactome:R-HSA-6802943 "RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks" ;   reactome:R-HSA-6802973 "PLK3 phosphorylates CDC25C" ;   reactome:R-HSA-6804266 "CHEK2 phosphorylates TTC5" ;   reactome:R-HSA-6804276 "ATM phosphorylates TTC5" ;   reactome:R-HSA-6804955 "ATM phosphorylates MDM2" ;   reactome:R-HSA-6805059 "CK2:FACT phosphorylates TP53" ;   reactome:R-HSA-6805103 "AURKA phosphorylates TP53" ;   reactome:R-HSA-6805126 "AURKB phosphorylates TP53" ;   reactome:R-HSA-6805276 "CDK5 phosphorylates TP53" ;   reactome:R-HSA-6805285 "PLK3 phosphorylates TP53" ;   reactome:R-HSA-6805399 "TAF1 phosphorylates TP53" ;   reactome:R-HSA-6805479 "TP53RK phosphorylates TP53" ;   reactome:R-HSA-6805640 "AKT phosphorylates KAT6A" ;   reactome:R-HSA-6805785 "AKT phosphorylates PHF20" ;   reactome:R-HSA-6810233 "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter" ;   reactome:R-HSA-6811454 "MAPKs phosphorylate PP2A" ;   reactome:R-HSA-69608 "Phosphorylation of Cdc25A at Ser-123 by Chk2" ;   reactome:R-HSA-69685 "CHEK2 phosphorylates TP53" ;   reactome:R-HSA-69891 "Phosphorylation and activation of CHEK2 by ATM" ;   reactome:R-HSA-75010 "Phosphorylation of Cdc25C at Ser 216 by Chk1" ;   reactome:R-HSA-75820 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta" ;   reactome:R-HSA-8850945 "Casein kinase II phosphorylates PTEN" ;   reactome:R-HSA-8852306 "Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends" ;   reactome:R-HSA-8852317 "PLK1 phosphorylates GTSE1" ;   reactome:R-HSA-8853419 "TPX2 promotes AURKA autophosphorylation" ;   reactome:R-HSA-8853444 "AURKA phosphorylates PHLDA1" ;   reactome:R-HSA-8854908 "PKA phosphorylates RET:GDNF:GFRA dimer" ;   reactome:R-HSA-8856813 "AAK1 phosphorylates AP-2 mu subunit at T156" ;   reactome:R-HSA-8863007 "p25-bound CDK5 phosphorylates CDC25B" ;   reactome:R-HSA-8863011 "p25-bound CDK5 phosphorylates CDC25C" ;   reactome:R-HSA-8863014 "p25-bound CDK5 phosphorylates CDC25A" ;   reactome:R-HSA-8863895 "IKKB phosphorylates SNAP23" ;   reactome:R-HSA-8868260 "CDK5:p25 phosphorylates GOLGA2" ;   reactome:R-HSA-8868340 "CDK5:p25 phosphorylates lamin B1" ;   reactome:R-HSA-8868344 "CDK5:p25 phosphorylates lamin A" ;   reactome:R-HSA-8868567 "CDK5:p25 phosphorylates PRDX1" ;   reactome:R-HSA-8868573 "CDK5:p25 phosphorylates PRDX2" ;   reactome:R-HSA-8868666 "CDK5:p25 phosphorylates JUN" ;   reactome:R-HSA-8870558 "CDK5:p25 phosphorylates FOXO3" ;   reactome:R-HSA-8873929 "Casein kinase II phosphorylates STARD10" ;   reactome:R-HSA-8876446 "p-ULK1 phosphorylates DENND3" ;   reactome:R-HSA-8877691 "MAP2K6 phosphorylates PIP4K2B" ;   reactome:R-HSA-8878050 "HIPK2 phosphorylates RUNX1 and EP300" ;   reactome:R-HSA-8878054 "HIPK2 phosphorylates RUNX1" ;   reactome:R-HSA-8933446 "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling" ;   reactome:R-HSA-8939963 "Activated AKT phosphorylates RUNX2" ;   reactome:R-HSA-8940100 "CDK1 phosphorylates VCPIP1" ;   reactome:R-HSA-8944454 "mTORC1 phosphorylates MAF1" ;   reactome:R-HSA-8948757 "AKT phosphorylates MKRN1" ;   reactome:R-HSA-8952289 "FAM20C phosphorylates FAM20C substrates" ;   reactome:R-HSA-9007539 "CHEK1 phosphorylates E2F6" ;   reactome:R-HSA-9008480 "GSK3B phosphorylates RUNX2" ;   reactome:R-HSA-9008822 "PPM1D dephosphorylates RUNX2" ;   reactome:R-HSA-9009208 "Activated ERKs phosphorylate RUNX2" ;   reactome:R-HSA-9012319 "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD" ;   reactome:R-HSA-9013978 "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex" ;   reactome:R-HSA-9022314 "HIPK2 phosphorylates MECP2" ;   reactome:R-HSA-9023132 "AURKB phosphorylates MECP2 at S423" ;   reactome:R-HSA-9032751 "Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3" ;   reactome:R-HSA-9032863 "CDK5 phosphorylates NTRK2" ;   reactome:R-HSA-912470 "ATR phosphorylates Histone H2A.X at unsynapsed regions" ;   reactome:R-HSA-913996 "PKA/PKG phosphorylate Rap1GAP2" ;   reactome:R-HSA-934559 "SPRY2 is phosphorylated by phosphorylated MNK1" ;   reactome:R-HSA-936951 "Activation of TAK1 complex bound to activated TLR4 complex" ;   reactome:R-HSA-937022 "IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP" ;   reactome:R-HSA-9604328 "AKT1 phosphorylates NOTCH4" ;   reactome:R-HSA-9612980 "BRAF in Rap1-GTP complex:BRAF complex autophosphorylates" ;   reactome:R-HSA-9619515 "AMPK phosphorylates MAPT" ;   reactome:R-HSA-9619843 "ERKs phosphorylate RSKs" ;   reactome:R-HSA-9620004 "RSKs autophosphorylate" ;   reactome:R-HSA-9626880 "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345" ;   reactome:R-HSA-9627089 "CASP9 is phosphorylated at T125" ;   reactome:R-HSA-975125 "Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9" ;   reactome:R-HSA-975134 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9" ;   reactome:R-HSA-975160 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9" ;   reactome:R-HSA-975170 "IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9" ;   reactome:R-HSA-975180 "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9" ;   reactome:R-HSA-975865 "IRAK4 autophosphorylation within the complex activated TLR:MyD88"
Definition Sources: GOC:bf, PMID:2956925

paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.