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Term:
protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity (GO:0004671)
Annotations: Rat: (1) Mouse: (1) Human: (1) Chinchilla: (1) Bonobo: (1) Dog: (2) Squirrel: (1) Pig: (2)
Parent Terms Term With Siblings Child Terms
(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity 
(RS)-norcoclaurine 6-O-methyltransferase activity 
(S)-coclaurine-N-methyltransferase activity 
(S)-scoulerine 9-O-methyltransferase activity 
(S)-tetrahydroprotoberberine N-methyltransferase activity 
10-hydroxydihydrosanguinarine 10-O-methyltransferase activity 
11-O-demethyl-17-O-deacetylvindoline O-methyltransferase activity 
12-hydroxydihydrochelirubine 12-O-methyltransferase activity 
16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase activity 
2-methyl-6-phytyl-1,4-benzoquinone methyltransferase activity 
2-methyl-6-solanyl-1,4-benzoquinone methyltransferase activity 
24-methylenesterol C-methyltransferase activity 
3'-demethylstaurosporine O-methyltransferase activity 
3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase activity 
3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity +   
3,7-dimethylquercitin 4'-O-methyltransferase activity 
3-demethylubiquinol-10 3-O-methyltransferase activity  
3-demethylubiquinone-9 3-O-methyltransferase activity  
3-hydroxyanthranilate 4-C-methyltransferase activity 
3-methylquercitin 7-O-methyltransferase activity 
5-hydroxyfuranocoumarin 5-O-methyltransferase activity 
6-hydroxymellein O-methyltransferase activity 
6-O-methylnorlaudanosoline 5'-O-methyltransferase activity 
8-hydroxyfuranocoumarin 8-O-methyltransferase activity 
8-hydroxyquercitin 8-O-methyltransferase activity 
[cytochrome c]-methionine S-methyltransferase activity 
[ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity 
acetylserotonin O-methyltransferase activity  
amine N-methyltransferase activity  
anthranilate N-methyltransferase activity 
apigenin 4'-O-methyltransferase activity 
arginine N-methyltransferase activity +   
arsenite methyltransferase activity  
caffeoyl-CoA O-methyltransferase activity 
carnosine N-methyltransferase activity  
catechol O-methyltransferase activity  
chlorophenol O-methyltransferase activity 
columbamine O-methyltransferase activity 
cycloartenol 24-C-methyltransferase activity 
cyclopropane-fatty-acyl-phospholipid synthase activity 
demethylmacrocin O-methyltransferase activity 
dimethylglycine N-methyltransferase activity 
dimethylhistidine N-methyltransferase activity 
diphthine synthase activity  
DNA (cytosine-5-)-methyltransferase activity +   
farnesoic acid O-methyltransferase activity 
fatty acid O-methyltransferase activity 
glucuronoxylan 4-O-methyltransferase activity 
glycine N-methyltransferase activity  
guanidinoacetate N-methyltransferase activity  
histamine N-methyltransferase activity  
histidine N-methyltransferase activity 
indolepyruvate C-methyltransferase activity 
inositol 1-methyltransferase activity 
inositol 3-methyltransferase activity 
inositol 4-methyltransferase activity 
iodophenol O-methyltransferase activity 
isobutyraldoxime O-methyltransferase activity 
isoflavone 4'-O-methyltransferase activity 
isoflavone 7-O-methyltransferase activity 
isoliquiritigenin 2'-O-methyltransferase activity 
isoorientin 3'-O-methyltransferase activity 
jasmonate O-methyltransferase activity 
kaempferol 4'-O-methyltransferase activity 
laricitrin 5'-O-methyltransferase activity 
licodione 2'-O-methyltransferase activity 
lipid A phosphate methyltransferase activity 
loganate O-methyltransferase activity 
luteolin O-methyltransferase activity 
lysine N-methyltransferase activity +   
macrocin O-methyltransferase activity 
magnesium protoporphyrin IX methyltransferase activity 
methionine S-methyltransferase activity 
methylarsonite methyltransferase activity  
methylene-fatty-acyl-phospholipid synthase activity 
methylhistidine N-methyltransferase activity 
methylquercetagetin 6-O-methyltransferase activity 
mRNA methyltransferase activity +   
myricetin 3'-O-methyltransferase activity 
N-benzoyl-4-hydroxyanthranilate 4-O-methyltransferase activity 
nicotinamide N-methyltransferase activity  
nicotinate N-methyltransferase activity 
O-demethylpuromycin O-methyltransferase activity 
peptidyl-arginine C-methyltransferase activity 
phenol O-methyltransferase activity 
phenylethanolamine N-methyltransferase activity  
phosphatidyl-N-dimethylethanolamine N-methyltransferase activity  
phosphatidyl-N-methylethanolamine N-methyltransferase activity  
phosphatidylethanolamine N-methyltransferase activity  
phosphoethanolamine N-methyltransferase activity 
phosphomethylethanolamine N-methyltransferase activity 
polysaccharide O-methyltransferase activity 
precorrin-2 C20-methyltransferase activity 
precorrin-3B C17-methyltransferase activity 
precorrin-4 C11-methyltransferase activity 
precorrin-6Y C5,15-methyltransferase (decarboxylating) activity 
protein C-terminal leucine carboxyl O-methyltransferase activity  
protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity  
Catalysis of the reaction: S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester.
protein-glutamate O-methyltransferase activity 
protein-glutamine N-methyltransferase activity +   
protein-histidine N-methyltransferase activity  
protein-L-isoaspartate (D-aspartate) O-methyltransferase activity  
putrescine N-methyltransferase activity 
pyridine N-methyltransferase activity  
quercetin 3-O-methyltransferase activity 
quinone cofactor methyltransferase activity +   
RNA 5'-methyltransferase activity  
rRNA methyltransferase activity +   
S-adenosyl-L-methionine:beta-alanine N-methyltransferase activity  
S-adenosyl-L-methionine:N,N-dimethyl-beta-alanine N-methyltransferase activity 
S-adenosyl-L-methionine:N-methyl-beta-alanine N-methyltransferase activity 
S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity  
S-adenosylmethionine-homocysteine S-methyltransferase activity  
sarcosine N-methyltransferase activity 
site-specific DNA-methyltransferase (adenine-specific) activity  
site-specific DNA-methyltransferase (cytosine-N4-specific) activity 
sterol 24-C-methyltransferase activity 
tellurite methyltransferase activity 
tetrahydrocolumbamine 2-O-methyltransferase activity 
thioether S-methyltransferase activity  
thiol S-methyltransferase activity 
thiopurine S-methyltransferase activity  
trans-aconitate 2-methyltransferase activity 
trans-aconitate 3-methyltransferase activity 
tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity 
tRNA (adenine) methyltransferase activity +   
tRNA (cytosine) methyltransferase activity +   
tRNA (guanine) methyltransferase activity +   
tryptophan 2-C-methyltransferase activity 
tyramine N-methyltransferase activity 
uroporphyrin-III C-methyltransferase activity 
vitexin 2''-O-rhamnoside 7-O-methyltransferase activity 

Synonyms
Exact Synonyms: S-adenosyl-L-methionine:protein-C-terminal-S-farnesyl-L-cysteine O-methyltransferase activity ;   S-farnesylcysteine methyltransferase activity ;   farnesyl cysteine C-terminal methyltransferase activity ;   farnesyl-protein carboxymethyltransferase activity ;   farnesylated protein C-terminal O-methyltransferase activity ;   isoprenylated protein methyltransferase activity ;   prenylated protein carboxyl methyltransferase activity ;   prenylated protein methyltransferase activity ;   prenylcysteine carboxylmethyltransferase activity ;   prenylcysteine carboxymethyltransferase activity ;   prenylcysteine methyltransferase activity ;   protein C-terminal farnesylcysteine O-methyltransferase activity ;   protein S-farnesylcysteine C-terminal methyltransferase activity ;   protein-S-isoprenylcysteine O-methyltransferase activity
Related Synonyms: isoprenylcysteine carboxylmethyltransferase activity ;   prenylcysteine carboxyl methyltransferase activity
Alternate IDs: GO:0018225
Xrefs: EC:2.1.1.100 ;   KEGG_REACTION:R04496 ;   MetaCyc:2.1.1.100-RXN ;   reactome:R-HSA-6788650 "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins"
Definition Sources: EC:2.1.1.100

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.