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Ontology Browser

Term:
Parent Terms Term With Siblings Child Terms
CAAX-protein geranylgeranyltransferase activity  
Rab geranylgeranyltransferase activity  
Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family.

Synonyms
Exact Synonyms: GGTase-II activity ;   GGTaseII activity ;   Rab-protein geranylgeranyltransferase activity ;   RabGGTase activity ;   geranylgeranyl-diphosphate,geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity ;   protein geranylgeranyltransferase type II activity
Related Synonyms: type II protein geranyl-geranyltransferase activity
Xrefs: EC:2.5.1.60 ;   MetaCyc:RXN-19995 ;   MetaCyc:RXN-19996 ;   MetaCyc:RXN-19997
Definition Sources: EC:2.5.1.60, GOC:mah, PMID:8621375

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