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Ontology Browser

Term:
ribonuclease III activity (GO:0004525)
Annotations: Rat: (4) Mouse: (4) Human: (4) Chinchilla: (4) Bonobo: (4) Dog: (4) Squirrel: (2) Pig: (4)
Parent Terms Term With Siblings Child Terms
3'-tRNA processing endoribonuclease activity  
apurinic/apyrimidinic endoribonuclease activity 
endoribonuclease activity, cleaving miRNA-paired mRNA  
endoribonuclease activity, cleaving siRNA-paired mRNA  
phosphodiesterase decapping endonuclease activity  
ribonuclease [poly-(U)-specific] activity 
ribonuclease III activity +   
Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt.
ribonuclease IV activity 
ribonuclease IX activity 
ribonuclease M5 activity 
ribonuclease P activity  
ribonuclease P4 activity 
RNA lariat debranching enzyme activity  
RNA-DNA hybrid ribonuclease activity  

Synonyms
Exact Synonyms: RNase III activity ;   ribonuclease 3 activity
Narrow Synonyms: pre-mRNA 3'-end processing endonuclease
Xrefs: EC:3.1.26.3 ;   MetaCyc:3.1.26.3-RXN ;   reactome:R-HSA-203862 "Dicer cleaves pre-miRNA to yield duplex miRNA" ;   reactome:R-HSA-203893 "Microprocessor complex cleaves pri-miRNA to pre-miRNA" ;   reactome:R-HSA-426464 "Dicer cleaves double-stranded RNA to yield double-stranded siRNA"
Definition Sources: PMID:11157775, PMID:15242644

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.