| Parent Terms |
Term With Siblings |
Child Terms |
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aspartic-type endopeptidase activity +
cysteine-type endopeptidase activity +
glutamic-type endopeptidase activity
metalloendopeptidase activity +
peptidoglycan endopeptidase activity +
serine-type endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
serine-type exopeptidase activity +
threonine-type endopeptidase activity
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| Synonyms |
| Related Synonyms: |
blood coagulation factor activity
;
serine elastase activity
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| Xrefs: |
EC:3.4.21
;
Reactome:R-HSA-114697 "Activated thrombin (factor IIa) cleaves PAR3,4, activating them"
;
Reactome:R-HSA-5210912 "Furin cleaves ANTXR2-bound pagA to yield pagA(197-794)"
;
Reactome:R-HSA-5210935 "Furin cleaves ANTXR1-bound pagA to yield pagA(197-794)"
;
Reactome:R-HSA-8874145 "MBTPS1 (S1P) cleaves ATF6B (ATF6-beta)"
;
Reactome:R-HSA-9653249 "Cleavage of factor XII variant by activated thrombin"
;
Reactome:R-HSA-9655046 "Cleavage of FXII variant by KLKB1"
;
Reactome:R-HSA-9662786 "FURIN cleaves ADAM17"
;
Reactome:R-HSA-9666383 "F8 variant is not cleaved by thrombin"
;
Reactome:R-HSA-9668253 "Hyperactivation of factor X by FVIIIa:FIXa R384L"
;
Reactome:R-HSA-9668365 "FVIIIa variant:FIXa does not convert FX to the active FXa"
;
Reactome:R-HSA-9670874 "FIXa variant:FVIIIa does not convert FX to the active FXa"
;
Reactome:R-HSA-9673223 "FIX(29-461) variant is not activated (factor XIa catalyst)"
;
Reactome:R-HSA-9686710 "Cleavage of S protein into S1:S2"
;
Reactome:R-HSA-9686731 "TMPRSS2 Mediated SARS-CoV-1 Spike Protein Cleavage and Endocytosis"
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Reactome:R-HSA-9694287 "Cleavage of S protein into S1:S2"
;
Reactome:R-HSA-9694661 "TMPRSS2 Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis"
;
Reactome:R-HSA-9698988 "Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid"
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Reactome:R-HSA-9699007 "FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis"
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Reactome:R-HSA-9708859 "Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it"
;
Reactome:R-HSA-9710106 "ELANE cleaves GSDMD"
;
Reactome:R-HSA-9710263 "GZMB cleaves GSDME"
;
Reactome:R-HSA-9769949 "FURIN Mediated SARS-CoV-2 Spike Protein Cleavage"
;
Reactome:R-HSA-9770187 "S2 Cleavage by TMPRSS2 Exposes S2' Initiating Cell-Cell Fusion"
;
Reactome:R-HSA-9829030 "Nascent F signal peptide is cleaved at ER membrane"
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Reactome:R-HSA-9829200 "F0 is cleaved, releasing F1, F2, F(110-136)"
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Reactome:R-HSA-9830805 "Nascent sG localizes to ER lumen, gets glycosylated"
;
Reactome:R-HSA-9830882 "Nascent G signal peptide is cleaved at ER membrane"
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reactome:R-HSA-1181152 "Cleavage of NODAL proprotein"
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reactome:R-HSA-139893 "Granzyme-B activates BID by cleavage"
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reactome:R-HSA-140599 "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides"
;
reactome:R-HSA-140664 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst)"
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reactome:R-HSA-140696 "factor V -> factor Va + factor V activation peptide"
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reactome:R-HSA-140700 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst)"
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reactome:R-HSA-140736 "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst)"
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reactome:R-HSA-140769 "factor VII -> factor VIIa"
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reactome:R-HSA-140777 "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst)"
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reactome:R-HSA-140823 "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst)"
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reactome:R-HSA-140840 "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B"
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reactome:R-HSA-140870 "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin"
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reactome:R-HSA-141026 "Activated protein C cleaves factor Va to factor Vi intermediate form"
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reactome:R-HSA-141040 "Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C"
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reactome:R-HSA-1454843 "E-cadherin degradation by MMP3, MMP7 and plasmin."
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reactome:R-HSA-1474197 "Collagen type II degradation by MMP1,3,8,13,PRSS2"
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reactome:R-HSA-1566962 "Elastin degradation by elastin-degrading extracellular proteinases"
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reactome:R-HSA-1566979 "Laminin-332 degradation by laminin-322 degrading extracellular proteinases"
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reactome:R-HSA-1566981 "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS"
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reactome:R-HSA-158137 "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer"
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reactome:R-HSA-158164 "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst)"
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reactome:R-HSA-158300 "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst)"
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reactome:R-HSA-158311 "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin"
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reactome:R-HSA-158313 "factor XII -> factor XIIa"
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reactome:R-HSA-158333 "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst)"
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reactome:R-HSA-158419 "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst)"
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reactome:R-HSA-158744 "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin"
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reactome:R-HSA-158747 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain)"
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reactome:R-HSA-158750 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin"
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reactome:R-HSA-158766 "fibrin multimer, crosslinked -> fibrin digestion products (plasmin)"
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reactome:R-HSA-158925 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst)"
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reactome:R-HSA-158942 "urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR"
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reactome:R-HSA-158982 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst)"
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reactome:R-HSA-1592270 "NID1 degradation by MMP1, 9, 12, ELANE"
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reactome:R-HSA-1592278 "Autocatalytic activation of proMMP2"
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reactome:R-HSA-1592297 "Full activation of MMP1"
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reactome:R-HSA-1592314 "HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12)"
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reactome:R-HSA-1592316 "Initial activation of proMMP1"
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reactome:R-HSA-1592362 "Activation of proMMP7 by MMP3"
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reactome:R-HSA-1592371 "Initial activation of proMMP3"
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reactome:R-HSA-1592398 "Activation of proMMP8"
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reactome:R-HSA-1592436 "Initial activation of proMMP9 by MMPs"
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reactome:R-HSA-159728 "Furin cleaves pro-prothrombin to prothrombin"
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reactome:R-HSA-159733 "Furin cleaves pro-factor X to factor X"
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reactome:R-HSA-159771 "Furin cleaves pro-protein C to protein C"
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reactome:R-HSA-159773 "Furin cleaves pro-protein S to protein S"
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reactome:R-HSA-159796 "Furin cleaves pro-factor IX to factor IX"
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reactome:R-HSA-159868 "Furin cleaves pro-factor VII to factor VII"
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reactome:R-HSA-1602458 "Activation of proMMP10"
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reactome:R-HSA-1602466 "Activation of MT-MMPs by FURIN"
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reactome:R-HSA-1602473 "Autocatalytic activation of MMP1"
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reactome:R-HSA-1602484 "Activation of proMMP11 by FURIN"
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reactome:R-HSA-1602488 "Initial activation of proMMP13 by plasmin and trypsin"
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reactome:R-HSA-1604359 "Initial activation of proMMP2 by MMP1, 7"
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reactome:R-HSA-1604360 "Initial activation of proMMP2 by MMP14"
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reactome:R-HSA-1604368 "Autocatalytic activation of bound proMMP2"
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reactome:R-HSA-1604690 "Activation of MMP9 intermediate form by MMPs"
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reactome:R-HSA-1604712 "Initial activation of proMMP7 by trypsin"
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reactome:R-HSA-1604722 "Activation of proMMP9 by proteases"
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reactome:R-HSA-1604731 "Autocatalytic activation of MMP3"
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reactome:R-HSA-1604732 "Autocatalytic activation of proMMP13"
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reactome:R-HSA-1604741 "Initial activation of proMMP13 by MMP14 (MT1-MMP)"
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reactome:R-HSA-1604752 "Initial activation of proMMP13 by MMP3"
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reactome:R-HSA-1604763 "Autocatalytic activation of MMP7"
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reactome:R-HSA-163798 "Furin cleaves pro-protein Z to protein Z"
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reactome:R-HSA-163843 "Furin cleaves pro-GAS6 to GAS6"
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reactome:R-HSA-1655842 "S1P hydrolyzes SREBP1A,1C,2"
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reactome:R-HSA-166753 "Conversion of C4 into C4a and C4b"
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reactome:R-HSA-166792 "Conversion of C2 into C2a and C2b"
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reactome:R-HSA-166817 "Cleavage of C3 by C3 convertases"
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reactome:R-HSA-170844 "Latent TGF-beta-1 is cleaved by furin"
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reactome:R-HSA-171288 "Cleavage of the viral Env gp160 precursor polyprotein"
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reactome:R-HSA-173626 "Activation of C1r"
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reactome:R-HSA-173631 "Activation of C1s"
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reactome:R-HSA-173680 "Activation of C5"
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reactome:R-HSA-173745 "Factor D cleaves C3(H2O)-bound Factor B"
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reactome:R-HSA-174551 "Formation of alternative pathway C5 convertase"
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reactome:R-HSA-1799329 "Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein"
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reactome:R-HSA-183122 "Factor D cleaves C3b-bound Factor B"
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reactome:R-HSA-183130 "C3(H2O):Factor Bb cleaves C3 to C3b and C3a"
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reactome:R-HSA-186785 "PDGF-AA clevage by Furin"
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reactome:R-HSA-187020 "Part of pro-beta-NGF is processed to mature beta-NGF"
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reactome:R-HSA-1912369 "NOTCH precursor cleaved to form mature NOTCH"
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reactome:R-HSA-1912372 "Fringe-modified Pre-NOTCH is cleaved by FURIN"
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reactome:R-HSA-2022411 "Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)"
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reactome:R-HSA-2129357 "Fibrillin C-terminal processing"
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reactome:R-HSA-2168923 "Collagen type XVIII endostatin release"
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reactome:R-HSA-2168960 "Collagen type XVII ectodomain shedding"
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reactome:R-HSA-2172405 "Collagen type XXIII ectodomain shedding"
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reactome:R-HSA-2214330 "Cleavage of collagen VII NC2 region by BMP1"
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reactome:R-HSA-2471621 "Endostatin degradation by cathepsins"
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reactome:R-HSA-2471842 "Collagen type XXV ectomain shedding"
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reactome:R-HSA-2482180 "Collagen type VIII degradation by ELANE"
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reactome:R-HSA-2514772 "Fibrillin-1 degradation by MMP3, CTSK, CTSL2"
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reactome:R-HSA-2514823 "Fibrillin-1 degradation by ELANE"
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reactome:R-HSA-2534160 "HSPG2 (perlecan) degradation by MMP13, CTSS"
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reactome:R-HSA-2534206 "E-cadherin degradation by PS1:NCSTN (Gamma-secretase)"
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reactome:R-HSA-2534260 "E-cadherin degradation by caspase-3 and calpain-1"
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reactome:R-HSA-265301 "Corticotropin cleavage from POMC"
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reactome:R-HSA-3266557 "Factor I cleaves iC3b"
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reactome:R-HSA-3785684 "Fibronectin degradation by CTSG"
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reactome:R-HSA-3788061 "Fibronectin degradation by ADAM8"
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reactome:R-HSA-381135 "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha)"
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reactome:R-HSA-381446 "Thrombin proteolyzes IGF:IGFBP3:ALS"
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reactome:R-HSA-381461 "Plasmin proteolyzes IGF:IGFBP-3:ALS"
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reactome:R-HSA-381466 "Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS"
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reactome:R-HSA-3814820 "HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1"
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reactome:R-HSA-381500 "Cathepsin G proteolyzes IGF:IGFBP3:ALS"
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reactome:R-HSA-381798 "PCSK1 hydrolyzes Proglucagon to Glucagon-like Peptide-1"
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reactome:R-HSA-382061 "Extracellular processing of novel PDGFs"
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reactome:R-HSA-3928657 "MMP2,9 cleave EPHB"
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reactome:R-HSA-400459 "Signal peptidase hydrolyzes preproGLP-1 to proGLP-1"
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reactome:R-HSA-400492 "PCSK1 hydrolyzes proGIP to GIP"
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reactome:R-HSA-400496 "Signal peptidase hydrolyzes preproGIP to proGIP"
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reactome:R-HSA-422021 "PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin"
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reactome:R-HSA-422051 "Cleavage of the signal peptide of Preproghrelin"
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reactome:R-HSA-5578783 "CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151)"
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reactome:R-HSA-5591040 "Activated protein C cleaves Factor Va intermediate form for Factor Va"
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reactome:R-HSA-5607002 "Activated protein C cleaves factor VIIIa"
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reactome:R-HSA-5691512 "APEH hydrolyses NAc-Ser-protein"
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reactome:R-HSA-6800198 "HPN heterodimer cleaves pro-MST1 to form MST1 dimer"
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reactome:R-HSA-6800200 "HPN heterodimer cleaves pro-HGF to form HGF dimer"
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reactome:R-HSA-6800299 "HGFAC cleaves pro-HGF to form HGF dimer"
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reactome:R-HSA-6801687 "PRTN3 cleaves CAMP(31-170) to generate CAMP(134-170)"
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reactome:R-HSA-6807224 "Furin cleaves pro-BGLAP to BGLAP"
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reactome:R-HSA-8849826 "ST14 hydrolyzes and activates KLK5"
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reactome:R-HSA-8849857 "KLK5 cleaves and activates CELA2"
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reactome:R-HSA-8850831 "KLK5 cleaves and activates KLK8"
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reactome:R-HSA-8852716 "Thrombin, ELANE cleave C5"
;
reactome:R-HSA-8855825 "HTRA1 hydrolyzes ACAN (Aggrecan)"
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reactome:R-HSA-8865275 "PDGF-BB clevage by Furin"
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reactome:R-HSA-8865276 "PDGF-AB clevage by Furin"
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reactome:R-HSA-8874186 "MBTPS1 (S1P) cleaves CREB3L4"
;
reactome:R-HSA-8874204 "MBTPS1 (S1P) cleaves CREB3"
;
reactome:R-HSA-8874205 "MBTPS1 (S1P) cleaves CREB3L2"
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reactome:R-HSA-8874206 "MBTPS1 (S1P) cleaves CREB3L3"
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reactome:R-HSA-8874212 "MBTPS1 (S1P) cleaves CREB3L1"
;
reactome:R-HSA-9023178 "PCSK2 cleaves Insulin(57-110) to yield Insulin(90-110) and C-peptide (Insulin(57-89))"
;
reactome:R-HSA-9023196 "PCSK1 cleaves proinsulin to yield Insulin(25-56) and Insulin(57-110)"
;
reactome:R-HSA-9023626 "DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP)"
;
reactome:R-HSA-9023627 "DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP)"
;
reactome:R-HSA-9023632 "DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)"
;
reactome:R-HSA-9023633 "DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)"
;
reactome:R-HSA-9033490 "TYSND1 cleaves PHYH"
;
reactome:R-HSA-9033506 "TYSND1 cleaves AGPS"
;
reactome:R-HSA-9033515 "TYSND1 cleaves ACOX1"
;
reactome:R-HSA-9033520 "TYSND1 cleaves TYSND1"
;
reactome:R-HSA-9033524 "TYSND1 cleaves SCP2"
;
reactome:R-HSA-9033529 "TYSND1 cleaves ACAA1"
;
reactome:R-HSA-9033530 "TYSND1 cleaves HSD17B4"
;
reactome:R-HSA-976743 "Factor I inactivates plasma Factor H-bound C3b"
;
reactome:R-HSA-977371 "Factor I inactivates Factor H-boundC3b"
;
reactome:R-HSA-977615 "Factor I inactivates MCP/CR1-bound C4b/C3b" |
| Definition Sources: |
GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE |
|
