| Parent Terms |
Term With Siblings |
Child Terms |
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aspartic-type endopeptidase activity +
cysteine-type endopeptidase activity +
glutamic-type endopeptidase activity
metal-dependent deNEDDylase activity
metal-dependent deubiquitinase activity
metalloendopeptidase activity + Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
metalloexopeptidase activity +
peptidoglycan endopeptidase activity +
serine-type endopeptidase activity
threonine-type endopeptidase activity
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| Synonyms |
| Narrow Synonyms: |
metalloendoprotease activity
;
metalloendoproteinase activity
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| Xrefs: |
EC:3.4.24
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Reactome:R-HSA-181567 "botC LC cleaves target cell STX1"
;
Reactome:R-HSA-194793 "botC LC cleaves target cell SNAP25"
;
Reactome:R-HSA-194796 "botB LC cleaves target cell VAMP2"
;
Reactome:R-HSA-194800 "botE LC cleaves target cell SNAP25"
;
Reactome:R-HSA-194808 "botF LC cleaves target cell VAMP1"
;
Reactome:R-HSA-194809 "botD LC cleaves target cell VAMP1"
;
Reactome:R-HSA-194818 "botA LC cleaves target cell SNAP25"
;
Reactome:R-HSA-2533950 "Fibronectin degradation by MMP14"
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Reactome:R-HSA-3371385 "TNF- is cleaved by ADAM17 (TACE)"
;
Reactome:R-HSA-5228578 "tetX LC cleaves target cell VAMP2"
;
Reactome:R-HSA-5250606 "botD LC cleaves target cell VAMP2"
;
Reactome:R-HSA-5250892 "botF LC cleaves target cell VAMP2"
;
Reactome:R-HSA-5250962 "botG LC cleaves target cell VAMP2"
;
Reactome:R-HSA-5250978 "botG LC cleaves target cell VAMP1"
;
Reactome:R-HSA-8874122 "MBTPS2 (S2P) cleaves ATF6B (ATF6-beta)"
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Reactome:R-HSA-9624272 "MMPs cleave HB-EGF"
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Reactome:R-HSA-9822532 "ADAMTS13 cleaves VWF multimer"
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Reactome:R-HSA-9824402 "ADAMTS13 variant does not cleave VWF multimer"
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Reactome:R-HSA-9840408 "OMA1 cleaves DELE1"
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Reactome:R-HSA-9840532 "OMA1 self-cleaves"
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Reactome:R-HSA-9840564 "OMA1 hydrolyzes YME1L1"
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Reactome:R-HSA-9844241 "ADAMTS13 cleaves VWF variant multimer"
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reactome:R-HSA-1168777 "Metalloprotease cleavage of GHR"
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reactome:R-HSA-1251992 "Cleavage of P-ERBB4jmA isoforms by ADAM17"
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reactome:R-HSA-1299476 "MPP cleaves targeting peptide (presequence) of inner membrane precursors"
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reactome:R-HSA-1299478 "MPP cleaves targeting peptide (presequence) of matrix precursors"
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reactome:R-HSA-1454757 "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13"
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reactome:R-HSA-1454822 "Collagen type I degradation by MMP1,2,8,13, PRSS2"
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reactome:R-HSA-1458433 "Collagen type I degradation by MMP14"
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reactome:R-HSA-1474196 "Collagen type II degradation by MMP14"
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reactome:R-HSA-1474210 "Collagen type III degradation by MMP14"
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reactome:R-HSA-1474213 "Collagen type III degradation by MMP1,8,9,13"
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reactome:R-HSA-1564112 "Collagen type VI degradation by MMP2,9,11"
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reactome:R-HSA-1564117 "Collagen type XIV degradation by MMP9,13"
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reactome:R-HSA-1564120 "Collagen type VII degradation by MMP1,2,3"
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reactome:R-HSA-1564142 "Collagen type IV degradation by MMP2,3,4,9,10,12"
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reactome:R-HSA-1564143 "Collagen type X degradation by MMP1,2"
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reactome:R-HSA-1564164 "Collagen type V degradation by MMP2,9,10"
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reactome:R-HSA-1564169 "Collagen type VIII degradation by MMP1"
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reactome:R-HSA-1564179 "Collagen type XI degradation by MMP1,2,3,9"
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reactome:R-HSA-1564184 "Collagen type IX degradation by MMP3,13"
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reactome:R-HSA-1592310 "Aggrecan degradation by ADAMTSs"
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reactome:R-HSA-1655851 "S2P hydrolyzes SREBP1A,1C,2"
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reactome:R-HSA-177946 "Pro-EGF is cleaved to form mature EGF"
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reactome:R-HSA-2002428 "Removal of fibrillar collagen N-propeptides"
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reactome:R-HSA-2002440 "Removal of fibrillar collagen C-propeptides"
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reactome:R-HSA-2022141 "Prolysyl oxidase activation"
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reactome:R-HSA-2168046 "Collagen type XII degradation by MMP12"
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reactome:R-HSA-2168982 "Collagen type XVI degradation by MMP9"
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reactome:R-HSA-2179402 "Active MMP3 can cleave pro-HBEGF to form active HBEGF"
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reactome:R-HSA-2473584 "Collagen type III degradation by MMP15"
;
reactome:R-HSA-2473594 "Collagen type II degradation by MMP15"
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reactome:R-HSA-2473596 "Collagen type I degradation by MMP15"
;
reactome:R-HSA-2484882 "Collagen type X degradation by MMP3, 13"
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reactome:R-HSA-2485111 "Collagen type III degradation by MMP10"
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reactome:R-HSA-2485148 "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13"
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reactome:R-HSA-2514790 "Elastin degradation by MMP14"
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reactome:R-HSA-2514831 "Fibrillin-1 degradation by MMP14"
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reactome:R-HSA-2533874 "Laminin-511 degradation by MMP14"
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reactome:R-HSA-2533944 "Fibronectin degradation by MMP10"
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reactome:R-HSA-2533965 "NID1 degradation by MMP14, MMP15"
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reactome:R-HSA-2533970 "NID1 degradation by MMP3, 7"
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reactome:R-HSA-2534240 "HSPG2 (perlecan) degradation by MMP14, MMP15"
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reactome:R-HSA-2534248 "DCN (decorin) degradation by MMP2, MMP3, MMP7"
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reactome:R-HSA-2537499 "Gelatin degradation by MMP19"
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reactome:R-HSA-264758 "BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1"
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reactome:R-HSA-3788075 "Brevican degradation by ADAMTS4, ADAMTS5"
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reactome:R-HSA-3791149 "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19"
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reactome:R-HSA-3791155 "Laminin-322 degradation by MMP14"
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reactome:R-HSA-3791295 "Aggrecan degradation by MMP1,2,3,7,9,12,13"
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reactome:R-HSA-3791319 "NID1 degradation by MMP19"
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reactome:R-HSA-381435 "Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS"
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reactome:R-HSA-381518 "PAAP-A proteolyzes IGF:IGFBP4"
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reactome:R-HSA-381537 "PAPP-A2 proteolyzes IGF:IGFBP5:ALS"
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reactome:R-HSA-3827958 "E-cadherin degradation by MMP9, KLK7"
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reactome:R-HSA-3828025 "DCN (decorin) degradation by MMP14"
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reactome:R-HSA-4086205 "OPN (osteopontin) degradation by MMP3, MMP7"
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reactome:R-HSA-420818 "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)"
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reactome:R-HSA-4224014 "E-cadherin degradation by ADAM10, ADAM15"
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reactome:R-HSA-5333671 "CLCAs self cleave"
;
reactome:R-HSA-5362793 "Hh-Np is cleaved by ADAM17 to promote ligand shedding"
;
reactome:R-HSA-5694082 "XK:KEL:Zn2+ cleaves EDN3"
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reactome:R-HSA-6784620 "MBTPS1,2 cleaves CREB3L3 to CREB3L3(1-?) and CREB3L3(?-461)"
;
reactome:R-HSA-8867344 "OMA1 hydrolyses OPA1"
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reactome:R-HSA-8874187 "MBTPS2 (S2P) cleaves CREB3L2"
;
reactome:R-HSA-8874192 "MBTPS2 (S2P) cleaves CREB3"
;
reactome:R-HSA-8874194 "MBTPS2 (S2P) cleaves CREB3L1"
;
reactome:R-HSA-8874195 "MBTPS2 (S2P) cleaves CREB3L4"
;
reactome:R-HSA-8874201 "MBTPS2 (S2P) cleaves CREB3L3"
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reactome:R-HSA-8876868 "ECE1 cleaves EDN1(53-90)"
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reactome:R-HSA-8877620 "ECE2 cleaves EDN1(53-90)"
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reactome:R-HSA-8940554 "MMP2 cleaves OPTC"
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reactome:R-HSA-8940561 "MMP7 cleaves OPTC"
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reactome:R-HSA-8940641 "THOP1 cleaves oligopeptide fragment (8-16aa)"
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reactome:R-HSA-8940959 "Neurolysin degrades neurotensin"
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reactome:R-HSA-8942302 "MMP13 cleaves OPTC"
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reactome:R-HSA-8943959 "MMP2, MMP9 cleave SCUBE3"
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reactome:R-HSA-8949649 "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)"
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reactome:R-HSA-8949659 "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU"
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reactome:R-HSA-8949668 "YME1L1 proteolyzes unassembled proSMDT1" |
| Definition Sources: |
GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE |
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