Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

Ontology Browser

Term:
aldo-keto reductase (NADP) activity (GO:0004033)
Annotations: Rat: (33) Mouse: (36) Human: (28) Chinchilla: (10) Bonobo: (12) Dog: (20) Squirrel: (10) Pig: (19)
Parent Terms Term With Siblings Child Terms
(+)-borneol dehydrogenase activity 
(+)-neomenthol dehydrogenase activity 
(+)-sabinol dehydrogenase activity 
(+)-trans-carveol dehydrogenase activity 
(-)-borneol dehydrogenase activity 
(-)-lactol dehydrogenase activity 
(-)-menthol dehydrogenase activity 
(-)-secoisolariciresinol dehydrogenase activity 
(R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity 
(R)-2-hydroxy-fatty acid dehydrogenase activity 
(R)-2-hydroxyacid dehydrogenase activity 
(R)-2-hydroxyisocaproate dehydrogenase activity 
(R)-3-hydroxyacid-ester dehydrogenase activity 
(R)-4-hydroxyphenyllactate dehydrogenase activity 
(R)-aminopropanol dehydrogenase activity 
(R)-lactaldehyde dehydrogenase activity 
(R)-sulfopropanediol 2-dehydrogenase activity 
(R,R)-butanediol dehydrogenase activity  
(S)-2-hydroxy-fatty acid dehydrogenase activity 
(S)-3-hydroxyacid-ester dehydrogenase activity 
(S)-carnitine 3-dehydrogenase activity 
(S)-usnate reductase activity 
(S,S)-butanediol dehydrogenase activity 
1,3-propanediol dehydrogenase activity 
1,5-anhydro-D-fructose reductase (1,5-anhydro-D-mannitol-forming) activity 
1,5-anhydro-D-fructose reductase activity  
1-acyl dihydroxyacetone phosphate reductase activity 
1-deoxy-D-xylulose-5-phosphate reductoisomerase activity 
10-hydroxygeranial oxidoreductase activity 
10-hydroxygeraniol oxidoreductase activity 
10-oxogeraniol oxidoreductase activity 
11-cis-retinol dehydrogenase activity 
11-deoxycorticosterone reductase activity 
13-lipoxin reductase activity  
13-prostaglandin reductase activity  
15-hydroxyicosatetraenoate dehydrogenase activity 
15-hydroxyprostaglandin dehydrogenase (NAD+) activity  
15-hydroxyprostaglandin dehydrogenase (NADP+) activity  
15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity  
15-hydroxyprostaglandin-I dehydrogenase (NADP+) activity 
16-hydroxypalmitate dehydrogenase activity  
2,5-didehydrogluconate reductase activity 
2-(R)-hydroxypropyl-CoM dehydrogenase activity 
2-(S)-hydroxypropyl-CoM dehydrogenase activity 
2-alkyn-1-ol dehydrogenase activity 
2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase activity 
2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase activity 
2-dehydropantoate 2-reductase activity 
2-dehydropantolactone reductase activity +  
2-deoxy-D-gluconate 3-dehydrogenase activity 
2-hydroxy-3-oxopropionate reductase activity 
2-hydroxymethylglutarate dehydrogenase activity 
2-hydroxytetrahydrofuran dehydrogenase activity 
2-oxoadipate reductase activity 
3''-deamino-3''-oxonicotianamine reductase activity 
3-(imidazol-5-yl)lactate dehydrogenase activity 
3-alpha-hydroxy-5-beta-androstane-17-one 3-alpha-dehydrogenase activity 
3-alpha-hydroxycholanate dehydrogenase activity 
3-alpha-hydroxyglycyrrhetinate dehydrogenase activity 
3-beta-hydroxysteroid dehydrogenase/C4-decarboxylase activity 
3-dehydro-L-gulonate 2-dehydrogenase activity 
3-dehydrosphinganine reductase activity  
3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity  
3-hydroxyacyl-CoA dehydrogenase activity +   
3-hydroxybenzyl-alcohol dehydrogenase activity 
3-hydroxybutyrate dehydrogenase activity  
3-hydroxybutyryl-CoA dehydrogenase activity 
3-hydroxyisobutyrate dehydrogenase activity  
3-hydroxymenthone dehydrogenase activity 
3-hydroxypimeloyl-CoA dehydrogenase activity 
3-hydroxypropionate dehydrogenase (NAD+) activity 
3-hydroxypropionate dehydrogenase (NADP+) activity 
3-isopropylmalate dehydrogenase activity 
3-keto sterol reductase activity  
3-ketodihydrosphinganine (C18) reductase activity 
3-ketodihydrosphinganine (C20) reductase activity 
3-ketoglucose-reductase activity 
3-oxo-arachidoyl-CoA reductase activity  
3-oxo-behenoyl-CoA reductase activity  
3-oxo-cerotoyl-CoA reductase activity  
3-oxo-cis-Delta9-hexadecenoyl-[acp] reductase activity 
3-oxo-glutaryl-[acp] methyl ester reductase activity  
3-oxo-lignoceroyl-CoA reductase activity  
3-oxo-pimeloyl-[acp] methyl ester reductase activity  
3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity  
3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity  
3-sulfolactaldehyde reductase activity 
3beta-hydroxy-5alpha-steroid dehydrogenase activity 
3beta-hydroxy-5beta-steroid dehydrogenase activity 
3beta-hydroxysteroid dehydrogenase activity 
4-(hydroxymethyl)benzenesulfonate dehydrogenase activity 
4-carboxy-2-hydroxymuconate semialdehyde hemiacetal dehydrogenase activity 
4-hydroxy-L-isoleucine dehydrogenase activity 
4-hydroxybutyrate dehydrogenase activity 
4-hydroxycyclohexanecarboxylate dehydrogenase activity 
4-hydroxythreonine-4-phosphate dehydrogenase activity 
4-oxoproline reductase activity 
4-phosphoerythronate dehydrogenase activity 
4alpha-carboxy,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-cholest-24-en-3beta-ol dehydrogenase/C4-decarboxylase activity 
4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-oxidoreductase (decarboxylating) activity  
4alpha-carboxy-5alpha-cholesta-7,24-dien-3beta-ol dehydrogenase/C4-decarboxylase activity 
4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol:NAD(P)+ 3-dehydrogenase (decarboxylating) activity  
4alpha-carboxy-stigmasta-7,24(241)-dien-3beta-ol dehydrogenase/C4-decarboxylase activity 
5'-hydroxyaverantin dehydrogenase activity 
5(S)-hydroxyeicosatetraenoic acid dehydrogenase activity 
5-amino-6-(5-phosphoribosylamino)uracil reductase activity 
5-exo-hydroxycamphor dehydrogenase activity 
5-hydroxyvalerate dehydrogenase activity 
6-endo-hydroxycineole dehydrogenase activity 
6-hydroxyhexanoate dehydrogenase activity 
6-pyruvoyltetrahydropterin 2'-reductase activity 
8-hydroxygeraniol dehydrogenase activity 
8-oxocoformycin reductase activity 
acetoacetyl-CoA reductase activity  
acetoin dehydrogenase activity +  
acylglycerone-phosphate reductase activity  
alcohol dehydrogenase [NAD(P)+] activity +   
aldo-keto reductase (NADP) activity +   
Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+.
aldose 1-dehydrogenase activity 
aldose-6-phosphate reductase (NADPH) activity 
allyl-alcohol dehydrogenase activity  
alpha-ketoglutarate reductase activity (NADH-dependent) 
apiose 1-reductase activity 
aryl-alcohol dehydrogenase (NAD+) activity 
aryl-alcohol dehydrogenase (NADP+) activity 
avenastenone reductase activity 
benzil reductase [(S)-benzoin-forming] activity 
benzyl-2-methyl-hydroxybutyrate dehydrogenase activity 
beta-keto ester reductase activity 
C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity  
carbonyl reductase (NADPH) activity  
carnitine 3-dehydrogenase activity 
carveol dehydrogenase activity 
chlordecone reductase activity  
chlorophyll(ide) b reductase activity 
cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity  
cholestanetetraol 26-dehydrogenase activity 
cholesterol dehydrogenase activity  
choline monooxygenase activity (NADP-dependent) 
cinnamyl-alcohol dehydrogenase activity 
codeinone reductase (NADPH) activity 
coniferyl-alcohol dehydrogenase activity 
cortisol dehydrogenase activity 
cycloeucalenone reductase activity 
cyclohexane-1,2-diol dehydrogenase activity 
cyclohexanol dehydrogenase activity 
cyclopentanol dehydrogenase activity 
D-arabinitol 2-dehydrogenase activity 
D-arabinitol 4-dehydrogenase activity 
D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity 
D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity 
D-arabinose 1-dehydrogenase [NAD(P)+] activity +  
D-fructuronate reductase activity 
D-galacturonate reductase activity 
D-iditol 2-dehydrogenase activity 
D-lactate dehydrogenase activity  
D-malate dehydrogenase (decarboxylating) activity 
D-pinitol dehydrogenase activity 
D-threo-aldose 1-dehydrogenase activity 
D-xylose 1-dehydrogenase (NAD) activity 
D-xylose 1-dehydrogenase (NADP+) activity  
D-xylulose reductase activity  
diethyl 2-methyl-3-oxosuccinate reductase activity 
dihydrobunolol dehydrogenase activity 
dihydrokaempferol 4-reductase activity 
diiodophenylpyruvate reductase activity  
dimethylmalate dehydrogenase activity 
dTDP-4-dehydro-6-deoxyglucose reductase activity 
dTDP-4-dehydrorhamnose reductase activity 
dTDP-4-oxo-2,6-dideoxy-D-glucose 4-ketoreductase (dTDP-D-oliose producing) activity 
dTDP-6-deoxy-L-talose 4-dehydrogenase activity 
dTDP-galactose 6-dehydrogenase activity 
dTDP-L-rhamnose synthetase activity 
epoxide dehydrogenase activity 
erythrulose reductase activity 
ethylglyoxal reductase (NADH-dependent, hydroxyacetone-forming) activity 
farnesol dehydrogenase activity  
flavanone 4-reductase activity 
fluoren-9-ol dehydrogenase activity 
fructose 5-dehydrogenase (NADP+) activity 
fructuronate reductase activity 
galactitol 2-dehydrogenase activity 
galactitol-1-phosphate 5-dehydrogenase activity 
galactose 1-dehydrogenase (NADP+) activity 
galactose 1-dehydrogenase activity 
gamma-hydroxybutyrate dehydrogenase activity (NAD(P)-dependent 
GDP-4-dehydro-6-deoxy-D-mannose reductase activity 
GDP-4-dehydro-D-rhamnose reductase activity  
GDP-6-deoxy-D-talose 4-dehydrogenase activity 
GDP-L-fucose synthase activity  
GDP-mannose 6-dehydrogenase activity 
geraniol dehydrogenase activity 
germacrene A alcohol dehydrogenase activity 
gluconate dehydrogenase activity +  
glucose-6-phosphate 3-dehydrogenase activity 
glucose-6-phosphate dehydrogenase activity  
glucuronolactone reductase activity  
glycerate dehydrogenase activity  
glycerol 2-dehydrogenase (NADP+) activity 
glycerol dehydrogenase [NAD(P)+] activity +  
glycerol-1-phosphate dehydrogenase [NAD(P)+] activity 
glycerol-3-phosphate 1-dehydrogenase [NADP+] activity 
glycerol-3-phosphate dehydrogenase [NAD(P)+] activity +   
glyoxylate reductase (NADP) activity  
glyoxylate reductase activity 
hentriaconta-3,6,9,12,19,22,25,28-octaene-16-one-15-oyl-CoA reductase activity 
hexadecanol dehydrogenase activity 
histidinol dehydrogenase activity 
homoisocitrate dehydrogenase activity 
homoserine dehydrogenase activity 
hydroxycyclohexanecarboxylate dehydrogenase activity 
hydroxymalonate dehydrogenase activity 
hydroxymethylfurfural reductase (NADH) activity 
hydroxymethylfurfural reductase (NADPH) activity 
hydroxymethylfurfural reductase activity 
hydroxymethylglutaryl-CoA reductase (NADPH) activity  
hydroxymethylglutaryl-CoA reductase activity  
hydroxyphenylpyruvate reductase activity 
hydroxypyruvate reductase activity  
hydroxyversicolorone reductase activity 
IMP dehydrogenase activity  
indanol dehydrogenase activity  
indole-3-acetaldehyde reductase (NADH) activity 
indole-3-acetaldehyde reductase (NADPH) activity 
indolelactate dehydrogenase activity 
isobutyraldehyde reductase activity 
isocitrate dehydrogenase activity +   
isocitrate-homoisocitrate dehydrogenase activity 
isopiperitenol dehydrogenase activity 
isopropanol dehydrogenase (NADP+) activity 
ketol-acid reductoisomerase activity 
L-2-hydroxycarboxylate dehydrogenase (NAD+) activity 
L-arabinitol 2-dehydrogenase activity 
L-arabinitol 4-dehydrogenase activity 
L-arabinose 1-dehydrogenase (NAD+) activity 
L-arabinose 1-dehydrogenase (NADP+) activity 
L-glucuronate reductase activity  
L-glyceraldehyde 3-phosphate reductase activity 
L-glycol dehydrogenase activity 
L-gulonate 3-dehydrogenase activity  
L-iditol 2-dehydrogenase activity  
L-idonate 5-dehydrogenase activity 
L-idonate 5-dehydrogenase activity (NAD-dependent) 
L-lactate dehydrogenase activity  
L-malate dehydrogenase activity  
L-rhamnose 1-dehydrogenase activity 
L-threo-sphinganine reductase activity 
L-threonate 3-dehydrogenase activity 
L-threonine 3-dehydrogenase activity  
L-xylose 1-dehydrogenase activity 
L-xylulose reductase (NAD+) activity  
L-xylulose reductase (NADP+) activity  
lactaldehyde reductase (NADPH) activity 
lactaldehyde reductase activity +  
long-chain-alcohol dehydrogenase activity 
malate dehydrogenase (decarboxylating) (NAD+) activity  
malate dehydrogenase (decarboxylating) (NADP+) activity  
malate dehydrogenase (NADP+) activity  
mannitol 2-dehydrogenase (NADP+) activity 
mannitol 2-dehydrogenase activity 
mannitol dehydrogenase activity 
mannitol-1-phosphate 5-dehydrogenase activity 
mannose-6-phosphate 6-reductase activity 
mannuronate reductase activity 
methanol dehydrogenase activity 
methylglyoxal reductase (NADH-dependent) activity 
methylglyoxal reductase (NADPH-dependent) activity 
methylglyoxal reductase (NADPH-dependent, acetol producing) 
methylthioalkylmalate dehydrogenase activity 
methylthiobutylmalate dehydrogenase activity 
methylthiohexylmalate dehydrogenase activity 
methylthiopentylmalate dehydrogenase activity 
methylthiopropylmalate dehydrogenase activity 
mevaldate reductase activity +   
mithramycin dehydrogenase activity 
momilactone-A synthase activity 
morphine 6-dehydrogenase activity 
N-acetylhexosamine 1-dehydrogenase activity 
N-acylmannosamine 1-dehydrogenase activity 
octanol dehydrogenase activity 
omega-hydroxydecanoate dehydrogenase activity  
oryzalexin A synthase activity 
oryzalexin B synthase activity 
oryzalexin C synthase (oryzalexin A dependent) activity 
oryzalexin C synthase (oryzalexin B dependent) activity 
oxaloglycolate reductase (decarboxylating) activity 
pantoate 4-dehydrogenase activity 
perillyl-alcohol dehydrogenase activity 
phenylacetaldehyde reductase activity 
phenylcoumaran benzylic ether reductase activity 
phosphogluconate 2-dehydrogenase activity  
phosphogluconate dehydrogenase (decarboxylating) activity  
phosphoglycerate dehydrogenase activity  
propanediol-phosphate dehydrogenase activity 
prostaglandin D2 11-ketoreductase activity  
prostaglandin H2 endoperoxidase reductase activity  
prostaglandin-E2 9-reductase activity  
prostaglandin-F synthase activity  
pterocarpin synthase activity 
pyridoxal 4-dehydrogenase activity 
quinate 3-dehydrogenase (NAD+) activity 
quinate 3-dehydrogenase (NADP+) activity 
R(+)-3,4-dihydroxyphenyllactate:NADP+ oxidoreductase activity 
retinol dehydrogenase activity  
ribitol 2-dehydrogenase activity  
ribitol-5-phosphate 2-dehydrogenase activity 
ribose 1-dehydrogenase (NADP+) activity 
S-(hydroxymethyl)glutathione dehydrogenase activity  
S-sulfolactate dehydrogenase activity 
salutaridine reductase (NADPH) activity 
scyllo-inositol dehydrogenase (NADP+) activity 
sepiapterin reductase activity  
sequoyitol dehydrogenase activity 
serine 3-dehydrogenase activity 
shikimate 3-dehydrogenase (NAD+) activity 
shikimate 3-dehydrogenase (NADP+) activity 
sinapyl alcohol dehydrogenase activity 
sorbitol-6-phosphate 2-dehydrogenase activity 
sorbose 5-dehydrogenase (NADP+) activity 
sorbose reductase activity 
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor +   
sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity  
sulcatone reductase activity 
tagaturonate reductase activity 
tartrate dehydrogenase activity 
tartronate semialdehyde reductase activity 
tetrahydroxynaphthalene reductase activity 
tropine dehydrogenase activity 
tropinone reductase activity 
UDP-3-dehydro-alpha-D-glucose dehydrogenase activity 
UDP-4-keto-rhamnose-4-keto-reductase activity 
UDP-glucose 6-dehydrogenase activity  
UDP-glucuronic acid dehydrogenase activity 
UDP-N-acetyl-alpha-D-fucosamine dehydrogenase activity 
UDP-N-acetyl-alpha-D-quinovosamine dehydrogenase activity 
UDP-N-acetyl-D-mannosamine dehydrogenase activity 
UDP-N-acetylglucosamine 6-dehydrogenase activity 
UDP-N-acetylmuramate dehydrogenase activity 
ureidoglycolate dehydrogenase activity 
uronate dehydrogenase activity 
vellosimine dehydrogenase activity 
versiconal hemiacetal acetate reductase activity 
versiconal reductase activity 
very long-chain-3-hydroxyacyl-CoA dehydrogenase activity 
vomifoliol 4'-dehydrogenase activity 
zerumbone synthase activity 

Synonyms
Exact Synonyms: NADPH-dependent aldo-keto reductase activity ;   aldo-keto reductase activity
Narrow Synonyms: alcohol dehydrogenase (NADP+) activity
Xrefs: Reactome:R-HSA-198845 "CYB5A:heme reduces Asc.- to AscH-" ;   reactome:R-HSA-192033 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one" ;   reactome:R-HSA-192036 "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol" ;   reactome:R-HSA-192067 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one" ;   reactome:R-HSA-192160 "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol" ;   reactome:R-HSA-193746 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one" ;   reactome:R-HSA-193755 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one" ;   reactome:R-HSA-193758 "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol" ;   reactome:R-HSA-193781 "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol" ;   reactome:R-HSA-193800 "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol" ;   reactome:R-HSA-193821 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one" ;   reactome:R-HSA-193824 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one" ;   reactome:R-HSA-193841 "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol" ;   reactome:R-HSA-2855252 "AKRs reduce RBP2:atRAL to RBP2:atROL" ;   reactome:R-HSA-5423637 "AKR dimers reduce AFBDHO to AFBDOH" ;   reactome:R-HSA-5692232 "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione" ;   reactome:R-HSA-9027531 "Dehydrogenase dehydrogenates 13-HDHA to 13-oxo-DHA" ;   reactome:R-HSA-9027562 "Dehydrogenase dehydrogenates 17-HDHA to 17-oxo-DHA" ;   reactome:R-HSA-9027598 "Dehydrogenase dehydrogenates 13(R)-HDPAn-3 to 13-oxo-DPAn-3" ;   reactome:R-HSA-9027600 "Dehydrogenase dehydrogenates 17-HDPAn-3 to 17-oxo-DPAn-3"
Definition Sources: GOC:ai

paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.