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Ontology Browser
Term:
methylated-DNA-[protein]-cysteine S-methyltransferase activity (GO:0003908)
Annotations: Rat: (1) Mouse: (1) Human: (1) Chinchilla: (1) Bonobo: (1) Dog: (1) Squirrel: (1) Pig: (1) Naked Mole-rat: (1) Green Monkey: (2)
Parent Terms Term With Siblings Child Terms
5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity 
betaine-homocysteine S-methyltransferase activity  
diphthine methyl ester synthase activity  
diphthine synthase activity 
histone methyltransferase activity +   
methionine synthase activity  
methylated-DNA-[protein]-cysteine S-methyltransferase activity  
Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine.
N-terminal protein N-methyltransferase activity  
protein carboxyl O-methyltransferase activity +   
protein-arginine C-methyltransferase activity 
protein-arginine N-methyltransferase activity +   
protein-cysteine methyltransferase activity  
protein-glutamine N-methyltransferase activity +   
protein-L-histidine N-pros-methyltransferase activity  
protein-L-histidine N-tele-methyltransferase activity  
protein-lysine N-methyltransferase activity +   
S-adenosylmethionine-homocysteine S-methyltransferase activity  
S-methylmethionine-homocysteine S-methyltransferase activity  
tetrahydromethanopterin S-methyltransferase activity 
thetin-homocysteine S-methyltransferase activity 
thioether S-methyltransferase activity  
thiol S-methyltransferase activity  
thiopurine S-methyltransferase activity  

Synonyms
Exact Synonyms: MGMT
Broad Synonyms: O6-alkylguanine-DNA alkyltransferase
Related Synonyms: 6-O-methylguanine-DNA methyltransferase activity ;   DNA-6-O-methylguanine:protein-L-cysteine S-methyltransferase activity ;   O-6-methylguanine-DNA-alkyltransferase activity
Xrefs: EC:2.1.1.63 ;   MetaCyc:2.1.1.63-RXN ;   RHEA:24000 ;   reactome:R-HSA-73892 "MGMT/hAGT mediated DNA Damage Reversal"
Definition Sources: EC:2.1.1.63

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