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Ontology Browser

plasma kallikrein-kinin cascade (GO:0002353)
Annotations: Rat: (3) Mouse: (3) Human: (4) Chinchilla: (3) Bonobo: (3) Dog: (3) Squirrel: (3) Pig: (3)
Parent Terms Term With Siblings Child Terms
kinin cascade +     
negative regulation of kinin cascade +  
plasma kallikrein-kinin cascade +   
A series of reactions that takes place outside the cell occurring in response to tissue damage and initiated within blood plasma by the action of activated Factor XII (Hageman Factor) on prekallikrein to convert it to plasma kallikrein, and the subsequent reaction of plasma kallikrein with high molecular weight kininogen. The ultimate product of the plasma kallikrein-kinin cascade is bradykinin, an agent known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability.
positive regulation of kinin cascade +  
regulation of kinin cascade +  
tissue kallikrein-kinin cascade +   

Definition Sources: GOC:add, ISBN:0721601871, PMID:11842287, PMID:14501145

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.