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Ontology Browser
Term:
oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity (GO:0000703)
Annotations: Rat: (2) Mouse: (2) Human: (2) Chinchilla: (1) Bonobo: (2) Dog: (2) Squirrel: (2) Pig: (2) Naked Mole-rat: (2) Green Monkey: (2)
Parent Terms Term With Siblings Child Terms
oxidized purine nucleobase lesion DNA N-glycosylase activity +   
oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity +   
Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site.

Synonyms
Exact Synonyms: oxidized pyrimidine base lesion DNA N-glycosylase activity
Broad Synonyms: DNA glycosylase/AP-lyase ;   DNA glycosylase/beta-lyase ;   bifunctional DNA glycosylase
Related Synonyms: endodeoxyribonuclease III ;   endonuclease III ;   endonuclease VIII activity ;   pyrimidine-specific oxidized base lesion DNA N-glycosylase activity
Alternate IDs: GO:0019004
Xrefs: reactome:R-HSA-110224 "Cleavage of thymine glycol by NTHL1 glycosylase" ;   reactome:R-HSA-110226 "Cleavage of cytosine glycol by NTHL1 glycosylase" ;   reactome:R-HSA-110227 "Cleavage of dihydrouracil by NTHL1 glycosylase"
Definition Sources: GOC:elh, PMID:11554296

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