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Ontology Browser
Term:
first spliceosomal transesterification activity (GO:0000384)
Annotations: Rat: (0) Mouse: (0) Human: (0) Chinchilla: (0) Bonobo: (0) Dog: (0) Squirrel: (0) Pig: (0) Naked Mole-rat: (0) Green Monkey: (0)
Parent Terms Term With Siblings Child Terms
catalytic activity, acting on a rRNA +   
catalytic activity, acting on a tRNA +   
DNA/RNA helicase activity +   
first spliceosomal transesterification activity 
Catalysis of the first transesterification reaction of spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, while it is still joined to the 3' exon.
mRNA 5'-diphosphatase activity  
mRNA 5'-triphosphate monophosphatase activity  
oxidative RNA demethylase activity +   
RNA glycosylase activity +  
RNA guanylyltransferase activity +   
RNA helicase activity +   
RNA ligase activity +   
RNA methyltransferase activity +   
RNA NAD+-cap (NAD+-forming) hydrolase activity  
RNA NAD-cap (NMN-forming) hydrolase activity  
RNA nuclease activity +   
RNA polymerase activity +   
RNA topoisomerase activity  
RNA uridylyltransferase activity  
RNA-3'-phosphate cyclase activity  
rRNA pseudouridine synthase activity +  
second spliceosomal transesterification activity  
snRNA pseudouridine synthase activity 
template-free RNA nucleotidyltransferase  
tyrosyl-RNA phosphodiesterase activity  

Synonyms
Related Synonyms: lariat formation, 5'-splice site cleavage
Definition Sources: GOC:krc, ISBN:0879695897, PMID:19239890

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