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Cancer, Alopecia, Pigment Dyscrasia, Onychodystrophy, and Keratoderma (DOID:9008147)
Annotations: Rat: (1) Mouse: (1) Human: (1) Chinchilla: (1) Bonobo: (1) Dog: (1) Squirrel: (1) Pig: (1)
Parent Terms Term With Siblings Child Terms
alopecia +     
Malformed Nails +     
acanthosis nigricans +   
adenosquamous carcinoma +   
ADULT syndrome  
Aerodigestive Tract Squamous Cell Carcinoma +   
alopecia areata +   
Alopecia Congenita Keratosis Palmoplantaris +   
Alopecia Contractures Dwarfism Mental Retardation 
alopecia universalis +   
Alopecia Universalis, Onychodystrophy, Vitiligo 
Alopecia, Epilepsy, Pyorrhea, Mental Subnormality 
Alopecia, Hypogonadism, Extrapyramidal Disorder  
alopecia, neurologic defects, and endocrinopathy syndrome  
Alopecia-Epilepsy-Oligophrenia Syndrome of Moynahan 
alopecia-mental retardation syndrome +   
Ameloonychohypohidrotic Syndrome 
anal canal squamous cell carcinoma 
anal margin squamous cell carcinoma 
anal squamous cell carcinoma +   
Androgenetic Alopecia 2 
Androgenetic Alopecia 3 
androgenic alopecia 
Anonychia Onychodystrophy 
Anonychia with Flexural Pigmentation 
atrichia with papular lesions  
autosomal dominant congenital deafness with onychodystrophy  
autosomal dominant keratosis follicularis spinulosa decalvans 
BADS syndrome 
Bart-Pumphrey syndrome  
basaloid squamous cell carcinoma +  
BASAN syndrome  
Basaran Yilmaz Syndrome  
bladder squamous cell carcinoma +   
bladder urachal squamous cell carcinoma 
Bloch-Sulzberger syndrome +   
bone squamous cell carcinoma 
Bowen's Disease  
Brachymorphism-Onychodysplasia-Dysphalangism Syndrome 
breast squamous cell carcinoma +   
Bullous Dystrophy, Hereditary Macular Type 
Cafe-au-Lait Spots +   
Cancer, Alopecia, Pigment Dyscrasia, Onychodystrophy, and Keratoderma  
CAPOK syndrome is characterized by onset of symptoms in the first year of life, with the development of progressive alopecia, hypo- and hyperpigmented macular skin lesions, palmoplantar keratoderma, and nail dystrophy. Beginning in the third decade of life, patients develop recurrent squamous cell carcinomas. Some patients may have brittle teeth resulting in tooth loss, and multinodular goiter has been observed. CAPOK can be caused by homozygous mutation in the SASH1 gene on chromosome 6q24. (OMIM)
Cartwright Nelson Fryns Syndrome 
CEDNIK syndrome  
Central Centrifugal Cicatricial Alopecia  
Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy  
cervical squamous cell carcinoma +   
Cole Disease  
colon squamous cell carcinoma 
Congenital Alopecia X-Linked 
Congenital Erythroderma with Palmoplantar Keratoderma, Hypotrichosis, and Hyper-IgE  
conjunctival pigmentation 
conjunctival squamous cell carcinoma  
cornea squamous cell carcinoma 
Corneodermatoosseous Syndrome 
Curly Hair-Acral Keratoderma-Caries Syndrome 
Curly Hair-Ankyloblepharon-Nail Dysplasia Syndrome  
Cutaneous Telangiectasia and Cancer Syndrome, Familial  
dermatopathia pigmentosa reticularis  
Diffuse Palmoplantar Keratoderma +   
DOORS syndrome  
Double Nail for Fifth Toe 
dyschromatosis symmetrica hereditaria  
dyschromatosis universalis hereditaria +   
Ectodermal Dysplasia Syndrome with Distinctive Facial Appearance and Preaxial Polydactyly of Feet 
Ectodermal Dysplasia, Alopecia, Preaxial Polydactyly 
Elejalde Disease 
endometrial squamous cell carcinoma +   
esophagus squamous cell carcinoma +   
ethmoid sinus squamous cell carcinoma 
external ear squamous cell carcinoma 
fallopian tube squamous cell carcinoma 
Familial Focal Alopecia 
Fitzsimmons-McLachlan-Gilbert syndrome 
FLOTCH Syndrome 
Focal Palmoplantar and Gingival Keratosis 
Follicular Hamartoma, Alopecia, Cystic Fibrosis 
follicular mucinosis 
frontal sinus squamous cell carcinoma 
Frontonasal Dysplasia 2  
gallbladder squamous cell carcinoma 
GAPO syndrome  
Garret Tripp Syndrome 
Gomez Lopez Hernandez Syndrome 
Gorlin Bushkell Jensen Syndrome 
Griscelli syndrome +   
Grouped Pigmentation of the Macula 
head and neck squamous cell carcinoma +   
Heimler syndrome 1  
Hereditary Koilonychia 
Heterochromia Iridis  
Hypergonadotropic Hypogonadism and Partial Alopecia 
Hyperkeratosis-Hyperpigmentation Syndrome 
Hyperpigmentation +   
Hypopigmentation +   
Hypospadias-Mental Retardation Syndrome 
hypotrichosis 7  
hypotrichosis-lymphedema-telangiectasia-renal defect syndrome  
Hypotrichosis-Osteolysis-Periodontitis-Palmoplantar Keratoderma Syndrome 
IFAP Syndrome +   
Jagell Holmgren Hofer Syndrome 
Johnson Neuroectodermal Syndrome 
Judge Misch Wright Syndrome 
keratinizing squamous cell carcinoma 
Keratoderma Palmoplantaris Transgrediens 
Keratosis Palmaris et Plantaris with Clinodactyly 
Keratosis Palmoplantaris Striata 1  
Keratosis Palmoplantaris Striata 2  
Keratosis Palmoplantaris Striata 3  
Kumar Levick Syndrome 
Kuster Majewski Hammerstein Syndrome 
lacrimal gland squamous cell carcinoma 
laryngeal squamous cell carcinoma +   
Leukomelanoderma, Infantilism, Mental Retardation, Hypodontia, Hypotrichosis 
loose anagen hair syndrome +   
lung squamous cell carcinoma +   
Macrocephaly, Alopecia, Cutis Laxa, and Scoliosis  
Macules Hereditary Congenital Hypopigmented and Hyperpigmented 
mal de Meleda  
malignant mesothelioma +   
Mammary-Digital-Nail Syndrome 
mandibulofacial dysostosis with alopecia  
maxillary sinus squamous cell carcinoma  
Microcephaly Sparse Hair Mental Retardation Seizures 
middle ear squamous cell carcinoma 
Moloney Syndrome 
mutilating palmoplantar keratoderma with periorificial keratotic plaques +   
Naegeli-Franceschetti-Jadassohn syndrome  
neonatal jaundice +   
Neurodevelopmental Disorder with Alopecia and Brain Abnormalities  
Nisch syndrome  
nonepidermolytic palmoplantar keratoderma +   
nonsyndromic congenital nail disorder +   
Oculocerebral Hypopigmentation Syndrome Type Preus 
Onychotrichodysplasia and Neutropenia 
Otoonychoperoneal Syndrome 
ovarian squamous cell carcinoma  
Palmoplantar Hyperkeratosis and True Hermaphroditism  
Palmoplantar Hyperkeratosis with Squamous Cell Carcinoma of Skin and Sex Reversal  
palmoplantar keratoderma and congenital alopecia 2 
Palmoplantar Keratoderma, Nagashima Type  
Palmoplantar Keratoderma, Norrbotten Recessive Type 
Palmoplantar Keratoderma, Spastic Paralysis 
palmoplantar keratoderma-deafness syndrome  
palmoplantar keratoderma-esophageal carcinoma syndrome  
pancreatic squamous cell carcinoma 
papillary squamous carcinoma 
Papillon-Lefevre disease +   
PARC Syndrome 
Patel Bixler Syndrome 
penis squamous cell carcinoma +   
Perniola Krajewska Carnevale Syndrome 
pharynx squamous cell carcinoma +   
Pigmented Purpuric Eruption 
Pili Torti Onychodysplasia 
Pinheiro Freire-Maia Miranda Syndrome 
Porokeratosis 2, Palmar, Plantar, and Disseminated Type 
Powell Venencie Gordon syndrome 
Precocious Graying of Hair 
prostate squamous cell carcinoma  
punctate palmoplantar keratoderma +   
rectum squamous cell carcinoma +  
Red Skin Pigment Anomaly of New Guinea 
renal pelvis squamous cell carcinoma  
Russell-Silver Syndrome, X-Linked 
Santos Syndrome 
Satoyoshi Syndrome 
Schinzel-Giedion Syndrome  
Scholte Syndrome 
Schopf-Schulz-Passarge syndrome  
scrotum squamous cell carcinoma 
Short Stature, Onychodysplasia, Facial Dysmorphism, and Hypotrichosis  
skin squamous cell carcinoma +   
Skin/Hair/Eye Pigmentation, Variation In, 1  
Skin/Hair/Eye Pigmentation, Variation In, 10  
Skin/Hair/Eye Pigmentation, Variation In, 11  
Skin/Hair/Eye Pigmentation, Variation In, 4  
Skin/Hair/Eye Pigmentation, Variation In, 5  
Skin/Hair/Eye Pigmentation, Variation In, 6  
Skin/Hair/Eye Pigmentation, Variation In, 7  
Skin/Hair/Eye Pigmentation, Variation In, 8  
Skin/Hair/Eye Pigmentation, Variation In, 9  
Slti Salem Syndrome 
sphenoid sinus squamous cell carcinoma 
squamous cell bile duct carcinoma +   
Steatocystoma Multiplex with Natal Teeth 
Stern Lubinsky Durrie Syndrome 
stromal corneal pigmentation 
subglottis squamous cell carcinoma +  
supraglottis squamous cell carcinoma +  
Symmetric Acroleukopathy  
T-cell immunodeficiency, congenital alopecia, and nail dystrophy  
Tang Hsi Ryu Syndrome 
Teebi Kaurah Syndrome 
telogen effluvium 
Temple-Baraitser syndrome  
terminal osseous dysplasia  
Thumb Deformity and Alopecia 
Thumb Deformity, Alopecia, Pigmentation Anomaly 
thymus squamous cell carcinoma +  
Tonoki Syndrome 
tooth and nail syndrome  
Total Anonychia with Microcephaly 
Ulnar Hypoplasia with Mental Retardation 
Urban Schosser Spohn Syndrome  
ureter squamous cell carcinoma 
urethra squamous cell carcinoma +  
urticaria pigmentosa  
verrucous carcinoma +  
Vohwinkel syndrome  
vulva squamous cell carcinoma +   
Waardenburg Syndrome Type 4 +   
White Forelock with Malformations 
Whyte Murphy Syndrome 
Woodhouse-Sakati syndrome  
Woolly Hair, Hypotrichosis, Everted Lower Lip and Outstanding Ears 
X-linked reticulate pigmentary disorder  
xeroderma pigmentosum +   
yellow nail syndrome +  
Zori Stalker Williams Syndrome 

Exact Synonyms: CAPOK
Primary IDs: OMIM:618373

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