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Ontology Browser
Term:
Leukoencephalopathy, Motor Delay, Spasticity, and Dysarthria Syndrome (DOID:9006620)
Annotations: Rat: (1) Mouse: (1) Human: (1) Chinchilla: (1) Bonobo: (1) Dog: (1) Squirrel: (1) Pig: (1) Naked Mole-rat: (1) Green Monkey: (1)
Parent Terms Term With Siblings Child Terms
Dysarthria +     
Leukoencephalopathies +     
Muscle Spasticity +     
Acute Reversible Leukoencephalopathy with Increased Urinary Alpha-ketoglutarate  
adult-onset leukoencephalopathy with axonal spheroids and pigmented glia  
Adult-Onset Muscular Dystrophy with Leukoencephalopathy  
Auditory Perceptual Impairment 
Bahemuka Brown Syndrome 
brain small vessel disease 1  
Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy  
Cerebroretinal Microangiopathy with Calcifications and Cysts +   
Childhood-Onset Spasticity with Hyperglycinemia  
combined oxidative phosphorylation deficiency 12  
DEAFNESS, CONGENITAL, AND ADULT-ONSET PROGRESSIVE LEUKOENCEPHALOPATHY  
Demyelinating Autoimmune Diseases, CNS +   
Diaminopentanuria 
dystonia 9  
Early-Onset Progressive Encephalopathy with Brain Edema and/or Leukoencephalopathy +   
Encephalopathy, Spastic Tetraparesis, and Hypogonadism 
Episodic Mitochondrial Myopathy with or without Optic Atrophy and Reversible Leukoencephalopathy  
Fitzsimmons Walson Mellor Syndrome 
Fitzsimmons-Guilbert Syndrome 
Foix-Chavany-Marie Syndrome 
Hengel-Maroofian-Schols syndrome  
Hereditary Central Nervous System Demyelinating Diseases +   
Hereditary Diffuse Leukoencephalopathy with Spheroids 2  
hypomyelinating leukoencephalopathy 
Hypomyelination with Brainstem and Spinal Cord Involvement and Leg Spasticity  
inclusion body myopathy and brain white matter abnormalities  
INTELLECTUAL DISABILITY AND MYOPATHY SYNDROME  
Koone Rizzo Elias Syndrome 
Labrune Syndrome  
Leukoencephalopathy with Ataxia  
Leukoencephalopathy with Brainstem and Spinal Cord Involvement and Lactate Elevation  
Leukoencephalopathy with Dystonia and Motor Neuropathy  
leukoencephalopathy with vanishing white matter +   
Leukoencephalopathy, Arthritis, Colitis, and Hypogammaglobulinemia 
LEUKOENCEPHALOPATHY, DEVELOPMENTAL DELAY, AND EPISODIC NEUROLOGIC REGRESSION SYNDROME  
Leukoencephalopathy, Motor Delay, Spasticity, and Dysarthria Syndrome  
LEUKOENCEPHALOPATHY, PORPHYRIA-RELATED  
LEUKOENCEPHALOPATHY, PROGRESSIVE, INFANTILE-ONSET, WITH OR WITHOUT DEAFNESS  
Methylenetetrahydrofolate Reductase Deficiency  
Neurodevelopmental Disorder with Ataxic Gait, Absent Speech, and Decreased Cortical White Matter  
NEURODEVELOPMENTAL DISORDER WITH CARDIOMYOPATHY, SPASTICITY, AND BRAIN ABNORMALITIES  
NEURODEVELOPMENTAL DISORDER WITH CEREBELLAR HYPOPLASIA AND SPASTICITY  
Neurodevelopmental Disorder with Epilepsy, Spasticity, and Brain Atrophy  
NEURODEVELOPMENTAL DISORDER WITH HEARING LOSS AND SPASTICITY  
Neurodevelopmental Disorder with Microcephaly, Cortical Malformations, and Spasticity  
Neurodevelopmental Disorder with Progressive Spasticity and Brain White Matter Abnormalities  
neurodevelopmental disorder with spasticity and poor growth  
NEURODEVELOPMENTAL DISORDER WITH SPASTICITY, CATARACTS, AND CEREBELLAR HYPOPLASIA  
NEURODEVELOPMENTAL DISORDER WITH SPASTICITY, SEIZURES, AND BRAIN ABNORMALITIES  
NEURODEVELOPMENTAL DISORDER, NONPROGRESSIVE, WITH SPASTICITY AND TRANSIENT OPISTHOTONUS  
Oculopharyngeal Myopathy with Leukoencephalopathy 1  
Opticocochleodentate Degeneration 
Pontine Microangiopathy and Leukoencephalopathy, Autosomal Dominant  
Posterior Leukoencephalopathy Syndrome  
Powell Venencie Gordon syndrome 
progressive leukoencephalopathy with ovarian failure  
progressive multifocal leukoencephalopathy  
Ribose 5-Phosphate Isomerase Deficiency  
RNASET2-deficient cystic leukoencephalopathy  
Seemanova Lesny Syndrome 
sensory ataxic neuropathy, dysarthria, and ophthalmoparesis  
Severe Mental Retardation, with Spasticity and Pigmentary Tapetoretinal Degeneration 
spastic ataxia +   
spastic ataxia 3  
spastic paraplegia with deafness 
syndromic X-linked intellectual disability Turner type  
Telencephalic Leukoencephalopathy 
USMANI-RIAZUDDIN SYNDROME, AUTOSOMAL RECESSIVE  
vascular dementia +   
Webb-Dattani Syndrome  
Worster-Drought Syndrome  
X-linked intellectual disability-psychosis-macroorchidism syndrome  
X-linked Spondyloepimetaphyseal Dysplasia with Hypomyelinating Leukodystrophy  

Synonyms
Exact Synonyms: LEMSPAD ;   LEMSPAD syndrome
Broad Synonyms: EIF2AK1-related condition
Primary IDs: OMIM:618878

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