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Ontology Browser

Term:
progressive supranuclear palsy (DOID:678)
Annotations: Rat: (11) Mouse: (11) Human: (11) Chinchilla: (10) Bonobo: (11) Dog: (10) Squirrel: (9) Pig: (10)
Parent Terms Term With Siblings Child Terms
movement disease +     
ophthalmoplegia +     
tauopathy +     
Adenine Nucleotide Translocator Deficiency 
Akathisia, Drug-Induced 
Alopecia, Hypogonadism, Extrapyramidal Disorder 
Alzheimer's disease +   
Angelman syndrome  
ARTHROGRYPOSIS, PERTHES DISEASE, AND UPWARD GAZE PALSY  
basal ganglia calcification +   
basal ganglia cerebrovascular disease +  
benign shuddering attacks 
Beta-Ureidopropionase Deficiency  
biotin-responsive basal ganglia disease  
CANOMAD Syndrome 
chorea gravidarum 
choreatic disease +   
chronic progressive external ophthalmoplegia +   
congenital fibrosis of the extraocular muscles +   
congenital mirror movement disorder +   
Diffuse Neurofibrillary Tangles with Calcification 
distal arthrogryposis type 5  
Dyskinesias +   
dystonia +   
Dystonia Musculorum Deformans +   
DYSTONIA, CHILDHOOD-ONSET, WITH OPTIC ATROPHY AND BASAL GANGLIA ABNORMALITIES  
Early Onset Parkinsonism with Mental Retardation  
exophthalmic ophthalmoplegia 
External Ophthalmoplegia and Myopia 
External Ophthalmoplegia, Synergistic Divergence, Jaw Winking, and Oculocutaneous Hypopigmentation 
extrapyramidal and movement disease 
frontotemporal dementia +   
Gilles de la Tourette syndrome +   
guanidinoacetate methyltransferase deficiency  
Hamano Tsukamoto Syndrome 
Huntington's disease +   
Inclusion Body Myopathy 3, Autosomal Dominant  
internuclear ophthalmoplegia 
IVIC syndrome  
Meige syndrome 
Miles-Carpenter syndrome  
Minicore Myopathy with External Ophthalmoplegia  
mitochondrial DNA depletion syndrome 11  
Motor Neuron Disease with Dementia and Ophthalmoplegia 
multiple system atrophy +   
Neuhauser Eichner Opitz Syndrome 
neuroleptic malignant syndrome 
Non-Lissencephalic Cortical Dysplasia 
Ocular Myopathy with Curare Sensitivity 
Ophthalmoplegia Totalis with Ptosis and Miosis 
Ophthalmoplegia, Familial Static 
Ophthalmoplegia, Familial Total, with Iris Transillumination 
Ophthalmoplegic Migraine 
Ophthalmoplegic Neuromuscular Disorder with Abnormal Mitochondria 
Optic Atrophy, Deafness, Ophthalmoplegia, and Myopathy 
pantothenate kinase-associated neurodegeneration +   
Parkinsonian Disorders +   
Progressive External Ophthalmoplegia with Hypogonadism 
Progressive Ophthalmoplegia with Scrotal Tongue and Mental Deficiency 
Progressive Pallidal Degeneration with Retinitis Pigmentosa 
progressive supranuclear palsy +   
A degenerative disease of the central nervous system characterized by balance difficulties; OCULAR MOTILITY DISORDERS (supranuclear ophthalmoplegia); DYSARTHRIA; swallowing difficulties; and axial DYSTONIA. Onset is usually in the fifth decade and disease progression occurs over several years. Pathologic findings include neurofibrillary degeneration and neuronal loss in the dorsal MESENCEPHALON; SUBTHALAMIC NUCLEUS; RED NUCLEUS; pallidum; dentate nucleus; and vestibular nuclei. (From Adams et al., Principles of Neurology, 6th ed, pp1076-7)
Pronation-Supination Of The Forearm, Impairment Of 
Schimke X-Linked Mental Retardation Syndrome 
sensory ataxic neuropathy, dysarthria, and ophthalmoparesis  
Spastic Paraplegia with Associated Extrapyramidal Signs 
Stiff-Person syndrome  
syndromic X-linked intellectual disability 5  
Telfer Sugar Jaeger Syndrome 
tic disorder +   
Treft Sanborn Carey Syndrome 
Wilson disease +   
Woodhouse-Sakati Syndrome  

Synonyms
Exact Synonyms: PSNP1 ;   PSP ;   Progressive Supranuclear Ophthalmoplegia ;   Progressive Supranuclear Palsies ;   Richardson Syndrome ;   Richardson's Syndrome ;   Steele Richardson Olszewski Disease ;   Steele Richardson Olszewski Syndrome ;   Supranuclear Palsy, Progressive, 1
Primary IDs: MESH:D013494
Alternate IDs: OMIM:601104 ;   RDO:0003033
Xrefs: GARD:7471 ;   ICD10CM:G23.1 ;   NCI:C85028 ;   ORDO:683
Definition Sources: MESH:D013494, http://en.wikipedia.org/wiki/Progressive_supranuclear_palsy, http://www.ninds.nih.gov/disorders/psp/psp.htm

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.