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Term:
atypical hemolytic-uremic syndrome (DOID:0080301)
Annotations: Rat: (13) Mouse: (13) Human: (13) Chinchilla: (10) Bonobo: (9) Dog: (11) Squirrel: (8) Pig: (11)
Parent Terms Term With Siblings Child Terms
atypical hemolytic-uremic syndrome  
An hereditary hemolytic uremic syndrome associated with variations in the gene that encodes COMPLEMENT FACTOR H, or the related proteins CFHR1 and CFHR3. Disease often progresses to CHRONIC KIDNEY FAILURE without the prodromal symptoms of ENTEROCOLITIS and DIARRHEA that characterize typical hemolytic uremic syndrome.
C1 inhibitor deficiency +   
complement component 2 deficiency  
complement component 3 deficiency  
Complement Component 4, Partial Deficiency Of  
complement component 4A deficiency  
complement component 4B deficiency  
complement component 5 deficiency  
complement component 6 deficiency  
complement component 7 deficiency  
complement component 9 deficiency  
Complement Component C1r/C1s Deficiency +   
Complement Factor B Deficiency  
Complement Factor D Deficiency  
complement factor I deficiency  
Diarrhea prodrome + Hemolytic-Uremic Syndrome 
type I complement component 8 deficiency  
type II complement component 8 deficiency  

Synonyms
Exact Synonyms: AHUS, SUSCEPTIBILITY TO, 2 ;   AHUS, SUSCEPTIBILITY TO, 3 ;   AHUS, SUSCEPTIBILITY TO, 4 ;   AHUS, SUSCEPTIBILITY TO, 5 ;   AHUS, SUSCEPTIBILITY TO, 6 ;   AHUS1 ;   AHUS2 ;   AHUS3 ;   AHUS4 ;   AHUS5 ;   AHUS6 ;   Atypical Hemolytic-Uremic Syndromes ;   HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 1 ;   HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 2 ;   HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 3 ;   HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 4 ;   HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 5 ;   HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 6 ;   Hemolytic Uremic Syndrome, Atypical, Susceptibility To ;   Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 7 ;   Non Shiga Like Toxin Associated HUS ;   Non Stx Hus ;   Nonenteropathic HUS
Narrow Synonyms: AHUS, SUSCEPTIBILITY TO, 1 HEMOLYTIC UREMIC SYNDROME, TYPICAL
Primary IDs: MESH:D065766
Alternate IDs: OMIA:000636 ;   OMIM:235400 ;   OMIM:612922 ;   OMIM:612923 ;   OMIM:612924 ;   OMIM:612925 ;   OMIM:612926
Xrefs: GARD:8702
Definition Sources: https://ghr.nlm.nih.gov/condition/atypical-hemolytic-uremic-syndrome#sourcesforpage, https://rarediseases.info.nih.gov/diseases/8702/index#ref_2575, https://www.ncbi.nlm.nih.gov/pubmed/29226095

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.