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Ontology Browser

Term:
Parent Terms Term With Siblings Child Terms
diuretic +   
pteridines +     
2,4,7-trihydroxypteridine 
2,4-diamino-6,7-diisopropylpteridine 
2,4-diaminopteridine-6-carbaldehyde 
2-amino-6,7-dimethyl-4-oxo-8-(1'-D-ribityl)-4,8-dihydropteridine 
2-amino-6-(1-hydroxypropyl)-8-methylpteridine-4,7(3H,8H)-dione 
3-[2,4-diamino-7-(3-hydroxyphenyl)-6-pteridinyl]phenol 
4-\{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino\}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide 
4-amino-6,7-diphenyl-3H-pteridine-2-thione 
5,6,7,8-tetrahydropteridine 
5-(N,N-hexamethylene)amiloride  
5-(N-methyl-N-propyl)amiloride 
6,7-bis(4-aminophenyl)pteridine-2,4-diamine 
6,7-dihydropteridines +  
6,7-dimethyl-8-(1-D-ribityl)lumazine 
6-(hydroxymethyl)-8-(1-D-ribityl)lumazine 
6-methyl-7-oxo-8-(1-D-ribityl)lumazine (2-hydroxy tautomer) 
6-methyl-7-oxo-8-(1-D-ribityl)lumazine (2-oxo tautomer) 
7-(2-hydroxyethyl)-6-methyllumazine 
7-hydroxy-6-methyl-8-(1-D-ribityl)lumazine 
8-(1,2-dideoxy-1-D-ribityl)-7-methyllumazine 
8-(1,4-dideoxy-1-D-ribityl)-6-methyllumazine 
8-(1,4-dideoxy-1-D-ribityl)-7-methyllumazine 
8-(1,5-dideoxy-1-D-ribityl)-7-methyllumazine 
8-(2-hydroxyethyl)-6-methyllumazine 
8-(3-hydroxypropyl)-7-methyllumazine 
8-(4-hydroxybutyl)-6-methyllumazine 
8-(4-hydroxybutyl)-7-methyllumazine 
8-(5-hydroxypentyl)-7-methyllumazine 
acetazolamide +   
amiloride +   
amiloride hydrochloride +  
amiloride hydrochloride dihydrate 
bendroflumethiazide +   
benzthiazide 
bumetanide  
caffeine +   
carbamazepine +   
chlormerodrin +  
chlorothiazide 
cleistanthin A 
cleistanthin B +  
cocaine  
cyclothiazide  
diazoxide  
dihydroxypteridine +  
encainide +  
ethoxzolamide  
ethylisopropylamiloride  
Evans blue 
Evans blue free acid 
hydrochlorothiazide  
hydroflumethiazide 
icajine  
indapamide  
licarbazepine +  
loop diuretic +   
methotrexate  
metolazone  
osmotic diuretic +   
phenytoin  
pilsicainide 
potassium citrate (anhydrous) +   
potassium citrate monohydrate  
pralatrexate 
procainamide +   
pteridine 
pteridine-2,4,6,7-tetrol 
pterins +   
quinethazone 
quinidine +   
ranolazine  
reduced 6-(hydroxymethyl)-8-(1-D-ribityl)lumazine 
saxitoxin +   
solasodine  
spironolactone  
tocainide 
topiramate  
triamterene  
Pteridine substituted at positions 2, 4 and 7 with amino groups and at position 6 with a phenyl group. A sodium channel blocker, it is used as a diuretic in the treatment of hypertension and oedema.
trichlormethiazide  
trimethoprim +   
U50488  
U69593  
voltage-gated sodium channel blocker +   
xanthopterin-B2 

Synonyms
Exact Synonyms: 6-phenylpteridine-2,4,7-triamine
Related Synonyms: Formula=C12H11N7 ;   InChI=1S/C12H11N7/c13-9-7(6-4-2-1-3-5-6)16-8-10(14)18-12(15)19-11(8)17-9/h1-5H,(H6,13,14,15,17,18,19) ;   InChIKey=FNYLWPVRPXGIIP-UHFFFAOYSA-N ;   SMILES=C1=CC=C(C=C1)C2=NC3=C(N=C2N)N=C(N=C3N)N ;   triamterena ;   triamterenum
Alternate IDs: CHEBI:93604
Xrefs: CAS:396-01-0 ;   Drug_Central:2728 ;   KEGG:D00386 ;   LINCS:LSM-4060
Xref Mesh: MESH:D014223
Xrefs: PMID:26194642 ;   PMID:26385116 ;   PMID:27913567 ;   PMID:28166217 ;   PMID:28435224 ;   PMID:28588673 ;   Wikipedia:Triamterene

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.