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Term:
triamcinolone acetonide (CHEBI:71418)
Annotations: Rat: (29) Mouse: (29) Human: (29) Chinchilla: (0) Bonobo: (0) Dog: (0) Squirrel: (0) Pig: (0)
Parent Terms Term With Siblings Child Terms
20-oxo steroid +     
21-hydroxy steroid +     
cyclic ketal +     
glucocorticoid +     
pregnane +   
(1'S,5'S)-averufin 
(17Z)-3,11-dioxopregna-4,17(20)-dien-21-oic acid methyl ester 
(1R,9bR)-9b-fluoro-1,2,5,10-tetrahydroxy-1,9a,11a-trimethyl-2H,3H,3aH,3bH,4H,5H,8H,9H,10H,11H-cyclopenta[a]phenanthren-7-one 
(1S,5aR,9bR)-9b-fluoro-1-hydroxy-1,9a,11a-trimethyl-2H,3H,3aH,3bH,4H,5H,5aH,6H,8H,9H-cyclopenta[a]phenanthren-7-one 
(1S,5aS,9bR)-9b-fluoro-1-hydroxy-1,9a,11a-trimethyl-2H,3H,3aH,3bH,4H,5H,5aH,6H,8H,9H-cyclopenta[a]phenanthren-7-one 
(1S,9bR)-9b-fluoro-1,10-dihydroxy-1,9a-dimethyl-2H,3H,3bH,4H,5H,8H,9H,10H,11H-cyclopenta[a]phenanthren-7-one 
(1S,9bR)-9b-fluoro-1,5,10-trihydroxy-1,9a-dimethyl-2H,3H,3bH,4H,5H,5aH,6H,8H,9H,10H,11H-cyclopenta[a]phenanthren-7-one 
(1S,9bR)-9b-fluoro-1-hydroxy-1,9a,11a-trimethyl-decahydrocyclopenta[a]phenanthrene-5,7,10-trione 
(20R)-20-(carboxymethyl)oxypregn-4-en-3-one 
(20S)-20-(carboxymethyl)oxypregn-4-en-3-one 
(22S)-22-hydroxycampest-4-en-3-one 
(2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol 
(3S)-3-[(2S)-2-amino-4-hydroxy-3-oxobutyl]pyrrolidin-2-one 
(7R,9bR)-9b-fluoro-1,1,9a-trimethyl-2H,3H,3bH,4H,5H,7H,8H,9H,10H,11H-cyclopenta[a]phenanthrene-7,10-diol 
(8S,9S,10R,11S,13S,14R,17R)-11,17-dihydroxy-17-(2-hydroxy-1-oxoethyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one 
(8S,9S,10R,11S,13S,14R,17S)-11-hydroxy-17-(2-hydroxy-1-oxoethyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one 
(9bR)-9b-fluoro-5,10-dihydroxy-1,1,9a-trimethyl-2H,3H,3bH,4H,5H,8H,9H,10H,11H-cyclopenta[a]phenanthren-7-one 
(9R)-9-chloro-11,17-dihydroxy-17-(2-hydroxy-1-oxoethyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one 
(S)-carbinoxamine maleate 
1'H-5alpha-Cholest-2-eno[3,2-b]indole 
1,3-dihydroxybutan-2-one 
1-(4-\{[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy\}phenyl)-4-isopropylpiperazine +   
1-hydroxybutan-2-one 
1-O-demethyl-6-deoxydoxorubicin 
1-propyl-2-hydroxyacetylpyrrole 
11,17-dihydroxy-17-(2-hydroxy-1-oxoethyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one 
11,21-dioxoprogesterone 
11-dehydrocorticosterone  
11-deoxycorticosterone +   
11-deoxycorticosterone-21-hemisuccinate 
11-deoxycortisol  
11-oxotestosterone 
11alpha-hydroxyprogesterone +  
11alpha-hydroxyprogesterone hemisuccinate +  
11beta,17alpha,21-trihydroxypregnenolone 
11beta-hydroxy-17beta-estradiol 
11beta-hydroxyandrost-4-ene-3,17-dione 
11beta-hydroxyprogesterone 
11beta-hydroxytestosterone 
12alpha-hydroxy-3-oxochola-4,6-dien-24-oic acid +  
12alpha-Methylpregna-4,9(11)-diene-3,20-dione 
15alpha-hydroxytestosterone  
15beta-hydroxyprogesterone 
16,17-didehydropregnenolone +  
16,17-didehydropregnenolone 3-beta-D-glucoside 
16,17-didehydroprogesterone 
16alpha,17alpha-dihydroxyprogesterone acetophenide +  
16alpha-Hydroxycorticosterone 
16alpha-hydroxytestosterone  
16beta-fluoro-17beta-hydroxyandrost-4-en-3-one propionate 
16beta-hydroxyestradiol +  
16beta-hydroxytestosterone 
16beta-methylpregn-4-ene-3,20-dione 
17,20-dihydroxypregn-4-en-3-one +   
17,21-dihydroxy-5beta-pregnane-3,11,20-trione  
17,21-Epoxy-9-fluoro-11beta-hydroxypregn-4-ene-3,20-dione 
17-hydroxy-17-(2-hydroxy-1-oxoethyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one 
17-hydroxypregnenolone 3-sulfate 
17-hydroxyprogesterone 3-O-(carboxymethyl)oxime 
17alpha,21-dihydroxypregnenolone 
17alpha-hydroxypregn-5-ene-3,20-dione 
17beta-hydroxy-2alpha,17-dimethylestr-4-en-3-one 
17beta-hydroxy-2alpha-methylestr-4-en-3-one 
18-hydroxycorticosterone 
19-hydroxydeoxycorticosterone 
19-hydroxytestosterone 
1alpha-hydroxyandrost-4-ene-3,17-dione 
1beta-hydroxytestosterone 
1S,7R,9bR)-9b-fluoro-1,9a,11a-trimethyl-2H,3H,3aH,3bH,4H,5H,7H,8H,9H,10H,11H-cyclopenta[a]phenanthrene-1,7,10-triol 
2',4,4',6'-tetrahydroxychalcone +   
2',4,4',6'-tetrahydroxychalcone(1-) 
2,4'-dihydroxyacetophenone 
2,5-dioxo-1-pyrrolidinyl 6-(6-\{3-[(progesterone-4-yl)thiopropionyl]aminohexanoyl\}amino)hexanoate 
2-hydroxyacetophenone 
2-hydroxytestosterone +  
2-methoxyidazoxan  
20,21,21-Trifluoro-3-methoxy-19-nor-17alpha-pregna-1,3,5(10),20-tetraen-17-ol 
20-hydroxy-3-oxopregn-4-en-21-al 
20-hydroxypregn-4-en-3-one +   
20beta-dihydrocortisol 
21-acetoxy-11beta,17-dihydroxy-6alpha-methylpregn-4-ene-3,20-dione 
21-dehydrocortisol  
21-dehydrocortisone 
21-deoxycortisol 
21-Hydroxy-5beta-pregnane-3,11,20-trione 
21-hydroxy-C21-steroid 
21-hydroxypregnenolone +  
21-hydroxypregnenolone disulfate 
21-phosphorifampicin 
22-deoxy-20,21-dihydroxyecdysone 
24-ethylcholesta-4,22-dien-3-one 
26-hydroxycholest-4-en-3-one +  
27-O-demethylrifamycin SV 
2alpha-fluoro-17beta-hydroxyandrost-4-en-3-one 
2alpha-hydroxytestosterone 
2beta,21-Dihydroxypregn-4-ene-3,20-dione 
3'-deamino-3'-(3-cyanomorpholin-4-yl)doxorubicin  
3,17-dioxoandrost-4-en-19-al 
3,4-O-[(1S)-1-carboxyethylidene]-beta-D-galactose 
3,6-Dimethoxy-19-norpregna-1,3,5,7,9-pentaen-20-one 
3-(2,4-Cyclopentadien-1-ylidene)pregn-4-en-20-one 
3-(progesterone-4-yl)thiopropionic acid 
3-(progesterone-7alpha-yl)thiopropionic acid 
3-hydroxypregnan-20-one +   
3-hydroxypyruvic acid  
3-ketocholest-4-en-26-al +  
3-Methoxy-19-nor-17alpha-pregna-1,3,5(10),20-tetraen-17-ol 
3-Methoxy-19-nor-17alpha-pregna-1,3,5(10)-trien-17beta-ol 
3-Methoxy-19-norpregna-1,3,5(10)-trien-20-one 
3-Methyl-19-nor-17alpha-pregna-1,3,5(10)-trien-17-ol 
3-oxo-23,24-bisnorchol-4-en-22-oic acid +  
3-oxo-23,24-bisnorchola-1,4-dien-22-oic acid 
3-oxo-Delta(1),Delta(4)-steroid +   
3-oxochola-4,6-dien-24-oic acid 
3a,7b,21-trihydroxy-5b-cholanoic acid 
3alpha,11beta,21-Trihydroxy-20-oxo-5beta-pregnan-18-al 
3alpha,12alpha-dihydroxy-5beta-pregnan-20-one diacetate 
3alpha,17alpha,21-Trihydroxy-5beta-pregnan-20-one 
3alpha,20alpha,21-Trihydroxy-5beta-pregnane-11-one 
3alpha,21-Dihydroxy-5beta-pregnane-11,20-dione 
3beta,21-Dihydroxy-4,4,14-trimethyl-5alpha-pregn-8-en-20-one 
3beta-(1-Pyrrolidinyl)-5alpha-pregnane-11,20-dione 
3beta-Fluoro-5beta-pregnan-20-one 
3beta-hydroxy-16alpha,17alpha-epoxypregnenolone +  
3beta-hydroxy-16alpha,17alpha-epoxypregnenolone 3-beta-D-glucoside 
3beta-hydroxy-5alpha-pregnan-20-one hemisuccinate 
3beta-hydroxy-5beta-pregnan-20-one hemisuccinate 
4'-deoxy-4'-iododoxorubicin 
4'-epidoxorubicin  
4,5-dihydrocortisone +   
4,5alpha-dihydrocortisone 
4,6-pyr-beta-D-GlcpNAc-(1->3)-alpha-D-Galp-(1->4)-beta-L-Rhap 
4-Methyl-4-aza-5-pregnene-3,20-dione 
4-pregnen-20,21-diol-3-one 
4-pregnen-3beta-ol-20-one 
4-Pregnene-16alpha,21-diol-3,20-dione 
4beta,5beta-Epoxypregnane-3,20-dione 
5-alpha-THDOC  
5alpha-Dihydrodeoxycorticosterone 
5alpha-Pregn-2-en-20-one 
5alpha-pregnane +   
5alpha-pregnane-3,20-dione  
5beta-dihydroaldosterone 
5beta-dihydrocorticosterone 
5beta-dihydrocortisol 
5beta-dihydrodeoxycorticosterone 
5beta-pregn-11-ene-3,20-dione 
5beta-pregnane +   
5beta-pregnane-3,20-dione 
6'-O-acetylpaeoniflorin 
6-(6-\{3-[(progesterone-4-yl)thiopropionyl]aminohexanoyl\}amino)hexanoic acid 
6-\{3-[(progesterone-4-yl)thiopropionyl]amino\}hexanoic acid 
6-dehydrotestosterone +  
6-methylprednisolone +   
6alpha-fluoro-17-hydroxycorticosterone 21-acetate 
6alpha-Fluoroprednisolone 
6alpha-Hydroxycortisol 
6alpha-methylprednisolone +   
6beta,16alpha,17alpha-trihydroxyprogesterone 
6beta-hydroxyandrost-4-ene-3,17-dione 
6beta-hydroxycortisol  
6beta-hydroxycortisone 
6beta-hydroxyprogesterone +  
6beta-hydroxyprogesterone hemisuccinate 
6beta-hydroxytestosterone +   
7-epiclusianone 
7alpha -hydroxytestosterone 
7alpha,12alpha,24-trihydroxycholest-4-en-3-one +  
7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oic acid +  
7alpha,12alpha-dihydroxycholest-4-en-3-one 
7alpha,24-dihydroxycholest-4-en-3-one +  
7alpha,25-dihydroxy-4-cholesten-3-one 
7alpha,26-dihydroxycholest-4-en-3-one 
7alpha-hydroxy-3-oxo-4-cholestenoic acid 
7alpha-hydroxy-3-oxochol-4-en-24-oic acid 
7alpha-hydroxyandrost-4-ene-3,17-dione 
7alpha-hydroxycholest-4-en-3-one  
7alpha-hydroxypregnenolone 
9,11alpha-epoxypregn-4-ene-3,20-dione 
9-fluoro-11,17-dihydroxy-17-(2-hydroxy-1-oxoethyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one 
9-fluoro-11beta,17,21-trihydroxy-2alpha-methylpregn-4-ene-3,20-dione 21-acetate 
9-Fluoro-11beta,21-dihydroxy-16alpha,17-(isopropylidenedioxy)pregn-4-ene-3,20-dione 
9-Fluoro-11beta-hydroxypregna-4,16-diene-3,20-dione 
9-fluoro-17-methyl-5beta-androstane-3alpha,11beta,17beta-triol 
9-fluoro-2alpha-methylpregn-4-ene-3,11,20-trione 
9-Fluoroprednisolone 
9alpha,11alpha-dihydroxyergosta-4,6,8(14),22-tetraen-3-one 
9alpha-Fluoro-11beta,16alpha,17alpha,21-tetrahydroxypregn-4-ene-3,20-dione 
9alpha-Fluoro-11beta,17alpha,21-trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione 
9alpha-hydroxy-3-oxo-23,24-bisnorchol-4-en-22-oic acid 
9alpha-hydroxy-3-oxo-23,24-bisnorchola-1,4-dien-22-oic acid 
9alpha-hydroxyandrost-4-en-3,17-dione 
A-norpregn-3(5)-ene-2,20-dione 
acroptilin 
adrenosterone  
aflatoxin B1 endo-8,9-oxide 
aflatoxin M1 8,9-epoxide 
alcaftadine 
alclometasone 
alclometasone dipropionate  
aldosterone +   
aldosterone hemiacetal 
algestone +  
algestone acetonide 
algestone acetophenide 
amcinonide 
AMG-925 
amlexanox  
amomol A 
amomol B 
andrographolide  
androst-4-ene-3,17-dione +   
androsta-1,4-diene-3,17-dione 
asparagoside F 
aspirin-triggered resolvin D1 
astemizole  
avermectin +   
avermectin analogue +   
azaconazole 
azatadine +   
azatadine maleate 
azelastine +   
azelastine hydrochloride 
beclomethasone +   
beclomethasone dipropionate 
bepotastine 
bepotastine besylate 
betamethasone +   
betamethasone acetate 
betamethasone acibutate 
betamethasone benzoate 
betamethasone dipropionate +   
betamethasone phosphate 
betamethasone valerate  
Breo Ellipta 
brompheniramine +   
brompheniramine maleate +  
budesonide  
calotropone 
canrenoic acid  
capsiate  
carbinoxamine +   
carbinoxamine maleate +  
caudatin-3-O-beta-cymaropyranoside 
celastrol  
cetirizine  
chaetoxanthone A 
chaetoxanthone B 
chloroprednisone 
chlorphenamine +   
cholest-4-en-3-one +   
cholesta-1,4,22-trien-3-one 
cinnarizine  
clemastine +   
clemastine fumarate 
clobetasol +   
clobetasol propionate 
clocortolone +  
clocortolone pivalate 
cloprednol 
cortancyl 
cortexolone 
corticosterone +   
cortisol +   
cortisol 17-butyrate 
cortisol 17-valerate 
cortisol 21-sulfate 
cortisol phosphate 
cortisone +   
cortivazol  
Cortol 
Cortolone 
cyasterone 
cyproheptadine +   
cyproheptadine hydrochloride sesquihydrate 
cyproterone +   
cyproterone acetate  
danazol  
danielone 
dapsone +   
davidigenin 
Delta(1)-progesterone +   
Delta(4)-dafachronic acid +  
demegestone 
deoxycortisol +   
desloratadine  
desonide 
desoximetasone  
dexamethasone +   
dexamethasone phosphate  
dexamethasone valerate 
dexbrompheniramine +   
dexbrompheniramine maleate 
dichotomoside D 
dienogest  
difenoconazole  
diflorasone +   
diflorasone diacetate 
diflucortolone 
dihydroxyacetone +   
dihydroxyacetone phosphate  
dioxygen +   
diphenhydramine +   
diphenhydramine hydrochloride 
diphenhydramine salicylate 
dotarizine 
doxorubicin +   
doxylamine  
drospirenone  
dydrogesterone  
E3040 +   
ebselen  
EET +   
emedastine +   
emedastine difumarate 
epinastine +   
epitestosterone +   
eplerenone  
ergosta-4,6,8(14),22-tetraen-3-one  
eribulin 
erythrulose +  
estra-1(10),4-diene-2,3,17-trione 
etaconazole 
ethisterone 
ethyl [4-(\{[2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl\}sulfanyl)phenyl]carbamate +  
etonogestrel  
fexofenadine 
fluclorolone 
fluclorolone acetonide 
fludrocortisone +   
fludrocortisone acetate 
flumethasone +   
flumethasone pivalate 
flunisolide  
Fluocinolone 
fluocinolone acetonide  
fluocortolone 
fluorometholone +   
fluorometholone acetate 
fluoxymesterone  
fluperolone 
fluprednidene 
Flurandrenolide  
fluticasone +   
fluticasone furoate +  
fluticasone propionate 
formestane  
formocortal 
friedelin +  
fruticoside A 
fucodiphloroethol G 
Funtumine 
ganodesterone 
ginsenoside C-K  
ginsenoside Rb1  
ginsenoside Rd +   
glucosyl-6beta-hydroxytestosterone 
glucosyltestosterone 
glycerone sulfate 
halometasone 
halosterol A 
hookerianamide K 
hydrangenol +  
hydrocortamate +  
hydrocortisone caproate 
hydroxyacetone +  
hydroxypregnenolone +   
hydroxypyruvaldehyde 
itraconazole  
jaceosidin  
kidjoranin-3-O-alpha-diginopyranosyl-(1->4)-beta-cymaropyranoside 
kidjoranin-3-O-beta-digitoxopyranoside 
lactiflorin 
LD-norgestrel 
levonorgestrel  
lifitegrast 
loteprednol +   
loteprednol etabonate  
LSM-1835 
LSM-5687 
lupeol +   
medroxyprogesterone +   
medroxyprogesterone acetate  
megestrol +   
meprednisone  
methapyrilene +   
methapyrilene hydrochloride 
methyl prednisolone-16-carboxylate +  
methyl prednisolone-16alpha-carboxylate 
methylprednisolone acetate 
methyltestosterone  
mibolerone  
mifepristone  
mometasone +   
mometasone furoate  
myricitrin +   
N-Methylindolo[3,2-b]-5alpha-cholest-2-ene 
nandrolone +   
NCS172285 
nedocromil  
nemorubicin  
non-steroidal anti-inflammatory drug +   
norethisterone +   
norethisterone acetate 
norgestrel +   
O-alkylglycerone +  
Osaterone acetate 
oxytetracycline  
palmitoyl ethanolamide  
Paramethasone 
pederin 
pentagestrone 
pentanoic acid [11-hydroxy-17-(2-hydroxy-1-oxoethyl)-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] ester 
petasin 
poststerone 
prednisolone +   
prednisolone phosphate 
prednisolone sodium phosphate 
prednisolone-16-carboxylic acid +  
prednisolone-16alpha-carboxylic acid +  
prednisone +   
prednival 
prednylidene  
pregn-4-en-3-one 
pregn-5-ene-3,20-dione 
Pregna-4,11-diene-3,20-dione 
Pregna-4,16-diene-3,11,20-trione 
pregna-4,9(11)-diene-3,20-dione 
pregnan-21-al 
pregnan-21-ol 
pregnane derivative +  
pregnenolone +   
pregnenolone 3-beta-D-glucoside 
probucol  
progesterone +   
progesterone 3-O-(carboxymethyl)oxime +  
promegestone  
promethazine  
promethazine hydrochloride 
propiconazole  
rhinacanthin D 
rhodiocyanoside A 
rifampicin +   
rifamycin SV +   
rifamycin SV hemiaminal 
rifaximin  
rimexolone  
rizatriptan 
rottlerin  
sappanchalcone  
secoxyloganin 
spiroketal +   
spironolactone  
stachsterol 
streptolydigin 
testololactone 
testosterone +   
testosterone acetate 
testosterone sulfate 
Tetrahydrocorticosterone 
tetrahydrocortisol 
thalidomide +   
tixocortol +  
tixocortol pivalate 
topiramate  
torososide B 
tranilast  
triamcinolone +   
triamcinolone acetonide  
A synthetic glucocorticoid that is the 16,17-acetonide of triamcinolone. Used to treat various skin infections.
trimegestone  
ulipristal acetate 
Urocortisone 
VX-745  
withalongolide C 
withalongolide E 
zaragozic acid A +   
zaragozic acid C 
zolmitriptan  

Synonyms
Exact Synonyms: (4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS)-4b-fluoro-6b-glycoloyl-5-hydroxy-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
Related Synonyms: (11beta,16alpha)-9-fluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione ;   9-fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione-16,17-acetonide ;   9alpha-fluoro-11beta,21-dihydroxy-16alpha,17-isopropylidenedioxy-1,4-pregnadiene,3,20-dione ;   9alpha-fluoro-11beta,21-dihydroxy-16alpha,17alpha-isopropylidenedioxypregna-1,4-diene-3,20-dione ;   9alpha-fluoro-16alpha-17alpha-isopropyledenedioxyprednisolone ;   9alpha-fluoro-16alpha-17alpha-isopropylidenedioxy-Delta-1-hydrocortisone ;   9alpha-fluoro-16alpha-hydroxyprednisolone 16alpha,17alpha-acetonide ;   Formula=C24H31FO6 ;   InChI=1S/C24H31FO6/c1-20(2)30-19-10-16-15-6-5-13-9-14(27)7-8-21(13,3)23(15,25)17(28)11-22(16,4)24(19,31-20)18(29)12-26/h7-9,15-17,19,26,28H,5-6,10-12H2,1-4H3/t15-,16-,17-,19+,21-,22-,23-,24+/m0/s1 ;   InChIKey=YNDXUCZADRHECN-JNQJZLCISA-N ;   SMILES=[H][C@@]12C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C ;   Triamcinolone 16,17-acetonide
Alternate IDs: CHEBI:9668
Xrefs: CAS:76-25-5 ;   DrugBank:DB00620 ;   Drug_Central:2726 ;   KEGG:C08183 ;   KEGG:D00983
Xref Mesh: MESH:D014222
Xrefs: Patent:US2008118586 ;   Patent:US2008139545 ;   Reaxys:60069 ;   VSDB:3009 ;   Wikipedia:Triamcinolone_acetonide

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.