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Ontology Browser
Term:
Parent Terms Term With Siblings Child Terms
3,4-dimethylindolyl precursor of nosiheptide 
3-methylindolyl precursor of nosiheptide 
A41030A 
A47934 
aculeacin A 
alpha-amanitin  
Amaninamide 
anidulafungin 
AP4 hapten 
calcitonin  
carbetocin 
chloroorienticin B 
chloropeptin I 
chloropeptin II 
CIGB-300 
cinnamycin 
complestatin A 
complestatin B 
curacozole 
daptomycin 
demoxytocin 
desirudin 
desmopressin +   
devancoaminyl vancomycin 
DPDPE  
felypressin 
fusaripeptide A 
insulin +   
isocomplestatin 
lancovutide 
lepirudin  
linaclotide 
A fourteen-membered heterodetic cyclic peptide consisting of Cys, Cys, Glu, Tyr, Cys, Cys, Asn, Pro, Ala, Cys, Thr, Gly, Cys and Tyr residues joined in sequence and cyclised by three disulfide bonds: between Cys(1) and Cys(6), between Cys(2) and Cys(10), and between Cys(5) and Cys(13). Used for treatment of irritable bowel syndrome accompanied by constipation.
microcystin +   
motixafortide +  
omega-conotoxin GVIA  
omega-conotoxin MVIIA 
oxytocin +   
peginesatide 
polymyxin +   
ristocetin 
somatostatin +   
somatostatin-28 
SW-163E 
syringomycin +  
thiazomycin 
thiostrepton  
UK 63052 
UK 63598 
UK 65662 
ustiloxin B 
vancomycin aglycone +   
vasopressin +   
vasotocin  
victorin C 
viomycin +  
YM-216391 

Synonyms
Related Synonyms: Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr (disulfide bridge: 1-6; 2-10; 5-13) ;   Formula=C59H79N15O21S6 ;   InChI=1S/C59H79N15O21S6/c1-26-47(82)69-41-25-101-99-22-38-52(87)65-33(13-14-45(80)81)49(84)66-34(16-28-5-9-30(76)10-6-28)50(85)71-40(54(89)72-39(23-97-96-20-32(60)48(83)70-38)53(88)67-35(18-43(61)78)58(93)74-15-3-4-42(74)56(91)63-26)24-100-98-21-37(64-44(79)19-62-57(92)46(27(2)75)73-55(41)90)51(86)68-36(59(94)95)17-29-7-11-31(77)12-8-29/h5-12,26-27,32-42,46,75-77H,3-4,13-25,60H2,1-2H3,(H2,61,78)(H,62,92)(H,63,91)(H,64,79)(H,65,87)(H,66,84)(H,67,88)(H,68,86)(H,69,82)(H,70,83)(H,71,85)(H,72,89)(H,73,90)(H,80,81)(H,94,95)/t26-,27+,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-,46-/m0/s1 ;   InChIKey=KXGCNMMJRFDFNR-WDRJZQOASA-N ;   L-cysteinyl-L-cysteinyl-L-alpha-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-L-tyrosine cyclic (1->6),(2->10),(5->13)-tris(disulfide) ;   Linzess ;   SMILES=[H][C@]1(CSSC[C@]2([H])NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](C)NC(=O)[C@@H]4CCCN4C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CSSC[C@H](N)C(=O)N3)NC2=O)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)NCC(=O)N1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Xrefs: CAS:851199-59-2 ;   KEGG:D09355 ;   PMID:19706070 ;   PMID:20307554 ;   PMID:20377786 ;   PMID:20560145 ;   PMID:20863829 ;   PMID:21185863 ;   PMID:21205879 ;   PMID:21382586 ;   PMID:21446888 ;   PMID:21616041 ;   PMID:21651347 ;   PMID:21830967 ;   PMID:22045908 ;   PMID:22114754 ;   PMID:22114756 ;   PMID:22149576 ;   PMID:22462039 ;   PMID:22553939 ;   PMID:22807692 ;   PMID:22918691 ;   PMID:22986437 ;   PMID:22986440 ;   Patent:MX2012001660 ;   Patent:WO2012021715 ;   Wikipedia:Linaclotide

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