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Ontology Browser

Term:
(2R,3S)-2-hydroxy-3-methylpentanoic acid (CHEBI:55536)
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Parent Terms Term With Siblings Child Terms
(2R)-3-(3,4-dihydroxyphenyl)lactic acid 
(2R,3R)-2,3-dihydroxy-3-methylpentanoic acid 
(2R,3R)-2-hydroxy-3-methylpentanoic acid 
(2R,3S)-2-hydroxy-3-methylpentanoic acid 
A valeric acid derivative having an (R)-hydroxy substituent at the 2-position and an (S)-methyl substituent at the 3-position; one of 4 steroisomers of 2-hydroxy-3-methylpentanoic acid, generated by isoleucine metabolism. Found at significantly higher levels than normal in patients with maple syrup urine disease (MSUD).
(2S)-2-[(R)-1-carboxyethylamino]pentanoic acid 
(4R)-4-hydroxypentanoic acid +  
(R)-2-hydroxy-4-(hydroxymethylphosphinyl)butyric acid 
(R)-2-hydroxy-4-methylpentanoic acid +  
(R)-2-hydroxynonanoic acid 
(R)-3-(5-benzyloxyindol-3-yl)lactic acid 
(R)-3-phenyllactic acid 
(R)-indole-3-lactic acid 
(S)-4-amino-5-oxopentanoic acid 
1-octadecanoyl-2-pentanoyl-sn-glycero-3-phosphocholine 
1-palmitoyl-2-valeroyl-sn-glycero-3-phosphocholine 
2,3,4-trihydroxypentanoic acid 
2,5-dioxopentanoic acid 
2-amino-4-oxopentanoic acid +  
2-aminopentanoic acid +   
2-hydroxy-4-methylvalerate +  
2-hydroxy-4-methylvaleric acid +   
2-hydroxypentanoic acid +  
2-methyl-3-ketovaleric acid 
2-phenylethyl pentanoate 
3-hydroxy-3-methyl-2-oxopentanoic acid +  
3-hydroxypentanoic acid +  
3-mercaptolactic acid 
3-methyl-2-oxovaleric acid +   
4,5-dioxopentanoic acid 
4-hydroxy-2-oxopentanoic acid +  
4-methyl-2-oxopentanoic acid  
4-methyl-3-oxopentanoic acid 
5-(2,3-dimethoxy-4-methylphenyl)pentanoic acid 
5-[(1-phenylcyclohexyl)amino]pentanoic acid 
5-[(4-nitrobenzyl)(phosphonomethyl)amino]valeric acid 
5-\{3-[(2,4-diaminopyrimidin-5-yl)methyl]-4-methoxyphenoxy\}pentanoic acid 
5-amino-2-oxopentanoic acid 
5-aminopentanoic acid +  
5-guanidino-2-oxopentanoic acid 
5-guanidino-3-methyl-2-oxopentanoic acid 
5-hydroxypentanoic acid +  
5-phenylpentanoic acid 
acetylpyruvic acid +  
ethyl (4R)-4-[((2R,5S)-2-(4-fluorobenzyl)-6-methyl-5-\{[(5-methylisoxazol-3-yl)carbonyl]amino\}-4-oxoheptanoyl)amino]-5-[(3S)-2-oxopyrrolidin-3-yl]pentanoate 
gemfibrozil  
mevaldic acid 
mevalonic acid +   
O-valeroylcarnitine +  
oxopentanoic acid +   
p-N,N-bis(2-chloroethyl)aminophenylvaleric acid 
pentanamide +  
pentanoyl-CoA +  
perfluoropentanoic acid  
valeryl group 
valproic acid +   

Synonyms
Related Synonyms: (2R,3S)-2-hydroxy-3-methylvaleric acid ;   (2R,3S)-HMVA ;   (2R,3S)-isoleucic acid ;   (R,S)-isoleucic acid ;   Formula=C6H12O3 ;   HMVA ;   InChI=1S/C6H12O3/c1-3-4(2)5(7)6(8)9/h4-5,7H,3H2,1-2H3,(H,8,9)/t4-,5+/m0/s1 ;   InChIKey=RILPIWOPNGRASR-CRCLSJGQSA-N ;   SMILES=CC[C@H](C)[C@@H](O)C(O)=O
Xrefs: Beilstein:1721800 ;   PMID:1429566
Cyclic Relationships: is_conjugate_acid_of CHEBI:55537

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.