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Term:
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor (CHEBI:50750)
Annotations: Rat: (2772) Mouse: (2782) Human: (2826) Chinchilla: (0) Bonobo: (0) Dog: (2) Squirrel: (0) Pig: (9)
Parent Terms Term With Siblings Child Terms
2,2,3,3-tetrahydroxy-2,3-dihydronaphthalene-1,4-dione 
actinodaphnine 
EC 5.99.1.2 (DNA topoisomerase) inhibitor +   
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor +   
A topoisomerase inhibitor that inhibits DNA topoisomerase (ATP-hydrolysing), EC 5.99.1.3 (also known as topoisomerase II and as DNA gyrase), which catalyses ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands.
topoisomerase IV inhibitor +   

Synonyms
Related Synonyms: DNA gyrase inhibitor ;   DNA gyrase inhibitors ;   DNA topoisomerase (ATP-hydrolysing) inhibitor ;   DNA topoisomerase (ATP-hydrolysing) inhibitors ;   DNA topoisomerase II inhibitor ;   DNA topoisomerase II inhibitors ;   EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitors ;   EC 5.99.1.3 inhibitor ;   EC 5.99.1.3 inhibitors ;   inhibitor of type II topoisomerase ;   inhibitors of type II topoisomerase ;   topoisomerase II inhibitor ;   topoisomerase II inhibitors ;   type II DNA topoisomerase inhibitor ;   type II DNA topoisomerase inhibitors
Alternate IDs: CHEBI:132229 ;   CHEBI:50234

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.