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Parent Terms Term With Siblings Child Terms
(+)-(12E,2S,3S,4R,5R,6R,9S,11S,15R)-3-benzoyloxy-5,6-epoxylathyr-12-en-15-ol-14-one 
(+-)-menthol 
(-)-(12E,2S,3S,4R,5R,6R,9S,11S,15R)-3-acetoxy-15-benzoyloxy-5,6-epoxylathyr-12-en-14-one 
(-)-(5E,12E,2S,3S,4S,9S,11S,15R)-15-benzoyloxylathyra-5,12-dien-3-ol-14-one 
(-)-(6Z,12E,2S,3S,4R,5R,9S,11S,15R)-3-acetoxy-15-benzoyloxylathyra-6,12-dien-5-ol-14-one 
(-)-(6Z,12E,2S,3S,4R,5R,9S,11S,15R)-5-acetoxy-15-benzoyloxylathyra-6,12-dien-3-ol-14-one 
(2R,3S)-EHNA 
(2R,3S)-EHNA hydrochloride 
(E)-cinnamaldehyde +   
(R)-adrenaline +   
(R)-methocarbamol +  
(S)-glaucine +   
(S)-methocarbamol +  
1',3'-dimethylspiro[1H-indole-3,8'-7,9-dihydropurine]-2,2',6'-trione 
1,3,7,9-tetramethyluric acid 
1,3,7-trimethyl-5-hydroxyisouric acid 
1,3,7-trimethyl-8-(phenylmethyl)purine-2,6-dione 
1,3,7-trimethylisoguanine 
1,3,7-trimethyluric acid  
1,3-dibutyl-7-(2-oxopropyl)purine-2,6-dione 
1,3-dimethyl-7-(5-oxohexyl)purine-2,6-dione 
1,3-dimethyl-7-(phenylmethyl)-8-[2-(thiophen-2-ylmethylidene)hydrazinyl]purine-2,6-dione 
1,3-dimethyl-8-(3-methyl-1-piperidinyl)-7-[2-[(5-methyl-1,3,4-thiadiazol-2-yl)thio]ethyl]purine-2,6-dione 
1,3-dimethyl-8-[2-(1-pyrrolidinyl)ethylthio]-6-sulfanylidene-7H-purin-2-one 
1,3-dimethyl-8-[[methyl-(phenylmethyl)amino]methyl]-7-(2-methylpropyl)purine-2,6-dione 
1,3-dimethyl-8-[methyl-(phenylmethyl)amino]-7-[2-(2-pyrimidinylthio)ethyl]purine-2,6-dione 
1,3-dimethyluric acid 
1,3-dinitroglycerol +  
1,7-dimethyluric acid  
1-methyl-3-propyl-7H-xanthine 
1-methyluric acid  
15beta-O-benzoyl-5alpha-hydroxyisolathyrol 
2',3'-secoguanosine 
2,3-bis(4-hydroxyphenyl)-1,2-propanediol 
2-(1,3-dimethyl-2,6-dioxo-7-purinyl)-N'-[2-(2-ethoxyphenoxy)-1-oxoethyl]acetohydrazide 
2-(1,3-dimethyl-2,6-dioxo-7-purinyl)-N-(phenylmethyl)-N-(2-pyridinyl)acetamide 
2-(1,3-dimethyl-2,6-dioxo-7-purinyl)-N-[3-[(4-methoxyphenyl)sulfamoyl]-4-methylphenyl]acetamide 
2-(1,3-dimethyl-2,6-dioxo-7-purinyl)acetic acid 
2-(\{8-[(3R)-3-aminopiperidin-1-yl]-1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl\}methyl)benzonitrile 
2-[(1,3-dimethyl-2,6-dioxo-7-propyl-8-purinyl)thio]-N-(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)acetamide 
2-[(7-ethyl-1,3-dimethyl-2,6-dioxo-8-purinyl)thio]-N-(6-methyl-2-pyridinyl)acetamide 
2-[[3-methyl-7-(3-methylbutyl)-2,6-dioxo-8-purinyl]thio]propanoic acid methyl ester 
2-[[7-(3-chlorobut-2-enyl)-3-methyl-2,6-dioxo-8-purinyl]thio]butanoic acid ethyl ester 
2-furancarboxylic acid [4-[[[1,3-dimethyl-2,6-dioxo-7-(phenylmethyl)-8-purinyl]hydrazinylidene]methyl]phenyl] ester 
2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine 
2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine  
3,5-dimethyl-4-isoxazolecarboxylic acid (3-butyl-2,6-dioxo-7-propyl-8-purinyl)methyl ester 
3,7-dimethyl-1-(phenylmethyl)-8-[(phenylmethyl)amino]purine-2,6-dione 
3,7-dimethylisoguanine 
3,7-dimethyluric acid 
3-butyl-8-(2-fluorophenyl)-7-(phenylmethyl)purine-2,6-dione 
3-isobutyl-1-methylxanthine +   
3-methyl-7-(2-phenylethyl)-8-(propylamino)purine-2,6-dione 
3-methyl-7-(phenylmethyl)-8-(propan-2-ylthio)purine-2,6-dione 
3-methyl-7-[(4-methylphenyl)methyl]-8-[2-(1-piperidinyl)ethylthio]purine-2,6-dione 
3-methyl-7-pentyl-8-(2-phenylethylthio)purine-2,6-dione 
3-methylflavone-8-carboxylic acid +  
3-Methyluric acid 
3-pyridinemethanol  
3-sulfopropanediol +  
4-(2,6-dioxo-1-propyl-3,7-dihydropurin-8-yl)benzenesulfonic acid 
4-[(1,3-dimethyl-2,6-dioxo-7H-purin-8-yl)methylamino]benzoic acid 
4-[2-[2-[3-methyl-2,6-dioxo-8-(1-piperidinyl)-7-purinyl]ethylidene]hydrazinyl]benzoic acid 
4-[7-(2-methoxyethyl)-2,6-dioxo-3-(phenylmethyl)-8-purinyl]benzonitrile 
4-[[7-[(4-fluorophenyl)methyl]-1,3-dimethyl-2,6-dioxo-8-purinyl]methyl]-1-piperazinecarboxylic acid ethyl ester 
5-hydroxyisouric acid +  
5-hydroxyisouric acid anion 
5beta-dihydrotestosterone 
6,8-Dihydroxypurine 
6-(9'-Purine-6',8'-diolyl)-2beta-suberosanone 
6-Thiourate  
7,8-dihydro-8-oxoguanine  
7-(2-chloroethyl)-1,3-dimethylpurine-2,6-dione 
7-(2-ethoxyethyl)-3-methyl-8-(1-pyrrolidinyl)purine-2,6-dione 
7-(2-hydroxyethyl)-1,3-dimethylpurine-2,6-dione 
7-(2-methoxyethyl)-3-methyl-8-(phenylthio)purine-2,6-dione 
7-(3-chlorobut-2-enyl)-1,3-dimethyl-8-(2-phenylethylamino)purine-2,6-dione 
7-(3-methoxypropyl)-3-(phenylmethyl)-8-(3-thiophenyl)purine-2,6-dione 
7-[(2-chloro-6-fluorophenyl)methyl]-1,3-dimethyl-8-(1-piperidinylmethyl)purine-2,6-dione 
7-[(2-chloro-6-fluorophenyl)methyl]-1,3-dimethyl-8-[(3-methyl-1-piperidinyl)methyl]purine-2,6-dione 
7-[(3-bromophenyl)methyl]-1,3-dimethyl-8-(2-methylpropylamino)purine-2,6-dione 
7-[(3-bromophenyl)methyl]-1,3-dimethyl-8-(3-pyridinylmethylamino)purine-2,6-dione 
7-[(4-fluorophenyl)methyl]-1,3-dimethyl-8-[(2-oxo-2-thiophen-2-ylethyl)thio]purine-2,6-dione 
7-[2-(1,3-benzothiazol-2-ylthio)ethyl]-1,3-dimethyl-8-(3-methyl-1-piperidinyl)purine-2,6-dione 
7-[2-hydroxy-3-(2-methylphenoxy)propyl]-3-methyl-8-(propan-2-ylthio)purine-2,6-dione 
7-[2-hydroxy-3-(4-methoxyphenoxy)propyl]-1,3-dimethyl-8-(1-piperidinyl)purine-2,6-dione 
7-[2-hydroxy-3-[2-hydroxyethyl(methyl)amino]propyl]-1,3-dimethylpurine-2,6-dione 
7-\{2-hydroxy-3-[(naphthalen-1-yl)oxy]propyl\}-3-methyl-8-(morpholin-4-yl)-3,7-dihydropurine-2,6-dione 
7-benzyl-1,3-dimethyl-8-piperazin-1-yl-3,7-dihydropurine-2,6-dione 
7-but-2-enyl-3-methyl-8-(3-phenylpropylthio)purine-2,6-dione 
7-but-2-enyl-3-methyl-8-(phenylmethylthio)purine-2,6-dione 
7-epiclusianone 
7-Methyluric acid 
7-methylxanthine 
8-(1,3-benzothiazol-2-ylthio)-3-methyl-7-pentylpurine-2,6-dione 
8-(2,5-dimethylphenoxy)-1,3-dimethyl-7-prop-2-enylpurine-2,6-dione 
8-(3-ethoxypropylamino)-1,3-dimethyl-7H-purine-2,6-dione 
8-(4-methoxyphenyl)-7-methyl-3-(phenylmethyl)purine-2,6-dione 
8-(butan-2-ylthio)-7-[(4-chlorophenyl)methyl]-3-methylpurine-2,6-dione 
8-(methoxymethyl)-1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione 
8-[(1-ethyl-3-piperidinyl)thio]-1,3-dimethyl-6-sulfanylidene-7H-purin-2-one 
8-[(2-fluoroanilino)hydrazinylidene]-1,3-dimethylpurine-2,6-dione 
8-[2-(2-bromo-3-phenylprop-2-enylidene)hydrazinyl]-7-(2-hydroxyethyl)-3-methylpurine-2,6-dione 
8-[[4-[2-furanyl(oxo)methyl]-1-piperazinyl]methyl]-1,3-dimethyl-7-[(2-methylphenyl)methyl]purine-2,6-dione 
8-[[4-[2-furanyl(oxo)methyl]-1-piperazinyl]methyl]-1,3-dimethyl-7-propylpurine-2,6-dione 
8-anilino-1,3-dimethyl-7H-purine-2,6-dione 
8-bromo-3',5'-cyclic GMP  
8-cyclopentyl-1,3-dimethyl-7H-purine-2,6-dione 
8-hydroxy-7-methylguanine 
8-oxoadenine 
8-oxoguanine 
8-phenyl-1,3-dipropyl-7H-purine-2,6-dione 
9-Methylxanthine 
acetylcholine +   
aclidinium +  
aclidinium bromide 
ACT-333679 +  
acyclovir  
adenosine +   
adenosine phosphodiesterase inhibitor +   
ajmalicine  
albuterol +   
alcuronium +   
alprazolam  
aminoethyl nitrate +  
aminophylline  
amlodipine +   
amlodipine benzenesulfonate +  
amphetamine +   
amrinone  
anandamide +   
Anoro Ellipta 
antispasmodic drug +   
arformoterol +  
arformoterol fumarate +   
Arg-Phe 
atracurium +   
atracurium besylate +  
atropine +   
avanafil 
azelastine +   
azelastine hydrochloride 
azumolene 
baclofen  
bambuterol +   
bambuterol hydrochloride +  
bamethan +  
bamifylline 
BAY 41-2272 
benzyl nicotinate 
bepridil +   
beraprost  
beraprost sodium 
beta-erythroidine +   
betahistine  
Bevespi Aerosphere 
bitolterol +  
bitolterol mesylate +  
bradykinin +  
Breo Ellipta 
bucladesine  
budesonide  
cafaminol 
cafedrine 
caffeine +   
carbon dioxide  
carbon monoxide  
carisoprodol +   
carpronium chloride 
carvedilol  
CGP-42112A  
chlormezanone +  
chloropropane-1,2-diol +   
chlorphenesin +   
chlorphenesin carbamate  
chlorzoxazone  
cilostazol  
cinaciguat  
cisatracurium +   
cisatracurium besylate 
clenbuterol +   
clenbuterol hydrochloride +  
clonixin 
clonixin lysine salt 
clorprenaline  
colforsin daropate 
colforsin daropate hydrochloride  
colterol 
convallatoxin 
cyclandelate 
cyclobenzaprine +   
cyclobenzaprine hydrochloride 
dantrolene  
dantrolene sodium hemiheptahydrate 
ddhGMP 
ddhGTP 
decamethonium  
devapamil 
diallyl trisulfide  
diazoxide  
dihydroergocristine +  
dihydroergocristine mesylate +  
diltiazem  
diltiazem hydrochloride 
diltiazem(1+) +  
dimethazan 
dinitrogen oxide  
diphemanil methylsulfate 
dipyridamole  
dotarizine 
doxacurium +  
doxacurium chloride 
doxazosin +   
doxofylline 
DPCPX  
dyphylline +  
An oxopurine that is theophylline bearing a 2,3-dihydroxypropyl group at the 7 position. It has broncho- and vasodilator properties, and is used in the treatment of asthma, cardiac dyspnea, and bronchitis. It is also an ingredient in preparations that have been promoted for coughs.
EC 3.1.4.11 (phosphoinositide phospholipase C) inhibitor +   
EC 3.1.4.12 (sphingomyelin phosphodiesterase) inhibitor +   
EC 3.1.4.17 (3',5'-cyclic-nucleotide phosphodiesterase) inhibitor +   
EC 3.1.4.35 (3',5'-cyclic-GMP phosphodiesterase) inhibitor +   
EC 3.1.4.53 (3',5'-cyclic-AMP phosphodiesterase) inhibitor +   
efonidipine 
EHNA +  
enprofylline +  
entecavir (anhydrous) +  
eperisone 
ergoloid mesylate 
erythrityl tetranitrate 
etamiphylline 
etofylline clofibrate 
etofylline nicotinate 
eupatorin  
felodipine  
fenetylline 
fenoldopam  
fenoterol +   
fenoterol hydrobromide 
fluticasone propionate 
formoterol 
formoterol fumarate +   
forskoditerpenoside C 
forskoditerpenoside D 
forskoditerpenoside E 
Furafylline  
gallamine 
ganciclovir +   
graminone B 
guanine +   
hydralazine +   
hydralazine hydrochloride 
hydrogen sulfide +   
hypoxanthine +   
hypoxanthine 3-N-oxide +  
Ile(5)-angiotensin II (1-7) 
iloprost  
indacaterol 
indacaterol maleate +  
ipratropium bromide +  
ipratropium bromide hydrate 
isoamyl nitrite 
isoguanine 
isoprenaline  
isosorbide dinitrate  
isosorbide mononitrate  
istradefylline  
itramin tosilate 
JWH-133 
khellin 
levosimendan 
lificiguat 
LSM-1748 
methacholine +   
methocarbamol 
methoxyphenamine +  
methyl brevifolincarboxylate 
methylguanine +   
methylhypoxanthine +  
midazolam +   
midazolam hydrochloride 
Migrenin (TN) 
milrinone  
minoxidil  
mirodenafil 
monothioglycerol +   
morphine +   
N-(4-cyanophenyl)-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide 
N-arachidonoyl-L-serine 
N-ethyl-5'-carboxamidoadenosine  
n-pentyl nitrite 
nebivolol  
nebivolol hydrochloride +  
nelociguat 
nicorandil  
nicotinic acid +   
nifedipine  
nimodipine  
nisoldipine  
nitrendipine  
nitric oxide  
nitroflurbiprofen  
nitroglycerin  
nitroproston 
norverapamil  
O6-CYCLOHEXYLMETHOXY-2-(4'-SULPHAMOYLANILINO) PURINE 
olodaterol  
olodaterol hydrochloride +  
orciprenaline  
orphenadrine +   
orphenadrine citrate 
orphenadrine hydrochloride 
oxybutynin +   
oxytocin +   
pancuronium +   
pancuronium bromide 
papaverine  
partial prostacyclin agonist +  
PD 0325901  
pentaerythritol tetranitrate  
pentamethonium +  
pentamethonium bromide 
pentifylline 
Pentoxifylline  
petasin 
phentetramine 
phentolamine  
piclamilast  
pimefylline 
pimobendan  
pindolol +   
pinocembrin +   
praliciguat 
pridinol  
propane-1,2-diol +   
Propentofylline 
propranolol +   
prostaglandin E1 +   
protheobromine 
Proxyphylline 
pseudoephedrine 
quinaprilat  
quinine +   
quinine(1+) +   
remikiren 
reproterol 
ritropirronium bromide +  
Ro 320-1195 +  
rocuronium +   
rocuronium bromide 
rolipram +   
S-nitroso-L-cysteine +   
S-nitroso-N-acetyl-D-penicillamine  
S-nitrosoglutathione  
salmeterol 
selexipag 
sildenafil +   
sildenafil citrate  
sodium 8-bromo-3',5'-cyclic GMP 
sodium nitroprusside +  
sodium nitroprusside dihydrate 
spathulenol  
sphingosine 1-phosphate  
Stiolto Respimat 
succinylcholine +   
succinylcholine chloride (anhydrous) +  
succinylcholine chloride dihydrate 
sulmazole 
tadalafil  
terbutaline +   
tetramethylpyrazine  
theobromine  
theodrenaline 
theophylline +   
Theophylline sodium acetate 
tiotropium 
tiotropium bromide  
tiotropium bromide hydrate +  
tizanidine  
tolazoline  
tolterodine +   
treprostinil +   
triacsin C  
trimethaphan +   
troglitazone  
tubocurarine  
urate(2-) +  
uric acid +   
Utibron Neohaler 
vardenafil 
vecuronium +   
vecuronium bromide  
verapamil  
vericiguat 
vilanterol +  
vilanterol trifenate +  
vincamine  
visnagin 
xanthine +   
xylazine  
xylazine hydrochloride 
zardaverine  
zofenopril 
zofenopril calcium 
zofenoprilat 
zofenoprilat arginine 

Synonyms
Related Synonyms: (1,2-dihydroxy-3-propyl)thiophyllin ;   1,3-dimethyl-7-(2,3-dihydroxypropyl)xanthine ;   7-(2,3-dihydroxypropyl)-1,3-dimethylxanthine ;   7-(2,3-dihydroxypropyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione ;   7-(2,3-dihydroxypropyl)theophylline ;   7-(beta,gamma-dihydroxypropyl)theophylline ;   Dihydroxypropyl theopylin ;   Diprophylline ;   Formula=C10H14N4O4 ;   InChI=1S/C10H14N4O4/c1-12-8-7(9(17)13(2)10(12)18)14(5-11-8)3-6(16)4-15/h5-6,15-16H,3-4H2,1-2H3 ;   InChIKey=KSCFJBIXMNOVSH-UHFFFAOYSA-N ;   SMILES=Cn1c2ncn(CC(O)CO)c2c(=O)n(C)c1=O ;   diprofilina ;   diprophyllinum
Alternate IDs: CHEBI:681819
Xrefs: Beilstein:284563 ;   CAS:479-18-5 ;   DrugBank:DB00651 ;   Drug_Central:976 ;   HMDB:HMDB0014789 ;   KEGG:C07819 ;   KEGG:D00691 ;   KNApSAcK:C00030143 ;   LINCS:LSM-4299 ;   PMID:28166217 ;   PMID:2886621 ;   PMID:3361424 ;   Patent:US2575344 ;   Reaxys:284563 ;   Wikipedia:Dyphylline

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