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Ontology Browser

Term:
EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor (CHEBI:35664)
Annotations: Rat: (987) Mouse: (1000) Human: (993) Chinchilla: (0) Bonobo: (0) Dog: (3) Squirrel: (0) Pig: (6)
Parent Terms Term With Siblings Child Terms
EC 1.1.1.1 (alcohol dehydrogenase) inhibitor +   
EC 1.1.1.141 [15-hydroxyprostaglandin dehydrogenase (NAD(+))] inhibitor +   
EC 1.1.1.146 (11beta-hydroxysteroid dehydrogenase) inhibitor +   
EC 1.1.1.153 [sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)] inhibitor +   
EC 1.1.1.159 (7alpha-hydroxysteroid dehydrogenase) inhibitor +  
EC 1.1.1.170 [3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)] inhibitor +  
EC 1.1.1.184 [carbonyl reductase (NADPH)] inhibitor +   
EC 1.1.1.188 (prostaglandin-F synthase) inhibitor +   
EC 1.1.1.189 (prostaglandin-E2 9-reductase) inhibitor +   
EC 1.1.1.205 (IMP dehydrogenase) inhibitor +   
EC 1.1.1.21 (aldehyde reductase) inhibitor +   
EC 1.1.1.210 [3beta(or 20alpha)-hydroxysteroid dehydrogenase] inhibitor +   
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor +   
EC 1.1.1.267 (1-deoxy-D-xylulose-5-phosphate reductoisomerase) inhibitor +  
EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor +   
Any EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor that inhibits HMG-CoA reductases. Hydroxymethylglutaryl-CoA reductase inhibitors have been shown to lower directly cholesterol synthesis. The Enzyme Commission designation is EC 1.1.1.34 for the NADPH-dependent enzyme and EC 1.1.1.88 for an NADH-dependent enzyme.
EC 1.1.1.37 (malate dehydrogenase) inhibitor +  
EC 1.1.1.42 (isocitrate dehydrogenase) inhibitor +  
EC 1.1.1.44 (NADP(+)-dependent decarboxylating phosphogluconate dehydrogenase) inhibitor +   

Synonyms
Related Synonyms: HMG-CoA reductase inhibitor ;   HMG-CoA reductase inhibitors ;   hydroxymethylglutaryl-CoA reductase inhibitor ;   hydroxymethylglutaryl-CoA reductase inhibitors
Xrefs: PMID:1464741 ;   PMID:15531285 ;   PMID:20467214 ;   Wikipedia:HMG-CoA_reductase

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