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Term:
Parent Terms Term With Siblings Child Terms
(6R)-7-[(2-amino-1-oxo-2-phenylethyl)amino]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
(6R,7R)-3-(acetyloxymethyl)-7-[[2-(2-amino-4-thiazolyl)-2-methoxyimino-1-oxoethyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
(6R,7R)-3-(carbamoyloxymethyl)-7-[[2-(2-furanyl)-2-methoxyimino-1-oxoethyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
(6R,7R)-3-[(4-carbamoyl-1-pyridin-1-iumyl)methyl]-8-oxo-7-[(1-oxo-2-thiophen-2-ylethyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 
(6R,7R)-3-[(4-carbamoyl-1-pyridin-1-iumyl)methyl]-8-oxo-7-[(1-oxo-2-thiophen-2-ylethyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
(6R,7R)-7-[[(2R)-2-amino-2-(4-hydroxyphenyl)-1-oxoethyl]amino]-8-oxo-3-[(2H-triazol-4-ylthio)methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid propane-1,2-diol 
(6R,7R)-7-[[2-(2-amino-4-thiazolyl)-2-(2-carboxypropan-2-yloxyimino)-1-oxoethyl]amino]-8-oxo-3-(1-pyridin-1-iumylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
(6R,7R)-7-[[2-(2-amino-4-thiazolyl)-2-(carboxymethoxyimino)-1-oxoethyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
(6R,7R)-7-[[2-(2-amino-4-thiazolyl)-2-hydroxyimino-1-oxoethyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
(6R,7R)-7-[[2-(2-amino-4-thiazolyl)-2-methoxyimino-1-oxoethyl]amino]-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 1-[oxo(propan-2-yloxy)methoxy]ethyl ester 
(6R,7R)-7-[[2-amino-2-(4-hydroxyphenyl)-1-oxoethyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
(6R,7S)-3-(acetyloxymethyl)-8-oxo-7-[(1-oxo-2-thiophen-2-ylethyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
(6R,7S)-3-[(4-carbamoyl-1-pyridin-1-iumyl)methyl]-8-oxo-7-[[(2R)-1-oxo-2-phenyl-2-sulfoethyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
(6R,7S)-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[[1-oxo-2-(1-tetrazolyl)ethyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
(6R,7S)-7-[[2-(2-amino-4-thiazolyl)-1-oxoethyl]amino]-3-[[[1-[2-(dimethylamino)ethyl]-5-tetrazolyl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
(6R,7S)-7-[[2-[2-(aminomethyl)phenyl]-1-oxoethyl]amino]-3-[[[1-(carboxymethyl)-5-tetrazolyl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
(7R)-7-(4-carboxybutanamido)cephalosporanic acid 
(7R)-7-(5-carboxy-5-oxopentanamido)cephalosporanic acid 
(7R)-7-[[2-(2-amino-1,3-thiazol-4-yl)-2-(2-carboxypropan-2-yloxyimino)acetyl]amino]-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
(R)-iclaprim +  
(R)-temafloxacin +  
(S)-iclaprim +  
(S)-temafloxacin +  
21-deoxyconcanamycin A 
21-phosphorifampicin 
3-(acetyloxymethyl)-7-[[2-(2-amino-4-thiazolyl)-2-methoxyimino-1-oxoethyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
3-(acetyloxymethyl)-7-[[3-(4-chloro-3,5-dimethyl-1-pyrazolyl)-2-methyl-1-oxopropyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
3-(carbamoyloxymethyl)-7-[[2-(2-furanyl)-2-methoxyimino-1-oxoethyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
3-(carbamoyloxymethyl)cephalosporin +   
3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[[1-oxo-2-(1-tetrazolyl)ethyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
3-aza-A-homocholest-4a-en-4-one 
3-hydroxymethylcephalosporin +  
4-\{((R)-2-Carboxy-3-methoxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-en-7-ylcarbamoyl)-[(Z)-methoxyimino]-methyl\}-thiazol-2-yl-ammonium +  
6'-O-acetylpaeoniflorin 
6-bromoharmine 
7-[[2-(4-chloro-3,5-dimethyl-1-pyrazolyl)-1-oxoethyl]amino]-3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
7-[[2-(4-chloro-3-methyl-1-pyrazolyl)-1-oxopropyl]amino]-3-[[(1-methyl-5-tetrazolyl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
7-[[2-[5-cyclopropyl-3-(difluoromethyl)-1-pyrazolyl]-1-oxoethyl]amino]-3-[[(1-methyl-5-tetrazolyl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
7-[[2-amino-2-(4-hydroxyphenyl)-1-oxoethyl]amino]-8-oxo-3-prop-1-enyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
7beta-aminodeacetoxycephalosporanic acid 
amikacin  
amikacin disulfate 
amoxicillin +   
amoxicillin trihydrate +   
ampicillin +   
anidulafungin 
antimycobacterial drug +   
antitreponemal drug +  
apramycin 
arasertaconazole +   
arbekacin +  
artemether  
artesunate  
Augmentin  
avibactam 
avibactam sodium +  
Avycaz 
azetidin-2-one 
azithromycin +   
azlocillin 
aztreonam +   
benzyl isothiocyanate  
benzylpenicillin +   
biapenem 
brodimoprim 
carbapenem MM22383 
carbenicillin +  
carumonam 
caspofungin +   
cefacetrile 
cefaclor  
cefadroxil +   
cefaloglycin 
cefaloridine  
cefalotin +   
cefamandole +  
cefamandole nafate 
cefamandole sodium 
cefathiamidine 
cefatrizine 
cefazedone 
cefazolin  
Cefazolin sodium hydrate 
cefbuperazone 
cefcapene 
cefclidin 
cefdaloxime 
cefdinir  
cefditoren +  
cefditoren pivoxil 
cefepime  
cefepime hydrochloride 
cefepime(1+) +  
cefetamet 
cefiderocol 
cefixime  
cefluprenam 
cefmenoxime +  
cefmetazole  
cefodizime 
Cefodizime sodium 
cefonicid  
cefoperazone  
ceforanide 
cefoselis +   
cefotaxime  
cefotetan  
cefotetan disodium 
cefotiam +   
A cephalosporin with ({1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl}sulfanyl)methyl and (2-amino-1,3-thiazol-4-yl)acetamido substituents at positions 3 and 7, respectively, of the cephem skeleton. A third generation beta-lactam cephalosporin antibiotic, it is active against a broad spectrum of both Gram positive and Gram negative bacteria.
cefotiam dihydrochloride 
cefotiam hexetil dihydrochloride 
cefoxitin  
cefozopran 
cefpiramide 
cefpirome +  
cefpodoxime +   
cefpodoxime proxetil 
cefprozil 
cefroxadine 
cefsulodin 
ceftaroline +  
ceftaroline fosamil +  
ceftaroline fosamil acetate +  
ceftaroline fosamil acetate monohydrate 
ceftazidime +   
cefteram 
ceftezole 
ceftibuten +   
ceftibuten dihydrate 
ceftiolene 
ceftizoxime  
ceftobiprole 
ceftobiprole medocaril 
ceftolozane 
ceftriaxone  
Ceftriaxone disodium salt hemiheptahydrate 
Cefuroxime axetil 
cefuroxime pivoxetil 
cefuzonam 
cephalexin +   
cephalexin monohydrate 
cephalosporanic acid +   
cephalosporin C +   
cephapirin 
cephapirin sodium 
cephradine  
cethromycin 
chloramphenicol +   
chlorphenesin +   
chlorquinaldol 
chlortetracycline  
cinoxacin  
ciprofloxacin +   
ciprofloxacin dihydrochloride 
ciprofloxacin hydrochloride (anhydrous) +  
ciprofloxacin hydrochloride hydrate 
clarithromycin  
clavulanic acid 
clindamycin +   
clometocillin 
clomocycline 
cloxacillin  
co-trimoxazole  
cyclacillin 
dalbavancin 
daptomycin 
deacetoxycephalosporin C 
demeclocycline +   
demeclocycline hydrochloride 
dicloxacillin  
difloxacin 
dihydroergotamine +   
doxycycline +   
doxycycline hyclate 
doxycycline monohydrate 
emodepside 
enoxacin  
eprinomectin component B1a +   
eprinomectin component B1b +   
ertapenem 
ertapenem sodium 
fenticonazole 
fenticonazole nitrate 
fidaxomicin 
finafloxacin 
fleroxacin 
flomoxef 
flucloxacillin +   
flurithromycin 
framycetin +   
fumagillin +   
furagin 
furaltadone 
furazolidone  
garenoxacin 
gemifloxacin +  
GM 193663 
hetacillin 
hexamethylenetetramine +  
humulone 
iclaprim 
imipenem +   
isoconazole  
isoconazole nitrate 
josamycin  
kanamycin A sulfate 
KT 5720  
leucascandrolide A congener 
levofloxacin  
linezolid  
loracarbef 
LSM-5500 
LSM-5644 
LSM-5686 
lymecycline 
malachite green cation +   
marbofloxacin 
mecillinam +  
meropenem +   
meropenem trihydrate 
methacycline 
methicillin +  
metronidazole +   
metronidazole benzoate 
metronidazole hydrochloride 
mezlocillin 
minocycline +   
moxalactam 
moxifloxacin  
moxifloxacin hydrochloride 
mupirocin 
N(2)-methylharmine 
N-butylharmine 
N-ethylharmine 
nadifloxacin +  
nafcillin  
nalidixic acid  
nifurtoinol 
nitrofurantoin  
nitrofurazone  
norfloxacin  
O-(chloroacetylcarbamoyl)fumagillol  
O-formylcefamandole 
ofloxacin +   
oritavancin +  
oritavancin bisphosphate 
ornidazole  
oxacillin +   
oxolinic acid 
oxycodone  
oxytetracycline  
paromomycin +   
paromomycin sulfate 
pefloxacin +  
pefloxacin mesylate 
penamecillin 
pipemidic acid  
piperacillin +   
piromidic acid 
pivmecillinam +  
potassium clavulanate +   
pristinamycin 
pristinamycin IA +  
pristinamycin IIA +  
prontosil  
retaspimycin 
ribostamycin +  
ribostamycin sulfate 
ridaforolimus 
rifampicin +   
rifaximin  
ristocetin 
rolitetracycline 
rosoxacin 
roxarsone  
roxithromycin +   
rubitecan  
salicylhydroxamic acid  
sertaconazole  
sertaconazole nitrate 
SH-11037 
silver(1+) sulfadiazinate 
sirolimus +   
spectinomycin 
spectinomycin dihydrochloride 
spectinomycin hydrochloride hydrate 
spiramycin I 
spiramycin II 
statin (semi-synthetic) +   
streptomycin +   
sulfacetamide 
sulfachloropyridazine 
sulfadoxine 
sulfamazone 
sulfamethazine  
sulfaperin 
sulfaphenazole  
sulfathiourea 
sulfisoxazole +   
sulfisoxazole diolamine 
teicoplanin  
telavancin +  
telavancin hydrochloride 
temafloxacin 
tetracycline +   
tetracycline zwitterion 
thiostrepton  
thiram  
tiamulin  
ticarcillin 
tigecycline +   
tinidazole  
trimethoprim +   
troleandomycin  
trovafloxacin  
trovafloxacin mesylate 
TX-1875 
vancomycin +   
vinflunine 
virginiamycin 
virginiamycin S1 +  
xibornol 

Synonyms
Exact Synonyms: (6R,7R)-7-{[(2-amino-1,3-thiazol-4-yl)acetyl]amino}-3-[({1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl}sulfanyl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid ;   7beta-(2-amino-1,3-thiazol-4-yl)acetamido-3-[({1-[2-(dimethylamino)ethyl]-1H-tetrazol-5-yl}sulfanyl)methyl]-3,4-didehydrocepham-4-carboxylic acid
Related Synonyms: (6R,7R)-7-[2-(2-Amino-thiazol-4-yl)-acetylamino]-3-[1-(2-dimethylamino-ethyl)-1H-tetrazol-5-ylsulfanylmethyl]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid ;   CTM ;   Formula=C18H23N9O4S3 ;   InChI=1S/C18H23N9O4S3/c1-25(2)3-4-26-18(22-23-24-26)34-7-9-6-32-15-12(14(29)27(15)13(9)16(30)31)21-11(28)5-10-8-33-17(19)20-10/h8,12,15H,3-7H2,1-2H3,(H2,19,20)(H,21,28)(H,30,31)/t12-,15-/m1/s1 ;   InChIKey=QYQDKDWGWDOFFU-IUODEOHRSA-N ;   SMILES=[H][C@]12SCC(CSc3nnnn3CCN(C)C)=C(N1C(=O)[C@@]2([H])NC(=O)Cc1csc(N)n1)C(O)=O ;   cefotiamum
Xrefs: CAS:61622-34-2 "ChemIDplus" ;   DrugBank:DB00229 ;   Drug_Central:548 "DrugCentral" ;   KEGG:D07648 ;   LINCS:LSM-2022
Xref Mesh: MESH:D015310
Xrefs: PMID:28543395 "Europe PMC" ;   PMID:6341590 "ChEMBL" ;   Patent:DE2458695 ;   Patent:US4080498 ;   Wikipedia:Cefotiam

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.