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Term:
Parent Terms Term With Siblings Child Terms
adenine +   
oxopurine +     
purine nucleobase +     
(3S,4R,5R)-5-(adenin-9-yl)-4-hydroxytetrahydrofuran-3-yl dihydrogen phosphate 
1',3'-dimethylspiro[1H-indole-3,8'-7,9-dihydropurine]-2,2',6'-trione 
1,3,7-trimethyl-5-hydroxyisouric acid 
1,3,7-trimethyl-8-(phenylmethyl)purine-2,6-dione 
1,3,7-trimethylisoguanine 
1,3,7-trimethyluric acid  
1,3-dibutyl-7-(2-oxopropyl)purine-2,6-dione 
1,3-dimethyl-7-(5-oxohexyl)purine-2,6-dione 
1,3-dimethyl-7-(phenylmethyl)-8-[2-(thiophen-2-ylmethylidene)hydrazinyl]purine-2,6-dione 
1,3-dimethyl-8-(3-methyl-1-piperidinyl)-7-[2-[(5-methyl-1,3,4-thiadiazol-2-yl)thio]ethyl]purine-2,6-dione 
1,3-dimethyl-8-[2-(1-pyrrolidinyl)ethylthio]-6-sulfanylidene-7H-purin-2-one 
1,3-dimethyl-8-[[methyl-(phenylmethyl)amino]methyl]-7-(2-methylpropyl)purine-2,6-dione 
1,3-dimethyl-8-[methyl-(phenylmethyl)amino]-7-[2-(2-pyrimidinylthio)ethyl]purine-2,6-dione 
1,3-dimethyluric acid 
1,4-butanediammonium 
1,7-dimethyluric acid  
1,N(2)-ethenoguanine 
1-methyl-3-propyl-7H-xanthine 
1-methyluracil 
1-methyluric acid  
1H-imidazo[2,1-i]purine  
2',3'-secoguanosine 
2'-deoxyadenosine 5'-monophosphate +  
2'-deoxyadenosine 5'-monophosphate(2-) +  
2-(1,3-dimethyl-2,6-dioxo-7-purinyl)-N'-[2-(2-ethoxyphenoxy)-1-oxoethyl]acetohydrazide 
2-(1,3-dimethyl-2,6-dioxo-7-purinyl)-N-(phenylmethyl)-N-(2-pyridinyl)acetamide 
2-(1,3-dimethyl-2,6-dioxo-7-purinyl)-N-[3-[(4-methoxyphenyl)sulfamoyl]-4-methylphenyl]acetamide 
2-(1,3-dimethyl-2,6-dioxo-7-purinyl)acetic acid 
2-(\{8-[(3R)-3-aminopiperidin-1-yl]-1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl\}methyl)benzonitrile 
2-[(1,3-dimethyl-2,6-dioxo-7-propyl-8-purinyl)thio]-N-(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)acetamide 
2-[(7-ethyl-1,3-dimethyl-2,6-dioxo-8-purinyl)thio]-N-(6-methyl-2-pyridinyl)acetamide 
2-[[3-methyl-7-(3-methylbutyl)-2,6-dioxo-8-purinyl]thio]propanoic acid methyl ester 
2-[[7-(3-chlorobut-2-enyl)-3-methyl-2,6-dioxo-8-purinyl]thio]butanoic acid ethyl ester 
2-amino-6-hydroxyaminopurine 
2-aminopurine +   
2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine 
2-deoxy-D-ribofuranose 1-phosphate +   
2-furancarboxylic acid [4-[[[1,3-dimethyl-2,6-dioxo-7-(phenylmethyl)-8-purinyl]hydrazinylidene]methyl]phenyl] ester 
2-oxoglutarate(1-) 
2-oxoglutaric acid +  
3,5-dimethyl-4-isoxazolecarboxylic acid (3-butyl-2,6-dioxo-7-propyl-8-purinyl)methyl ester 
3,7-dimethyl-1-(phenylmethyl)-8-[(phenylmethyl)amino]purine-2,6-dione 
3,7-dimethylisoguanine 
3,7-dimethyluric acid 
3-butyl-8-(2-fluorophenyl)-7-(phenylmethyl)purine-2,6-dione 
3-isobutyl-1-methylxanthine +   
3-methyl-7-(2-phenylethyl)-8-(propylamino)purine-2,6-dione 
3-methyl-7-(phenylmethyl)-8-(propan-2-ylthio)purine-2,6-dione 
3-methyl-7-[(4-methylphenyl)methyl]-8-[2-(1-piperidinyl)ethylthio]purine-2,6-dione 
3-methyl-7-pentyl-8-(2-phenylethylthio)purine-2,6-dione 
3-methyluracil 
3-phosphoglyceric acid +   
3-phosphonato-D-glycerate(3-) 
4-(2,6-dioxo-1-propyl-3,7-dihydropurin-8-yl)benzenesulfonic acid 
4-[(1,3-dimethyl-2,6-dioxo-7H-purin-8-yl)methylamino]benzoic acid 
4-[2-[2-[3-methyl-2,6-dioxo-8-(1-piperidinyl)-7-purinyl]ethylidene]hydrazinyl]benzoic acid 
4-[7-(2-methoxyethyl)-2,6-dioxo-3-(phenylmethyl)-8-purinyl]benzonitrile 
4-[[7-[(4-fluorophenyl)methyl]-1,3-dimethyl-2,6-dioxo-8-purinyl]methyl]-1-piperazinecarboxylic acid ethyl ester 
5,6-dihydroxyuracil 
5-(4,5-dihydroxypentyl)uracil 
5-(hydroxymethyl)cytosine +   
5-bromouracil 
5-carboxycytosine 
5-fluoroorotic acid 
5-fluorouracil  
5-formylcytosine 
5-formyluracil 
5-hydroxyisouric acid +  
5-hydroxyisouric acid anion 
6-(9'-Purine-6',8'-diolyl)-2beta-suberosanone 
6-[(1,2-dideoxy-D-ribityl)amino]-5-[(E)-(2-oxopropylidene)amino]uracil 
6-[(1,3-dideoxy-D-ribityl)amino]-5-[(E)-(2-oxopropylidene)amino]uracil 
6-[(1,4-dideoxy-D-ribityl)amino]-5-[(E)-(2-oxopropylidene)amino]uracil 
6-[(1,5-dideoxy-D-ribityl)amino]-5-[(E)-(2-oxopropylidene)amino]uracil 
6-[(1-deoxy-D-ribityl)methyl]-5-[(1E)-3-oxobut-1-en-1-yl]uracil 
6-[(2-hydroxyethyl)amino]-5-[(E)-(2-oxopropylidene)amino]uracil 
6-[(3-hydroxypropyl)amino]-5-[(E)-(2-oxopropylidene)amino]uracil 
6-[(4-hydroxybutyl)amino]-5-[(E)-(2-oxopropylidene)amino]uracil 
6-[(5-hydroxypentyl)amino]-5-[(E)-(2-oxopropylidene)amino]uracil 
6-alkylaminopurine +  
6-azathymine +  
6-azauracil 
6-hydroxymethyladenine 
6-isopentenylaminopurine +   
6-methyl-5-[(1E)-3-oxobut-1-en-1-yl]uracil 
6-phospho-D-gluconic acid 
6-phosphonatooxy-D-gluconate 
6-Thiourate  
7,8-dihydro-8-oxoguanine  
7-(2-chloroethyl)-1,3-dimethylpurine-2,6-dione 
7-(2-ethoxyethyl)-3-methyl-8-(1-pyrrolidinyl)purine-2,6-dione 
7-(2-hydroxyethyl)-1,3-dimethylpurine-2,6-dione 
7-(2-methoxyethyl)-3-methyl-8-(phenylthio)purine-2,6-dione 
7-(3-chlorobut-2-enyl)-1,3-dimethyl-8-(2-phenylethylamino)purine-2,6-dione 
7-(3-methoxypropyl)-3-(phenylmethyl)-8-(3-thiophenyl)purine-2,6-dione 
7-[(2-chloro-6-fluorophenyl)methyl]-1,3-dimethyl-8-(1-piperidinylmethyl)purine-2,6-dione 
7-[(2-chloro-6-fluorophenyl)methyl]-1,3-dimethyl-8-[(3-methyl-1-piperidinyl)methyl]purine-2,6-dione 
7-[(3-bromophenyl)methyl]-1,3-dimethyl-8-(2-methylpropylamino)purine-2,6-dione 
7-[(3-bromophenyl)methyl]-1,3-dimethyl-8-(3-pyridinylmethylamino)purine-2,6-dione 
7-[(4-fluorophenyl)methyl]-1,3-dimethyl-8-[(2-oxo-2-thiophen-2-ylethyl)thio]purine-2,6-dione 
7-[2-(1,3-benzothiazol-2-ylthio)ethyl]-1,3-dimethyl-8-(3-methyl-1-piperidinyl)purine-2,6-dione 
7-[2-hydroxy-3-(2-methylphenoxy)propyl]-3-methyl-8-(propan-2-ylthio)purine-2,6-dione 
7-[2-hydroxy-3-(4-methoxyphenoxy)propyl]-1,3-dimethyl-8-(1-piperidinyl)purine-2,6-dione 
7-[2-hydroxy-3-[2-hydroxyethyl(methyl)amino]propyl]-1,3-dimethylpurine-2,6-dione 
7-\{2-hydroxy-3-[(naphthalen-1-yl)oxy]propyl\}-3-methyl-8-(morpholin-4-yl)-3,7-dihydropurine-2,6-dione 
7-benzyl-1,3-dimethyl-8-piperazin-1-yl-3,7-dihydropurine-2,6-dione 
7-but-2-enyl-3-methyl-8-(3-phenylpropylthio)purine-2,6-dione 
7-but-2-enyl-3-methyl-8-(phenylmethylthio)purine-2,6-dione 
7-Methyluric acid 
7-methylxanthine 
8-(1,3-benzothiazol-2-ylthio)-3-methyl-7-pentylpurine-2,6-dione 
8-(2,5-dimethylphenoxy)-1,3-dimethyl-7-prop-2-enylpurine-2,6-dione 
8-(2-chloro-3,4,5-trimethoxybenzyl)-2-fluoro-9-pent-4-yn-1-yl-9H-purin-6-amine 
8-(3-ethoxypropylamino)-1,3-dimethyl-7H-purine-2,6-dione 
8-(4-methoxyphenyl)-7-methyl-3-(phenylmethyl)purine-2,6-dione 
8-(butan-2-ylthio)-7-[(4-chlorophenyl)methyl]-3-methylpurine-2,6-dione 
8-(methoxymethyl)-1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione 
8-[(1-ethyl-3-piperidinyl)thio]-1,3-dimethyl-6-sulfanylidene-7H-purin-2-one 
8-[(2-fluoroanilino)hydrazinylidene]-1,3-dimethylpurine-2,6-dione 
8-[2-(2-bromo-3-phenylprop-2-enylidene)hydrazinyl]-7-(2-hydroxyethyl)-3-methylpurine-2,6-dione 
8-[[4-[2-furanyl(oxo)methyl]-1-piperazinyl]methyl]-1,3-dimethyl-7-[(2-methylphenyl)methyl]purine-2,6-dione 
8-[[4-[2-furanyl(oxo)methyl]-1-piperazinyl]methyl]-1,3-dimethyl-7-propylpurine-2,6-dione 
8-anilino-1,3-dimethyl-7H-purine-2,6-dione 
8-azaadenine +  
8-azaguanine +   
8-azahypoxanthine 
8-cyclopentyl-1,3-dimethyl-7H-purine-2,6-dione 
8-hydroxy-7-methylguanine 
8-hydroxyadenine 
8-oxoadenine 
8-oxoguanine 
8-phenyl-1,3-dipropyl-7H-purine-2,6-dione 
9-(tetrahydrofuryl)adenine  
9-\{2,5-anhydro-4-[(phosphonooxy)methyl]-alpha-L-lyxofuranosyl\}-9H-purin-6-amine 
9-beta-D-erythrofuranosyladenine 
9-beta-D-xylofuranosyladenine 
9-Methylxanthine 
9-riburonosyladenine 
9H-purine-2,6-diamine +  
acetyl-CoA +   
acyclovir  
adefovir +   
adenin-9-yl group +  
adenine +   
adenine arabinoside +   
adenosine +   
adenosine 5'-monophosphate +   
adenosine 5'-monophosphate(1+) 
adenosine 5'-monophosphate(2-) +  
adenosines +   
ADP +   
ADP(3-) +  
alanine +   
aldehydo-D-ribose 5-phosphate(2-) 
allopurinol +   
alpha-D-glucose 1-phosphate(2-) 
alpha-D-glucose 6-phosphate(2-) 
alpha-D-mannose 6-phosphate(2-) 
alpha-L-galactose 1-phosphate(2-) 
arabinose +  
arginine +   
aspartate(1-) +  
aspartate(2-) +  
aspartic acid +   
ATP +   
ATP(3-) 
ATP(4-) +  
bamifylline 
beta-alaninate 
beta-alanine +   
beta-D-fructofuranose 6-phosphate(2-) 
beta-D-glucose 1-phosphate(2-) 
beta-D-glucose 6-phosphate(2-) +  
beta-L-galactose 1-phosphate(2-) 
cafaminol 
cafedrine 
cis-aconitic acid 
citrate(1-) +  
citrate(2-) +  
citrate(3-) +   
citric acid +   
cysteine +   
D-aspartate(1-) +  
D-cysteinate(1-) 
D-cysteinate(2-) 
D-cysteinium 
D-cysteinyl radical +  
D-erythro-isocitrate(3-) 
D-fructofuranose 1,6-bisphosphate(4-) +  
D-fructofuranose 1-phosphate(2-) +  
D-fructofuranose 6-phosphate(2-) 
D-fructose 1,6-bisphosphate +   
D-fructose 6-phosphate +  
D-galactopyranose 1-phosphate +   
D-glucopyranose 1-phosphate +   
D-glucopyranose 1-phosphate(2-) 
D-glucose 6-phosphate +   
D-mannopyranose 6-phosphate(2-) 
D-mannose 1-phosphate +  
D-mannose 6-phosphate +   
D-ribose +   
D-ribose 5-phosphate +   
D-ribulose 5-phosphate(2-) 
D-threo-isocitrate(3-) 
dGDP 
dimethazan 
doxofylline 
DPCPX  
dTMP +   
dyphylline +  
EHNA +  
enprofylline +  
entecavir (anhydrous) +  
etamiphylline 
etofylline clofibrate 
etofylline nicotinate 
fenetylline 
fructose +   
fructose 1-phosphate +  
fumarate(1-) +  
fumaric acid +   
galactose +   
ganciclovir +   
glucose +   
glutamate(1-) +   
glutamate(2-) +  
glutamic acid +   
glutamine +   
glyceraldehyde +   
glycerate +  
glyceric acid +   
glycinate +   
glycine +   
glycine betaine +   
glycine betaine hydrate 
glycinium +  
glycolaldehyde +   
glycyl radical +  
guanine +   
guanosine +   
homocysteinate +  
homocysteine +   
hypoxanthine +   
A purine nucleobase that consists of purine bearing an oxo substituent at position 6.
hypoxanthine 3-N-oxide +  
IDP 
isocitric acid +  
isoguanine 
istradefylline  
keto-phenylpyruvic acid +   
L-alaninate +  
L-alanine +   
L-alaninium +  
L-aspartate(1-) +  
L-aspartate(2-) +  
L-cysteinate(1-) +  
L-cysteinate(2-) 
L-cysteinium +  
L-cysteinyl radical +  
L-erythro-isocitrate(3-) 
L-galactose 1-phosphate +  
L-galactose 1-phosphate(2-) +  
L-homocysteine zwitterion 
L-ribulose 5-phosphate(2-) 
L-threo-isocitrate(3-) 
L-tyrosinate(1-) 
L-tyrosinate(2-) +  
L-tyrosine +   
L-tyrosinium +  
L-xylulose 5-phosphate(2-) 
lipoate +  
lipoic acid +   
LSM-1748 
malate(2-) +  
malic acid +   
mannose +   
methyladenine +   
methylguanine +   
methylhypoxanthine +  
methylthymine +  
Migrenin (TN) 
N(2),3-ethenoguanine 
N(4)-acetylcytosine 
N(6),N(6)-dimethyladenine  
N(6)-(1,2-dicarboxyethyl)-AMP 
N(6)-carbamoylmethyl-2'-deoxyadenosine 
N(6)-carbamoylmethyladenine 
N(6)-hydroxyadenine 
N,N,N-trimethylglycinium +  
N-(4-cyanophenyl)-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide 
N-benzyl-9-(alpha-D-glucosyl)adenine 
N-benzyladenine 
NAD +   
NADH +  
NADP zwitterion +   
NADP(+) +   
NADPH +  
O6-CYCLOHEXYLMETHOXY-2-(4'-SULPHAMOYLANILINO) PURINE 
oxalatosuccinate(3-) 
oxalosuccinic acid +  
oxetanocin A +  
pentifylline 
Pentoxifylline  
phentetramine 
phosphoenolpyruvate  
phosphoenolpyruvic acid 
phosphonatoenolpyruvate 
pimefylline 
Propentofylline 
protheobromine 
Proxyphylline 
pseudouridine +  
purine +   
purine 2'-deoxyribonucleoside 5'-phosphate(2-) +  
purines D-ribonucleoside +   
putrescine +   
pyruvate +  
pyruvic acid +   
reproterol 
ribulose 5-phosphate +  
S-adenosyl-L-homocysteinate 
S-adenosyl-L-homocysteine  
serinate +  
serine +   
serinium +  
spermidine +   
spermidine(3+) +  
spermine +   
spermine(4+) 
succinate(1-) 
succinic acid +   
tenofovir alafenamide 
Theacrine 
theodrenaline 
Theophylline sodium acetate 
thiamine(1+) diphosphate +  
thiouracil  
trans-aconitate(3-) 
trans-aconitic acid 
UDP-alpha-D-glucose  
UDP-alpha-D-xylose 
urate(2-) +  
uric acid +   
uridine +   
xanthine +   
xylulose 5-phosphate +   

Synonyms
Related Synonyms: 1,7-Dihydro-6H-purin-6-one ;   6(1H)-purinone ;   6-oxopurine ;   9H-purin-6(1H)-one ;   Formula=C5H4N4O ;   Hyp ;   InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10) ;   InChIKey=FDGQSTZJBFJUBT-UHFFFAOYSA-N ;   Purine-6-ol ;   SMILES=O=c1[nH]cnc2nc[nH]c12 ;   purin-6(1H)-one
Alternate IDs: CHEBI:14431 ;   CHEBI:24762 ;   CHEBI:43237 ;   CHEBI:5841
Xrefs: Beilstein:5811 ;   CAS:68-94-0 ;   DrugBank:DB04076 ;   ECMDB:ECMDB00157 ;   Gmelin:464558 ;   HMDB:HMDB0000157 ;   KEGG:C00262 ;   KNApSAcK:C00001502
Xref Mesh: MESH:D019271
Xrefs: MetaCyc:HYPOXANTHINE ;   PDBeChem:HPA ;   PMID:14253484 ;   PMID:1557408 ;   PMID:22735334 ;   PMID:23400363 ;   PMID:23670363 ;   PMID:8016081 ;   Reaxys:5811 ;   Wikipedia:Hypoxanthine ;   YMDB:YMDB00555

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.