Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

Ontology Browser

Term:
cyclosporin A metabolite M1cAL (CHEBI:140176)
Annotations: Rat: (0) Mouse: (0) Human: (0) Chinchilla: (0) Bonobo: (0) Dog: (0) Squirrel: (0) Pig: (0)
Parent Terms Term With Siblings Child Terms
(+)-(7R,7'R,8S,8'S)-4'-hydroxy-3,3',4,5,5'-pentamethoxy-7,7'-epoxylignan-9,9'-diol 
(+)-(7S,8R,8'R)-5,5'-dimethoxylariciresinol 
(+)-3'-hydroxylarreatricin 
(+)-5'-methoxylariciresinol 
(+)-DCA-CL 
(+)-lariciresinol +   
(+)-larreatricin 
(+)-pisiferal 
(+)-tephrorin A 
(+)-tephrorin B 
(-)-(7R,8S,7''S,8''R)-3,3'',5,5'-tetramethoxy-4''-hydroxy-4',7-epoxy-8',9'-dinor-4,8''-oxy-8,3'-sesquineolignan-7'',9,9''-triol-7'-al 
(-)-DCA-CL 
(-)-lariciresinol  
(-)-larreatricin 
(-)-secologanin 
(11R)-dihydroartemisinic aldehyde 
(13R)-13-dihydrocarminomycin 
(1R,2S)-nortilidine +  
(1R,2S,3S,4S)-4-formyl-2-methoxy-3-[(2E)-6-methylhept-2-en-2-yl]cyclohexyl (2E)-3-(4-methoxyphenyl)acrylate 
(1S)-1-hydroxy-23-oxo-24,25,26,27-tetranorcalciol 
(1S,2R)-nortilidine +  
(1S,3R)-dihydroxy-(20S)-[(5'R)-(2"-hydroxy-2"-propyl)-(2'S)-tetrahydrofuryl]-22,23,24,25,26,27-hexanor-1alpha-hydroxyvitamin D3 
(1S,3R)-dihydroxy-(20S)-[(5'S)-(2"-hydroxy-2"-propyl)-(2'R)-tetrahydrofuryl]-22,23,24,25,26,27-hexanor-1alpha-hydroxyvitamin D3 
(1S,3R)-dihydroxy-(20S)-[(5'S)-(2"-hydroxy-2"-propyl)-(2'S)-tetrahydrofuryl]-22,23,24,25,26,27-hexanor-1alpha-hydroxyvitamin D3 
(1S,7S)-7-amino-7-benzyl-8-oxohexahydro-1H-pyrazolo[1,2-a]pyridazine-1-carbaldehyde 
(1S,7S)-7-amino-7-methyl-8-oxohexahydro-1H-pyrazolo[1,2-a]pyridazine-1-carbaldehyde 
(20R)-28-hydroxylupen-30-al-3-one 
(2E)-2-ethyl-2-butenal 
(2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal 
(2R,5S)-linalyl oxide 
(2S)-2-(4-\{[(1R,2S)-2-hydroxycyclopentyl]methyl\}phenyl)propanoic acid 
(2S)-5,7-dimethoxy-8-formylflavanone 
(2S)-6-formyl-8-methyl-7-O-methylpinocembrin 
(2S)-8-formyl-5-hydroxy-7-methoxy-6-methylflavanone 
(4S)-4-(5,5-dimethylcyclohex-1-en-1-yl)cyclohex-1-ene-1-carbaldehyde 
(4S,5S)-4,5-dihydroxy-2,6-dioxohexanoic acid 
(5-hydroxyindol-3-yl)acetic acid  
(6-methoxy-2-naphthyl)acetic acid 
(7R)-6-deoxy-D-manno-oct-7-ulosuronic acid 
(7R)-7-hydroxylariciresinol 
(7R)-7-hydroxytaxiresinol 
(E)-2-((N-methylformamido)methylene) succinate 
(methylsulfanyl)acetaldehyde +  
(R)-4-dehydropantoic acid 
(±)-cis-Linalyl oxide 
1,1,1,3,3,3-hexafluoropropan-2-ol  
1-(3-chlorophenyl)piperazine  
1-[1-(1-adamantyl)butyl]-3-(2-oxolanylmethyl)thiourea 
1-hexadecanoyl-2-(7-oxoheptanoyl)-sn-glycero-3-phosphocholine 
1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine 
1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine  
1-p-menth-1-ene-9-al 
10,11-trans-dihydroxy-10,11-dihydrocarbamazepine +  
12-Epoxyobtusallene IV 
12-oxo-cis-dodec-9-enoic acid 
16-epivellosimine 
2'-deamino-2'-hydroxy-6'-dehydroparomamine 
2,3,4-trihydroxytetrahydrofuran +  
2,3-epoxygerianial 
2,5-dioxopentanoic acid 
2,6-dimethylaniline +   
2-(2',3-epoxy-1',3'-heptadienyl)-6-hydroxy-5-(3-methyl-2-butenyl)benzaldehyde 
2-(2-methyl-4-oxo-3-pyranyl)acetaldehyde 
2-(3,5-dioxo-4-phenyl-2-oxolanylidene)-2-phenylacetic acid methyl ester 
2-(4-oxo-2-propyl-3-pyranyl)acetaldehyde 
2-(carboxyethoxy)propanal 
2-(dichloromethyl)tetrahydrofuran 
2-[5-(2-hydroxypropyl)oxolan-2-yl]propanoic acid 
2-\{2-chloro-4-(methylsulfonyl)-3-[(tetrahydrofuran-2-ylmethoxy)methyl]benzoyl\}cyclohexane-1,3-dione +  
2-acetoxypropanal 
2-deoxy-2-fluoro-aldehydo-D-glucose +  
2-formylbenzoic acid 
2-formylglutaric acid 
2-formylporphyrin 
2-hydroxy-3-oxopropanoic acid 
2-hydroxyibuprofen 
2-methoxyacetaminophen glucuronide 
2-methoxyacetaminophen glucuronide(1-) 
2-methoxyacetaminophen sulfate 
2-methoxyacetaminophen sulfate(1-) 
2-methyl-3-oxopropanoic acid +  
20-oxo-5-O-beta-mycaminosyltylactone 
20-oxoleukotriene E4 
3''-adenylylstreptomycin 
3'-hydroxy-4'-methoxydiclofenac 
3'-hydroxydiclofenac 
3,4-dihydroxymandelaldehyde 
3,4-dihydroxymandelic acid  
3,5-dihydroxyphenylacetic acid 
3,6-anhydro-D-galactose 
3,6-anhydro-D-glucose 
3,8-dioxooct-5-enoyl-CoA 
3-(2,2,3-trimethylcyclopent-3-enyl)cyclohex-3-enecarbaldehyde 
3-(4-tert-butylamino-6-methylthiol-s-triazin-2-ylamino)propionaldehyde 
3-(N-Nitrosomethylamino)propionaldehyde 
3-[5-[2-[4-(2-carboxyethenyl)-3-oxo-5-propyl-2-furanyl]propan-2-yl]-4-oxo-2-propyl-3-furanyl]-2-propenoic acid 
3-acetamido-3,5-dideoxy-L-lyxo-hept-6-ulopyranosuronic acid 
3-chloroacrylaldehyde 
3-chlorobenzoic acid 
3-dehydro-L-erythrose 4-phosphate 
3-formylsalicylic acid 
3-formylthiophene 
3-furaldehyde 
3-hydroxy-1-methoxy-9,10-dioxo-2-anthracenecarboxaldehyde 
3-hydroxy-2,2-dimethylbutyric acid 
3-hydroxylubimin 
3-Ketoapotrichothecene 
3-methyl-4-\{[(1Z)-prop-1-en-1-yl]oxy\}butanal 
4',5-dihydroxydiclofenac 
4'-hydroxydiclofenac  
4'-O-demethylsordarin 
4-(2,2,3-trimethylcyclopent-3-enyl)cyclohex-3-enecarbaldehyde 
4-(acetylamino)-3-hydroxyphenyl hydrogen sulfate 
4-(acetylamino)-3-hydroxyphenyl sulfate 
4-(methylamino)antipyrine 
4-(trifluoromethyl)phenol 
4-acetamidoantipyrine 
4-aminoantipyrine 
4-ethoxyaniline +   
4-formylaminoantipyrine 
4-formylsalicylic acid 
4-hydroxy-2,6-dimethylaniline 
4-hydroxy-6-methylaniline 
4-Methylaminobutanal 
4-oxobutyl alpha-L-rhamnoside +  
4-quinolone-3-carboxaldehyde 
5'-hydroxyomeprazole 
5-(2'-formylethyl)-4,6-dihydroxypicolinic acid 
5-carboxy-2'-deoxyuridine 
5-dehydro-4-deoxy-2-O-sulfo-D-glucuronic acid 
5-dehydro-4-deoxy-D-glucuronic acid +  
5-fluorouridine 5'-monophosphate 
5-formyluracil 
5-hydroxydiclofenac  
5-hydroxydiclofenac quinone imine 
5-O-beta-D-mycaminosyl-20-oxotylonolide 
5-O-mycaminosyltylonolide 
6'-oxoparomamine 
6-(tetrahydrofuran-2-ylmethoxy)-9H-purin-2-amine 
6-azauridine +   
6-formylpterin  
6-methoxy-2,6-dimethyloctanal 
7-deoxyloganetic aldehyde 
9-(tetrahydrofuryl)adenine  
9beta-pimara-7,15-dien-19-al 
acetaldehyde +   
acetaminophen O-beta-D-glucosiduronic acid  
acetohydrazide +   
acetylleucyl-leucyl-norleucinal  
ACT-132577 +   
ACT-333679 +  
adefovir +   
alborixin  
alcaftadine 
aldehydic acid +   
aldehydo-ascarylose 
aldehydo-L-rhamnose 
aliphatic aldehyde +   
alkanal 
alkyltetrahydrofuran +  
alloxanthine +   
alpha,beta-unsaturated aldehyde +   
alpha-CH2-containing aldehyde +   
AMCR277A 
AMCR277B 
amino aldehyde +   
andrastin A  
arenecarbaldehyde +   
aripiprazole  
artemisinic aldehyde +  
arugosin A (hydroxy-aldehyde form) 
aryltetrahydrofuran +  
astragaloside I 
astragaloside II 
atenolol acid 
atenolol-desisopropyl 
aureothin 
aziridine aldehyde +  
azure B  
beta-Aminopropion aldehyde 
Bisabolol oxide B 
bromuconazole  
buddlenol A 
butanals +   
butynal +  
cabraleadiol 
cabraleadiol monoacetate 
cabraleone 
carbamazepine-10,11-epoxide  
carboxyibuprofen 
carboxyibuprofen(2-) 
carotenal +  
ceftaroline +  
chaetopyranin 
Chalcogran 
citronellal +   
clethroidoside G 
clopidogrel carboxylic acid 
cornusalterin L 
cotinine N-oxide 
cycloastragenol +   
cyclosporin A metabolite M1 +  
cyclosporin A metabolite M10 
cyclosporin A metabolite M13 
cyclosporin A metabolite M16 +  
cyclosporin A metabolite M17 +  
cyclosporin A metabolite M18 +  
cyclosporin A metabolite M1A 
cyclosporin A metabolite M1cAL 
A cyclosporin A derivative that is cyclosporin A metabolite M18 in which the 2-hydroxyethyl substituent of the dioxolane ring has been oxidised to give the corresponding aldehyde.
cyclosporin A metabolite M21 +  
cyclosporin A metabolite M25 
cyclosporin A metabolite M26 
cyclosporin A metabolite M8 +  
cyclosporin A metabolite M9 
D617 
Dehydrongaione 
demethyllactenocin 
demethylmacrocin 
deoxyflindissone 
desmethyl loperamide 
desmethyldoxepin +  
desmethylnaproxen  
desmethylnaproxen sulfate 
desmethylnaproxen(1-) 
desmethylranitidine 
dialdehyde +   
diclofenac beta-D-glucosiduronic acid 
didesethylflurazepam 
dihydrochanoclavine-I aldehyde 
dinotefuran +   
dioxoaminopyrine 
doxorubicinol 
Esulatin H, (rel)- 
ethisterone 
ethyl 4-oxobutanoate 
Euphorbiaproliferin C 
Euphorbiaproliferin G 
faropenem +  
faropenem(1-) +  
fatsicarpain C 
fellutamide C 
fellutamide D 
fenofibric acid 
fluoroacetaldehyde 
formaldehyde +   
formylindanone +  
formylthiophene 
fumagalone +  
furfural 
futokadsurin A 
futokadsurin B 
futokadsurin C 
gamma-glutamyl-gamma-aminobutyraldehyde 
GI254023X 
gibberellin A12 aldehyde 
gibberellin A24 
gigantetronenin 
gigantrionenin 
glyceraldehyde 3-phosphate +   
glycinexylidide +  
glycolaldehyde phosphate 
glycolaldehyde triphosphate 
glycolaldehydes +   
glyoxylate ester +  
gypsogenin +  
gypsosaponin A 
gypsosaponin B 
gyromitrin 
hadacidin 
Helminthosporal 
heteroarenecarbaldehyde +   
Hibiscoquinone A 
hydroxyalbendazole 
hydroxyaldehyde +   
hydroxyfenbendazole 
hydroxypolyether aldehyde +  
imidaprilat  
imidazolylacetaldehyde +  
indoleacetaldehyde +   
indometacin +   
integrastatin B 
inumakal 
Ipomoeamarone 
Isobenzan 
Isovelleral 
ixazomib +   
jaspamide G 
Jatrophone 
josamycin  
ketoaldehyde +   
leupeptin  
lilac aldehyde +  
linalool 3,6-oxide primeveroside 
Linalyl oxide 
liphagal 
lucialdehyde B 
lucialdehyde C 
luzonial A 
luzonial B 
luzonidial B 
macrocin 
manassantin A 
manassantin B 
maoecrystal Z 
marneral 
meso-3,3'-didemethoxynectandrin B 
mevinolinic acid 
mollicellin B 
mollicellin C 
mollicellin E 
mollicellin F 
mollicellin H 
mollicellin J 
mollicellin K 
mollicellin L 
mollicellin M 
mollicellin N 
monoethylglycinexylidide +   
morellin +  
mutalomycin 
N,N-didesmethylvenlafaxine 
N,O-didesmethylvenlafaxine 
N-acetylsulfamethoxazole 
N-desmethylvenlafaxine 
N-substituted pyrraline +  
nitrazepam +   
nitrososulfadiazine 
nitrososulfapyridine 
norfentanyl 
nortriptyline  
norverapamil  
nucleoside +   
O-desmethylvenlafaxine 
Obtusallene X, (rel)- 
ocotillone 
omega-oxo fatty acid +   
oxidopamine  
oxolane +   
oxyphenbutazone +   
paliperidone 
pannarin 
paracetamol sulfate +   
perillyl aldehyde  
perindoprilat 
phenylacetaldehydes +   
Polygodial  
polyneuridine aldehyde 
posaconazole  
prednisolone +   
procainamide 4-hydroxylamine 
proglumide +  
propanals +   
prosolanapyrone III 
psilocin +  
pyrazine-2-carboxylic acid  
pyridine N-oxide +   
pyrraline +  
quillaic acid +  
quillaic acid alpha-L-Arap-(1->4)-alpha-L-Arap-(1->3)-beta-D-Xylp-(1->4)-alpha-L-Rhap-(1->2)-beta-D-fucopyranosyl ester 
rac-nortilidine 
ramiprilat  
ranitidine N-oxide 
ranitidine-S-oxide 
rel-(-)-(7S,7'R,8S,8'R)-4,4'-dihydroxy-3,3',5'-trimethoxy-7,7'-epoxylignan 
rel-hopan-27-al-6beta,11alpha,22-triol 
retinals +   
ritalinic acid  
rosaramicin 
rubiarboside G 28-al 
S-(4-oxobutan-2-yl)glutathione 
S-(5-acetamido-2-hydroxyphenyl)-N-acetyl-L-cysteinate 
S-(5-acetamido-2-hydroxyphenyl)-N-acetyl-L-cysteine 
sapinmusaponin Q 
sapinmusaponin R 
SN-38 +   
sordaricin 
spectinabilin 
spiramycin I 
spiramycin II 
spiraprilat +   
steroid aldehyde +   
Succinic aldehyde 
sulfadiazine hydroxylamine 
sulfapyridine hydroxylamine 
taxiresinol 
tedizolid 
tenofovir (anhydrous) +   
teriflunomide  
tetrahydrofurancarboxylic acid +  
tetrahydrofuranol +   
tetrahydrofuranone +   
tetrahydrofurfuryl alcohol +  
tetrahydrofuryl ester +   
tetrahydrofuryl ether +  
tetrahydrofurylmethyl ester +  
theophylline +   
trandolaprilat 
trans-furan linalool oxide 
trichloroacetaldehyde +   
tylosin 
uridine +   
uridine-5'-aldehyde 
valeraldehyde +  
vellosimine 
versiconal hydroxyaldehyde form 
Vitex norditerpenoid 1 
Vitex norditerpenoid 2 
vladinol D 
WR-1065  
Z-Val-Phe-H  
zofenoprilat 
zymosterol intermediate 1b 

Synonyms
Exact Synonyms: {(4R,5R)-5-[(2S,5S,11S,14S,17S,20S,23R,26S,29S,32S)-5-ethyl-11,17,26,29-tetraisobutyl-14,32-diisopropyl-1,7,10,16,20,23,25,28,31-nonamethyl-3,6,9,12,15,18,21,24,27,30,33-undecaoxo-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2-yl]-4-methyltetrahydrofuran-2-yl}acetaldehyde
Related Synonyms: AM1cAL ;   Formula=C62H109N11O13 ;   InChI=1S/C62H109N11O13/c1-24-43-58(81)67(17)32-48(75)68(18)44(27-33(2)3)55(78)66-49(37(10)11)61(84)69(19)45(28-34(4)5)54(77)63-40(15)53(76)64-41(16)57(80)70(20)46(29-35(6)7)59(82)71(21)47(30-36(8)9)60(83)72(22)50(38(12)13)62(85)73(23)51(56(79)65-43)52-39(14)31-42(86-52)25-26-74/h26,33-47,49-52H,24-25,27-32H2,1-23H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/t39-,40+,41-,42?,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1 ;   InChIKey=UFWMVNJLCHMUKS-JFGKHBSWSA-N ;   M1cAL ;   SMILES=[C@H]1(N(C([C@@H](N(C([C@@H](N(C)C([C@@H](N(C([C@H](NC([C@@H](NC([C@@H](N(C([C@@H](NC([C@@H](N(C)C(CN(C([C@@H](NC1=O)CC)=O)C)=O)CC(C)C)=O)C(C)C)=O)C)CC(C)C)=O)C)=O)C)=O)C)CC(C)C)=O)CC(C)C)=O)C)C(C)C)=O)C)[C@]2([C@H](C)CC(O2)(CC=O)[H])[H] ;   cyclosporin A metabolite AM1cAL ;   cyclosporin metabolite AM1cAL ;   cyclosporin metabolite M1cAL ;   cyclosporine A metabolite AM1cAL ;   cyclosporine A metabolite M1cAL ;   cyclosporine metabolite AM1cAL ;   cyclosporine metabolite M1cAL
Xrefs: PMID:8745344 "Europe PMC" ;   PMID:8782089 "Europe PMC"

paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.