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Parent Terms Term With Siblings Child Terms
(+)-(12E,2S,3S,4R,5R,6R,9S,11S,15R)-3-benzoyloxy-5,6-epoxylathyr-12-en-15-ol-14-one 
(+-)-menthol 
(-)-(12E,2S,3S,4R,5R,6R,9S,11S,15R)-3-acetoxy-15-benzoyloxy-5,6-epoxylathyr-12-en-14-one 
(-)-(5E,12E,2S,3S,4S,9S,11S,15R)-15-benzoyloxylathyra-5,12-dien-3-ol-14-one 
(-)-(6Z,12E,2S,3S,4R,5R,9S,11S,15R)-3-acetoxy-15-benzoyloxylathyra-6,12-dien-5-ol-14-one 
(-)-(6Z,12E,2S,3S,4R,5R,9S,11S,15R)-5-acetoxy-15-benzoyloxylathyra-6,12-dien-3-ol-14-one 
(1'S,5'S)-averufin 
(2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol 
(2R,4S)-N-[(1S,2R)-2-hydroxyindan-1-yl]-2-phenylmethyl-4-hydroxy-5-[(2S)-4-(benzofuran-2-ylmethyl)-2-(tert-butylaminocarbonyl)piperazin-1-yl]pentanamide 
(2R,4S)-N-[(1S,2R)-2-hydroxyindan-1-yl]-5-[(2S)-2-(tert-butylaminocarbonyl)-4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]-4-hydroxy-2-(phenylmethyl)pentanamide 
(2S,4S,5S)-5-[((2S)-2-\{(3R)-3-benzyl-4-[(4-methylpiperazin-1-yl)carbonyl]-2-oxopiperazin-1-yl\}hexanoyl)amino]-N-butyl-6-cyclohexyl-4-hydroxy-2-isopropylhexanamide 
(4S,5S)/(4R,5R)-2,2,4-triethyl-5-methyl-1,3-dioxolane 
(E)-cinnamaldehyde +   
(E)-trans-miyabenol C 
(R)-adrenaline +   
(R)-efonidipine +  
(R)-oxybutynin +   
(R,R)-tramadol +   
(R,R)-tramadol hydrochloride +  
(S)-4,4'-(1-methylethane-1,2-diyl)bis(piperazine-2,6-dione) 
(S)-efonidipine +  
(S,S)-tramadol +   
(S,S)-tramadol hydrochloride +  
1,3-bis-([3-(4-\{3-[3-nitro-5-(galactopyranosyloxy)benzoylamino]propyl\}piperazin-1-yl)propylamino]carbonyloxy)-2-aminopropane 
1,3-bis-([3-[3-[3-(4-\{3-[3-nitro-5-(galactopyranosyloxy)benzoylamino]propyl\}piperazin-1-yl)propylamino-3,4-dioxocyclobutenyl]aminopropoxyethoxyethoxy]propyl]aminocarbonyloxy)-2-aminopropane 
1,3-bis-([[3-(4-\{3-[3-nitro-5-(galactopyranosyloxy)benzoylamino]propyl\}piperazin-1-yl)propylamino-3,4-dioxocyclobutenyl]aminoethyl]aminocarbonyloxy)-2-aminopropane 
1,3-dinitroglycerol +  
1,3-dioxolane +  
1-(1-methylindol-5-yl)-3-(3-methyl-1,2-thiazol-5-yl)urea 
1-(2-(2-Hydroxyethoxy)ethyl)piperazine 
1-(3,4-dihydroxy-5-nitrophenyl)-3-\{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl\}propan-1-one 
1-(3-chloro-5-benzo[b][1]benzoxepinyl)-4-methylpiperazine 
1-(4-\{[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy\}phenyl)-4-isopropylpiperazine +   
1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine  
1-[2-hydroxy-4-(2-hydroxy-5-methylcyclopentylcarbamoyl)-5-phenylpentyl]-4-(3-pyridin-3-ylpropionyl)piperazine-2-(N-tert-butyl)carboxamide 
1-acetyl-4-(4-\{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy\}phenyl)piperazine +   
1-benzylpiperazine  
15beta-O-benzoyl-5alpha-hydroxyisolathyrol 
16alpha,17alpha-dihydroxyprogesterone acetophenide +  
2,2-diphenyl-4-piperidinomethyl-1,3-dioxolane methiodide 
2,3,4-Trioxycyclopentanone 
2,3-diphenyl-N-(2-piperazin-1-ylethyl)furo[2,3-b]pyridin-4-amine 
2,4,5-trimethyl-1,3-dioxolane 
2-(1-phenylethyl)-1,3-dioxolane 
2-(4-bromo-6,6,6-trichloro-2-methyl-2-hexanyl)-1,3-dioxolane 
2-(4-ethyl-1-piperazinyl)-5-[(5-methyl-2-furanyl)methylidene]-4-thiazolone 
2-(4-methyl-1-piperazinyl)ethanamine 
2-(6-heptynyl)-1,3-dioxolane 
2-[2-(2-methoxyethoxy)ethoxy]-1,3-dioxolane 
2-[4-(1,4-dithiepan-6-yl)-1-propan-2-yl-2-piperazinyl]ethanol 
2-aminoethoxydiphenylborane  
2-isopropyl-1,3-dioxolane 
2-methoxyidazoxan  
2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine 
2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine  
2-sec-butyl-1,3-dioxolane 
21-phosphorifampicin 
27-O-demethylrifamycin SV 
3,4-O-[(1S)-1-carboxyethylidene]-beta-D-galactose 
3-(galactopyranosyloxy)-N-(3-\{4-[3-(\{2-[(3-\{4-[3-(\{[3-(galactopyranosyloxy)-5-nitrophenyl]carbonyl\}amino)propyl]piperazin-1-yl\}propyl)amino]-3,4-dioxocyclobut-1-en-1-yl\}amino)propyl]piperazin-1-yl\}propyl)-5-nitrobenzamide 
3-[4-(3-chlorophenyl)piperazin-1-yl]-1,1-diphenylpropan-2-ol 
3-[4-(3-chlorophenyl)piperazin-1-yl]-1,1-diphenylpropan-2-ol hydrochloride 
3-[4-[4-oxo-5-(thiophen-2-ylmethylidene)-2-thiazolyl]-1-piperazinyl]propanenitrile 
3-pyridinemethanol  
4,4'-propane-1,3-diyldipiperazine-2,6-dione 
4,5-dimethyl-2-pentadecyl-1,3-dioxolane 
4,6-pyr-beta-D-GlcpNAc-(1->3)-alpha-D-Galp-(1->4)-beta-L-Rhap 
4-[2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-1,3-dioxolan-2-yl]benzoic acid 
4-[4-(biphenyl-2-ylmethyl)piperazin-1-yl]-N-[4-\{[1,1-dimethyl-2-(phenylthio)ethyl]amino\}-3-nitrobenzenesulfonyl]benzamide 
4-fluoro-N-\{2-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]ethyl\}benzamide 
5,6-diphenyl-N-(2-piperazin-1-ylethyl)furo[2,3-d]pyrimidin-4-amine 
5beta-dihydrotestosterone 
6-(cyclohexylamino)-9-[2-(4-methylpiperazin-1-yl)ethyl]-9H-purine-2-carbonitrile 
6-\{4-[(4-ethylpiperazin-1-yl)methyl]phenyl\}-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine 
7-epiclusianone 
8-OH-DPAT  
9-cyclopentyl-6-\{2-[3-(4-methylpiperazin-1-yl)propoxy]phenylamino\}-9H-purine-2-carbonitrile 
[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl hydrogen hex-5-enylphosphonate 
[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl hydrogen hex-5-enylphosphonate 
acetophenazine +   
acetylcholine +   
ACT-333679 +  
adenosine +   
aflatoxin B1 endo-8,9-oxide 
aflatoxin M1 8,9-epoxide 
ajmalicine  
algestone acetonide 
alosetron +  
alosetron hydrochloride 
amlodipine +   
amlodipine benzenesulfonate +  
amomol A 
amomol B 
anandamide +   
Arg-Phe 
aripiprazole  
aripiprazole lauroxil 
asenapine 
asenapine maleate 
asparagoside F 
avanafil 
avermectin +   
avermectin analogue +   
azaconazole 
azaperone  
azilsartan medoxomil 
bamethan +  
BAY 41-2272 
benzyl \{(1S)-5-amino-1-[(S)-hydroxy(5-\{[4-(4-phenylbutanoyl)piperazin-1-yl]methyl\}-1,2,4-oxadiazol-3-yl)methyl]pentyl\}carbamate 
benzyl nicotinate 
bepridil +   
beraprost  
beraprost sodium 
beta-casomorphin-7 (human) 
betahistine  
bevantolol +   
bevantolol hydrochloride +  
BGJ-398 
bradykinin +  
bucladesine  
buclizine  
buspirone  
carbon dioxide  
carbon monoxide  
cariprazine  
cariprazine hydrochloride 
carphenazine +  
carpronium chloride 
carvedilol  
CGP-42112A  
chaetoxanthone A 
chaetoxanthone B 
Chloralose  
cilnidipine  
cilostazol  
cinaciguat  
cinnarizine  
clomipramine  
clomipramine hydrochloride 
clonixin 
clonixin lysine salt 
clopenthixol +   
clozapine  
cobalt dichloride +   
convallatoxin 
cromoglycic acid 
cyclandelate 
cyclizine +  
cyproheptadine +   
cyproheptadine hydrochloride sesquihydrate 
dapiprazole 
desonide 
devapamil 
diallyl trisulfide  
diazoxide  
diethylstilbestrol +   
difenoconazole  
difloxacin 
dihydroergocristine +  
dihydroergocristine mesylate +  
diltiazem  
diltiazem hydrochloride 
diltiazem(1+) +  
dinitrogen oxide  
dipyridamole  
domiodol 
dotarizine 
An N-alkylpiperazine in which the two amino hydrogens of piperazine have been replaced by diphenylmethyl and 3-(2-phenyl-1,3-dioxolan-2-yl)propyl groups. A calcium channel blocker and serotonin (5-HT2) receptor antagonist used in the treatment of migraine.
doxazosin +   
dyphylline +  
efonidipine 
enrofloxacin  
eprazinone 
ergoloid mesylate 
eribulin 
erythrityl tetranitrate 
esoxybutynin +   
etaconazole 
ethosuximide +   
ethyl [4-(\{[2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl\}sulfanyl)phenyl]carbamate +  
eupatorin  
fabesetron 
felodipine  
fenoldopam  
fleroxacin 
flibanserin 
flunisolide  
fluocinolone acetonide  
flupenthixol  
fluphenazine +   
fluphenazine decanoate 
gabapentin +   
gabapentin enacarbil 
GR 113808  
GR 127935  
GR 127935 hydrochloride 
gramine 
graminone B 
granisetron  
haloperidol  
HG-9-91-01 
hydralazine +   
hydralazine hydrochloride 
hydrogen sulfide +   
hydroxyzine +   
ICRF-193 
Ile(5)-angiotensin II (1-7) 
iloperidone  
iloprost  
iodinated glycerol 
iodocyanopindolol  
isoamyl nitrite 
isoflavipucine 
isosorbide dinitrate  
isosorbide mononitrate  
itraconazole  
JWH-133 
ketanserin  
khellin 
lactiflorin 
lamotrigine  
levodropropizine 
levosimendan 
lificiguat 
linkable imatinib analogue 
LRRK2-IN-1 
lurasidone 
lurasidone hydrochloride  
LY-310762 
LY-310762 hydrochloride 
magnesium sulfate +   
marbofloxacin  
masitinib 
mesulergine  
metergoline  
methacholine +   
methiothepin  
methiothepin maleate 
methotrimeprazine 
methyl 9-hydroperoxy-9-\{5'-[(1E)-1-propen-1-yl]-3,3'-bi-1,2-dioxol-5-yl\}nonanoate 
methyl brevifolincarboxylate 
methysergide  
metofenazate 
mianserin +   
milrinone  
minoxidil  
mirodenafil 
mirtazapine  
morphine +   
N-(2,6-dimethylphenyl)-2-\{4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl\}acetamide +   
N-(2-hydroxyethyl)piperazine +   
N-(2-hydroxyindan-1-yl)-5-[2-(tert-butylaminocarbonyl)-4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]-4-hydroxy-2-(1-phenylethyl)pentanamide 
N-(2-hydroxyindan-1-yl)-5-[2-(tert-butylaminocarbonyl)-4-(3-pyridylmethyl)piperazin-1-yl]-4-hydroxy-2-(1-phenylethyl)pentanamide 
N-(4-\{1-[4-(4-acetylpiperazin-1-yl)-trans-cyclohexyl]-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl\}-2-methoxyphenyl)-1-methyl-1H-indole-2-carboxamide 
N-(4-\{4-amino-1-[4-(4-methylpiperazin-1-yl)-trans-cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl\}-2-methoxyphenyl)-1-methyl-1H-indole-2-carboxamide 
N-(sulfoalkyl)piperazine +  
N-\{3-[4-(3-aminopropyl)piperazin-1-yl]propyl\}-3-(2-thiophen-2-ylacetylamino)-5-(3,4,5-trihydroxy-6-hydroxymethyltetrahydropyran-2-yloxy)benzamide 
N-\{3-[4-(3-aminopropyl)piperazin-1-yl]propyl\}-3-nitro-5-(D-galactopyranosyl)benzamide +  
N-arachidonoyl-L-serine 
N-demethylmirtazapine 
N-desmethylclozapine  
N-ethyl-5'-carboxamidoadenosine  
N-methylpiperazine +   
N-methylquipazine +   
n-pentyl nitrite 
NAN 190 
NAN 190 hydrobromide  
nebivolol  
nebivolol hydrochloride +  
nefazodone +   
nelociguat 
nemadipine-A 
neocarzinostatin chromophore 
neocarzinostatin-glutathione chromophore 
netupitant +  
nickel dichloride +   
nicorandil  
nicotinic acid +   
nifedipine  
nigerazine A 
nigerazine B 
nigragillin 
nimodipine  
nintedanib  
nisoldipine  
nitrendipine  
nitric oxide  
nitroflurbiprofen  
nitroglycerin  
norverapamil  
ochratoxin A +   
ochratoxin B  
ofloxacin +   
olanzapine  
omega-conotoxin GVIA  
onalespib 
oxapropanium 
oxybutynin +   
oxypeucedanin hydrate acetonide 
oxytocin  
paliperidone 
paliperidone palmitate  
palonosetron  
palonosetron hydrochloride +  
papaverine  
partial prostacyclin agonist +  
pederin 
pefloxacin +  
pentaerythritol tetranitrate  
perazine +   
perphenazine +   
petasin 
phenguignardic acid 
phentolamine  
picrotoxinin +   
pifarnine 
pimavanserin 
pimavanserin tartrate 
pimobendan  
pimozide  
pindolol +   
pinocembrin +   
pipacycline 
pipamperone 
pipamperone dihydrochloride 
pizotifen  
pizotifen malate 
pizotifen maleate 
PQIP 
praliciguat 
pregabalin  
prochlorperazine +   
proglumetacin +  
promazine +   
propiconazole  
propiomazine +  
propranolol +   
prostaglandin E1 +   
quetiapine +   
quinaprilat  
razoxane +   
rel-(2R/S,4R,5R)-4-ethyl-5-methyl-2-(1-methylethyl)-1,3-dioxolane 
rel-(2R/S,4S,5S)-4-ethyl-5-methyl-2-(1-methylethyl)-1,3-dioxolane 
rel-(2R/S,4S,5S)-4-ethyl-5-methyl-2-(1-methylpropyl)-1,3-dioxolane 
rel-(2R/S,4S,5S)-4-ethyl-5-methyl-2-(2-methylpropyl)-1,3-dioxolane 
rifampicin +   
rifamycin SV +   
rifamycin SV hemiaminal 
rifapentine  
rifaximin  
risperidone  
ritanserin  
RS 39604  
RS 39604 hydrochloride 
S-nitroso-L-cysteine +   
S-nitroso-N-acetyl-D-penicillamine  
SB 224289 
SB 224289 hydrochloride 
SDZ 35-682 
selexipag 
sertindole  
sildenafil +   
sildenafil citrate  
SKF-96365 hydrochloride  
sodium nitroprusside +  
sodium nitroprusside dihydrate 
sotrastaurin  
spathulenol  
sphingosine 1-phosphate  
spiperone  
spiramide 
spiro[[7-methoxy-5-methyl-1,2-dihydronaphthalene]-3,1'-[5-hydroxy-9-[2-methylamino-2,6-dideoxygalactopyranosyloxy]-5-(2-oxo-1,3-dioxolan-4-yl)-3a,5,9,9a-tetrahydro-3H-1-oxacyclopenta[a]-s-indacen-2-one]] 
spiroketal +   
spiroxamine  
streptolydigin 
tadalafil  
talmapimod 
tandospirone 
tetramethylpyrazine  
TG101209 
thapsigargin  
theobromine  
theophylline +   
thiethylperazine +   
thiopropazate 
thioproperazine 
thioridazine +   
tolazoline  
topiramate  
tramadol  
tramadol hydrochloride 
tranilast  
trans-(2R/S)-2,4-diethyl-2,5-dimethyl-1,3-dioxolane 
trazodone +   
treprostinil +   
triacsin C  
triamcinolone acetonide  
Triethylenediamine  
trifluoperazine +   
triforine  
trimethaphan +   
troglitazone  
tropanyl 3,5-dimethylbenzoate 
tropisetron  
tropisetron hydrochloride 
U50488  
vanoxerine 
vardenafil 
venetoclax  
verapamil  
vericiguat 
vilazodone 
vincamine  
visnagin 
vortioxetine  
vortioxetine hydrobromide 
yohimbine  
zaragozic acid A +   
zaragozic acid C 
zhankuic acid B 
ziprasidone +   
zofenopril 
zofenopril calcium 
zofenoprilat 
zofenoprilat arginine 
zuclopenthixol 

Synonyms
Exact Synonyms: 1-(Diphenylmethyl)-4-[3-(2-phenyl-1,3-dioxolan-2-yl)propyl]piperazine
Related Synonyms: 1-(Diphenylmethyl)-4-[3-(2-phenyl-1,3-dioxolan-2-yl)propyl]piperazin ;   FI-6026 ;   Formula=C29H34N2O2 ;   InChI=1S/C29H34N2O2/c1-4-11-25(12-5-1)28(26-13-6-2-7-14-26)31-21-19-30(20-22-31)18-10-17-29(32-23-24-33-29)27-15-8-3-9-16-27/h1-9,11-16,28H,10,17-24H2 ;   InChIKey=LRMJAFKKJLRDLE-UHFFFAOYSA-N ;   SMILES=C1CN(CCN1CCCC2(OCCO2)C3=CC=CC=C3)C(C4=CC=CC=C4)C5=CC=CC=C5 ;   dotarizina ;   dotarizinum
Xrefs: CAS:84625-59-2 ;   Chemspider:49929 ;   PMID:10082213 ;   PMID:10347616 ;   PMID:10483512 ;   PMID:10516641 ;   PMID:10592122 ;   PMID:10672335 ;   PMID:10763515 ;   PMID:10785251 ;   PMID:10940353 ;   PMID:11140170 ;   PMID:11164387 ;   PMID:14637173 ;   PMID:16153637 ;   PMID:21125446 ;   PMID:7881736 ;   PMID:7892769 ;   PMID:8153146 ;   PMID:8748852 ;   PMID:8981299 ;   PMID:9053586 ;   PMID:9112089 ;   PMID:9286620 ;   PMID:9379783 ;   PMID:9416324 ;   PMID:9658668 ;   PMID:9757621 ;   Patent:EP97340 ;   Patent:US4883797 ;   Reaxys:6879159 ;   Wikipedia:Dotarizine

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.