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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:acetylcholine signaling pathway
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Accession:PW:0000841 term browser browse the term
Definition:Acetylcholine signaling plays important roles in the central and peripheral nervous systems and exerts both excitatory and inhibitory effects. It is synthesized from acetyl-CoA and choline by choline O-acetyltransferase.
Synonyms:exact_synonym: ACh signaling pathway
 related_synonym: Acetylcholine binding and downstream events;   acetylcholine receptor signaling pathway
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acetylcholine signaling pathway via muscarinic acetylcholine receptor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase ISO RGD PMID:17786266 RGD:8549506 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Chat choline O-acetyltransferase ISO RGD PMID:23677775 RGD:8549504 NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093 		JBrowse link
G Grk2 G protein-coupled receptor kinase 2 ISO RGD PMID:23759942 RGD:8549590 NCBI chr 1:201,580,823...201,601,580
Ensembl chr 1:201,581,480...201,601,582 		JBrowse link
G Grk5 G protein-coupled receptor kinase 5 ISO RGD PMID:19478075 RGD:8549592 NCBI chr 1:260,028,269...260,223,699
Ensembl chr 1:260,028,242...260,218,701 		JBrowse link
G Rgs2 regulator of G-protein signaling 2 ISO RGD PMID:22685433 RGD:8549594 NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385 		JBrowse link
G Rgs4 regulator of G-protein signaling 4 ISO RGD PMID:22685433 RGD:8549594 NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068 		JBrowse link
G Rgs6 regulator of G-protein signaling 6 ISO RGD PMID:22685433 RGD:8549594 NCBI chr 6:102,264,451...102,796,311
Ensembl chr 6:102,264,447...102,824,753 		JBrowse link
G Slc18a3 solute carrier family 18 member A3 ISO RGD PMID:23677775 RGD:8549504 NCBI chr16:7,713,630...7,716,491 JBrowse link
G Slc5a7 solute carrier family 5 member 7 ISO RGD PMID:23677775 RGD:8549504 NCBI chr 9:7,595,440...7,626,258
Ensembl chr 9:7,595,444...7,626,258 		JBrowse link
acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphai protein family term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrm2 cholinergic receptor, muscarinic 2 ISO RGD PMID:23841840 RGD:8549585 NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103 		JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 ISO RGD PMID:23841840 RGD:8549585 NCBI chr 3:77,893,425...77,901,166
Ensembl chr 3:77,893,425...77,901,159 		JBrowse link
G Gnai1 G protein subunit alpha i1 ISO RGD PMID:23759942 RGD:8549590 NCBI chr 4:16,814,000...16,898,119
Ensembl chr 4:16,814,001...16,896,417 		JBrowse link
G Gnai2 G protein subunit alpha i2 ISO RGD PMID:23759942 RGD:8549590 NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979 		JBrowse link
acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphaq protein family term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrm1 cholinergic receptor, muscarinic 1 ISO RGD PMID:23841840 RGD:8549585 NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356 		JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 ISO RGD PMID:23841840 RGD:8549585 NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278 		JBrowse link
G Chrm5 cholinergic receptor, muscarinic 5 ISO RGD PMID:23841840 RGD:8549585 NCBI chr 3:99,284,846...99,337,252
Ensembl chr 3:99,284,846...99,337,252 		JBrowse link
G Gna11 G protein subunit alpha 11 ISO RGD PMID:23759942 RGD:8549590 NCBI chr 7:8,163,520...8,177,863
Ensembl chr 7:8,162,750...8,179,812 		JBrowse link
G Gna14 G protein subunit alpha 14 ISO RGD PMID:23759942 RGD:8549590 NCBI chr 1:213,714,993...213,900,083
Ensembl chr 1:213,716,020...213,897,423 		JBrowse link
G Gnaq G protein subunit alpha q ISO RGD PMID:23759942 RGD:8549590 NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672 		JBrowse link
acetylcholine signaling pathway via nicotinic acetylcholine receptor term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase ISO RGD PMID:17786266 RGD:8549506 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Agrn agrin ISO RGD PMID:23032192 RGD:8549508 NCBI chr 5:166,749,306...166,782,212
Ensembl chr 5:166,749,310...166,786,003 		JBrowse link
G Chat choline O-acetyltransferase ISO RGD PMID:23677775 RGD:8549504 NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093 		JBrowse link
G Chrna1 cholinergic receptor nicotinic alpha 1 subunit ISO RGD PMID:23032192 PMID:19126755 RGD:8549508, RGD:8549510 NCBI chr 3:58,454,763...58,469,832
Ensembl chr 3:58,454,744...58,469,840 		JBrowse link
G Chrna10 cholinergic receptor nicotinic alpha 10 subunit ISO RGD PMID:19126755 RGD:8549510 NCBI chr 1:156,487,279...156,494,277
Ensembl chr 1:156,487,279...156,491,476 		JBrowse link
G Chrna2 cholinergic receptor nicotinic alpha 2 subunit ISO RGD PMID:19126755 RGD:8549510 NCBI chr15:40,342,317...40,358,601
Ensembl chr15:40,342,317...40,358,601 		JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit ISO RGD PMID:19126755 RGD:8549510 NCBI chr 8:55,401,668...55,415,165
Ensembl chr 8:55,401,702...55,415,165 		JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit ISO RGD PMID:19126755 RGD:8549510 NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957 		JBrowse link
G Chrna5 cholinergic receptor nicotinic alpha 5 subunit ISO RGD PMID:19126755 RGD:8549510 NCBI chr 8:55,369,794...55,398,526
Ensembl chr 8:55,369,794...55,398,146 		JBrowse link
G Chrna6 cholinergic receptor nicotinic alpha 6 subunit ISO RGD PMID:19126755 RGD:8549510 NCBI chr16:64,697,741...64,704,441
Ensembl chr16:64,697,741...64,704,441 		JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit ISO RGD PMID:19126755 RGD:8549510 NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240 		JBrowse link
G Chrna9 cholinergic receptor nicotinic alpha 9 subunit ISO RGD PMID:19126755 RGD:8549510 NCBI chr14:42,235,218...42,241,939
Ensembl chr14:42,235,226...42,242,192 		JBrowse link
G Chrnb1 cholinergic receptor nicotinic beta 1 subunit ISO RGD PMID:23032192 PMID:19126755 RGD:8549508, RGD:8549510 NCBI chr10:54,501,096...54,516,418
Ensembl chr10:54,501,093...54,516,345 		JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit ISO RGD PMID:19126755 RGD:8549510 NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619 		JBrowse link
G Chrnb3 cholinergic receptor nicotinic beta 3 subunit ISO RGD PMID:19126755 RGD:8549510 NCBI chr16:64,713,438...64,751,360
Ensembl chr16:64,714,169...64,751,360 		JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit ISO RGD PMID:19126755 RGD:8549510 NCBI chr 8:55,417,583...55,437,027
Ensembl chr 8:55,418,313...55,437,027 		JBrowse link
G Chrnd cholinergic receptor nicotinic delta subunit ISO RGD PMID:23032192 PMID:19126755 RGD:8549508, RGD:8549510 NCBI chr 9:87,862,417...87,870,833
Ensembl chr 9:87,862,407...87,870,833 		JBrowse link
G Chrne cholinergic receptor nicotinic epsilon subunit ISO RGD PMID:23032192 PMID:19126755 RGD:8549508, RGD:8549510 NCBI chr10:55,331,211...55,339,923
Ensembl chr10:55,331,212...55,335,530 		JBrowse link
G Chrng cholinergic receptor nicotinic gamma subunit ISO RGD PMID:23032192 PMID:19126755 RGD:8549508, RGD:8549510 NCBI chr 9:87,878,085...87,884,193
Ensembl chr 9:87,878,085...87,914,482 		JBrowse link
G Dok7 docking protein 7 ISO RGD PMID:23032192 RGD:8549508 NCBI chr14:75,665,444...75,699,413
Ensembl chr14:75,666,744...75,699,386 		JBrowse link
G Lrp4 LDL receptor related protein 4 ISO RGD PMID:23032192 RGD:8549508 NCBI chr 3:77,429,600...77,483,593
Ensembl chr 3:77,429,798...77,483,593 		JBrowse link
G Musk muscle associated receptor tyrosine kinase ISO RGD PMID:23032192 RGD:8549508 NCBI chr 5:73,058,427...73,169,696
Ensembl chr 5:73,058,121...73,171,932 		JBrowse link
G Rapsn receptor-associated protein of the synapse ISO RGD PMID:23032192 RGD:8549508 NCBI chr 3:77,015,073...77,024,378
Ensembl chr 3:76,983,471...77,024,373 		JBrowse link
G Slc18a3 solute carrier family 18 member A3 ISO RGD PMID:23677775 RGD:8549504 NCBI chr16:7,713,630...7,716,491 JBrowse link
G Slc5a7 solute carrier family 5 member 7 ISO RGD PMID:23677775 RGD:8549504 NCBI chr 9:7,595,440...7,626,258
Ensembl chr 9:7,595,444...7,626,258 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    signaling pathway 2646
      chemical compound signaling pathway 86
        acetylcholine signaling pathway 40
          acetylcholine signaling pathway via muscarinic acetylcholine receptor + 19
          acetylcholine signaling pathway via nicotinic acetylcholine receptor 25
Path 2
Term Annotations click to browse term
  pathway 6092
    signaling pathway 2646
      signaling pathway pertinent to the brain and nervous system 465
        neuron-to-neuron signaling pathways 282
          neuron-to-neuron signaling pathway via the chemical synapse 280
            acetylcholine signaling pathway 40
              acetylcholine signaling pathway via muscarinic acetylcholine receptor + 19
              acetylcholine signaling pathway via nicotinic acetylcholine receptor 25
paths to the root