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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:insulin signaling pathway
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Accession:PW:0000143 term browser browse the term
Definition:Insulin, the peptide hormone secreted by pancreatic beta cells, plays essential roles in glucose and energy homeostasis. Insulin signaling activates two main intracellular pathways to regulate carbohydrate and fat metabolism and to prompt glucose absorption in insulin sensitive tissues such as skeletal muscle and adipocytes. Deregulation of the pathway has been associated with a number of conditions, primarily diabetes.
Synonyms:related_synonym: Signaling by Insulin receptor;   insulin receptor signaling pathway
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insulin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha IEA KEGG rno:04910 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457 		JBrowse link
G Acacb acetyl-CoA carboxylase beta IEA KEGG rno:04910 NCBI chr12:42,365,800...42,477,651
Ensembl chr12:42,366,548...42,457,655 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 ISO
IEA		 PID
KEGG
SMPDB		 PID:200014 SMP:00391 rno:04910 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 ISO
IEA		 PID
KEGG		 PID:200014 rno:04910 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817 		JBrowse link
G Akt3 AKT serine/threonine kinase 3 IEA KEGG rno:04910 NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708 		JBrowse link
G Bad BCL2-associated agonist of cell death IEA KEGG rno:04910 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase IEA KEGG rno:04910 NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463 		JBrowse link
G Calm1 calmodulin 1 IEA KEGG rno:04910 NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227 		JBrowse link
G Calm2 calmodulin 2 IEA KEGG rno:04910 NCBI chr 6:7,091,624...7,104,284
Ensembl chr 6:7,091,567...7,104,287
Ensembl chr15:7,091,567...7,104,287 		JBrowse link
G Calm3 calmodulin 3 IEA KEGG rno:04910 NCBI chr 1:77,590,668...77,597,776
Ensembl chr 1:77,589,230...77,592,207 		JBrowse link
G Calml3 calmodulin-like 3 IEA KEGG rno:04910 NCBI chr17:66,419,844...66,423,083
Ensembl chr17:66,419,882...66,423,175 		JBrowse link
G Calml5 calmodulin-like 5 IEA KEGG rno:04910 NCBI chr17:66,394,433...66,395,352 JBrowse link
G Cav1 caveolin 1 ISO PID PID:200014 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G Cbl Cbl proto-oncogene ISO
IEA		 PID
KEGG		 PID:200014 rno:04910 NCBI chr 8:44,487,824...44,571,620
Ensembl chr 8:44,489,410...44,571,176 		JBrowse link
G Cblb Cbl proto-oncogene B IEA KEGG rno:04910 NCBI chr11:48,589,878...48,756,940
Ensembl chr11:48,592,703...48,756,839 		JBrowse link
G Cblc Cbl proto-oncogene C IEA KEGG rno:04910 NCBI chr 1:79,439,975...79,456,755
Ensembl chr 1:79,439,977...79,456,755 		JBrowse link
G Crk CRK proto-oncogene, adaptor protein IEA KEGG rno:04910 NCBI chr10:60,530,469...60,556,703
Ensembl chr10:60,530,464...60,553,406 		JBrowse link
G Crkl CRK like proto-oncogene, adaptor protein IEA KEGG rno:04910 NCBI chr11:83,528,788...83,563,214
Ensembl chr11:83,526,530...83,563,238 		JBrowse link
G Dok1 docking protein 1 ISO PID PID:200014 NCBI chr 4:115,537,453...115,540,464
Ensembl chr 4:115,537,462...115,540,465 		JBrowse link
G Eif4e eukaryotic translation initiation factor 4E IEA KEGG rno:04910 NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683 		JBrowse link
G Eif4e2 eukaryotic translation initiation factor 4E family member 2 IEA KEGG rno:04910 NCBI chr 9:87,886,126...87,914,470
Ensembl chr 9:87,878,085...87,914,482 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 ISO
IEA		 PID
KEGG		 PID:200014 rno:04910 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984 		JBrowse link
G Elk1 ETS transcription factor ELK1 IEA KEGG rno:04910 NCBI chr  X:1,138,826...1,155,713
Ensembl chr  X:1,139,756...1,155,713 		JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 ISO RGD PMID:17347799 RGD:1625124 NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715 		JBrowse link
G Exoc1 exocyst complex component 1 ISO PID PID:200014 NCBI chr14:31,611,536...31,659,920
Ensembl chr14:31,611,547...31,659,914 		JBrowse link
G Exoc2 exocyst complex component 2 ISO PID PID:200014 NCBI chr17:33,506,289...33,698,246
Ensembl chr17:33,506,338...33,693,289 		JBrowse link
G Exoc3 exocyst complex component 3 ISO PID PID:200014 NCBI chr 1:29,091,298...29,122,056
Ensembl chr 1:29,091,294...29,122,045 		JBrowse link
G Exoc4 exocyst complex component 4 ISO PID PID:200014 NCBI chr 4:61,807,706...62,584,316
Ensembl chr 4:61,807,761...62,585,723 		JBrowse link
G Exoc5 exocyst complex component 5 ISO PID PID:200014 NCBI chr15:22,310,682...22,355,695
Ensembl chr15:22,308,946...22,355,335 		JBrowse link
G Exoc6 exocyst complex component 6 ISO PID PID:200014 NCBI chr 1:235,314,612...235,457,824
Ensembl chr 1:235,300,369...235,457,015 		JBrowse link
G Exoc7 exocyst complex component 7 ISO
IEA		 PID
KEGG		 PID:200014 rno:04910 NCBI chr10:101,521,630...101,540,425
Ensembl chr10:101,520,927...101,540,561 		JBrowse link
G F2rl2 coagulation factor II (thrombin) receptor-like 2 ISO PID PID:200014 NCBI chr 2:26,972,054...26,977,098
Ensembl chr 2:26,972,054...26,977,098 		JBrowse link
G Fasn fatty acid synthase IEA KEGG rno:04910 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Fbp1 fructose-bisphosphatase 1 IEA KEGG rno:04910 NCBI chr17:2,207,271...2,230,076
Ensembl chr17:2,208,031...2,230,071 		JBrowse link
G Fbp2 fructose-bisphosphatase 2 IEA KEGG rno:04910 NCBI chr17:2,236,088...2,253,702
Ensembl chr17:2,236,336...2,253,698 		JBrowse link
G Flot1 flotillin 1 IEA KEGG rno:04910 NCBI chr20:2,917,864...2,927,993
Ensembl chr20:2,917,137...2,927,978 		JBrowse link
G Flot2 flotillin 2 IEA KEGG rno:04910 NCBI chr10:62,926,047...62,947,759
Ensembl chr10:62,920,665...62,947,756 		JBrowse link
G Foxo1 forkhead box O1 IEA KEGG rno:04910 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790 		JBrowse link
G Foxo3 forkhead box O3 ISO PID PID:200014 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 IEA KEGG rno:04910 NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804 		JBrowse link
G Gck glucokinase IEA KEGG rno:04910 NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995 		JBrowse link
G Grb10 growth factor receptor bound protein 10 ISO PID
RGD		 PMID:17347799 PID:200014, RGD:1625124 NCBI chr14:86,495,051...86,602,800
Ensembl chr14:86,495,054...86,602,806 		JBrowse link
G Grb14 growth factor receptor bound protein 14 ISO
IDA		 PID
RGD		 PMID:17347799 PMID:9748281 PID:200014, RGD:1625124, RGD:61620 NCBI chr 3:49,568,210...49,683,805
Ensembl chr 3:49,568,210...49,683,889 		JBrowse link
G Grb2 growth factor receptor bound protein 2 IDA
ISO
IEA		 SMPDB
KEGG
PID
RGD		 PMID:12891559 PID:200014 SMP:00391 rno:04910, RGD:1299201 NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta IEA KEGG rno:04910 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Gys1 glycogen synthase 1 IEA KEGG rno:04910 NCBI chr 1:95,915,443...95,935,292
Ensembl chr 1:95,915,443...95,935,292 		JBrowse link
G Gys2 glycogen synthase 2 IEA KEGG rno:04910 NCBI chr 4:175,365,054...175,406,228
Ensembl chr 4:175,365,054...175,406,228 		JBrowse link
G Hk1 hexokinase 1 IEA KEGG rno:04910 NCBI chr20:30,230,488...30,332,099
Ensembl chr20:30,230,486...30,332,131 		JBrowse link
G Hk2 hexokinase 2 IEA KEGG rno:04910 NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530 		JBrowse link
G Hk3 hexokinase 3 IEA KEGG rno:04910 NCBI chr17:9,596,950...9,614,847
Ensembl chr17:9,599,865...9,614,863 		JBrowse link
G Hras HRas proto-oncogene, GTPase ISO
IEA		 PID
KEGG
SMPDB		 PID:200014 SMP:00391 rno:04910 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta IEA KEGG rno:04910 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Inpp5d inositol polyphosphate-5-phosphatase D ISO
IEA		 PID
KEGG		 PID:200014 rno:04910 NCBI chr 9:88,287,680...88,392,748
Ensembl chr 9:88,287,677...88,392,746 		JBrowse link
G Ins1 insulin 1 ISO
IEA		 KEGG
RGD		 PMID:17347799 rno:04910, RGD:1625124 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Ins2 insulin 2 ISO
IEA		 SMPDB
KEGG
PID
RGD		 PMID:17347799 PID:200014 SMP:00391 rno:04910, RGD:1625124 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Insr insulin receptor IMP
IEP
ISO
IEA
IDA		 SMPDB
KEGG
PID
RGD		 PMID:12850498 PMID:29896241 PMID:17347799 PMID:12891559 PID:200014 SMP:00391 rno:04910, RGD:1580595, RGD:14700925, RGD:1625124, RGD:1299201 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883 		JBrowse link
G Irs1 insulin receptor substrate 1 IMP
ISO
IEA
IDA		 SMPDB
KEGG
PID
RGD		 PMID:12850498 PMID:23055040 PMID:16445997 PID:200014 SMP:00391 rno:04910, RGD:1580595, RGD:7248547, RGD:1581310 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122 		JBrowse link
G Irs2 insulin receptor substrate 2 IMP
ISO
IEA
IDA		 SMPDB
KEGG
RGD		 PMID:12850498 PMID:23055040 PMID:12891559 SMP:00391 rno:04910, RGD:1580595, RGD:7248547, RGD:1299201 NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482 		JBrowse link
G Irs3 insulin receptor substrate 3 IDA
ISO
IEA		 KEGG
RGD		 PMID:16445997 PMID:23055040 rno:04910, RGD:1581310, RGD:7248547 NCBI chr12:19,053,148...19,055,286
Ensembl chr12:19,053,148...19,055,286 		JBrowse link
G Irs4 insulin receptor substrate 4 IEA
ISO		 KEGG
RGD		 PMID:23055040 rno:04910, RGD:7248547 NCBI chr  X:105,344,020...105,360,004 JBrowse link
G Kras KRAS proto-oncogene, GTPase IEA KEGG rno:04910 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Lipe lipase E, hormone sensitive type IEA KEGG rno:04910 NCBI chr 1:80,965,612...80,984,313
Ensembl chr 1:80,965,627...80,984,310 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 IEA
ISO		 KEGG
SMPDB		 SMP:00391 rno:04910 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 IEA
ISO		 KEGG
SMPDB		 SMP:00391 rno:04910 NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 IEA
ISO		 KEGG
SMPDB		 SMP:00391 rno:04910 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk10 mitogen activated protein kinase 10 IEA KEGG rno:04910 NCBI chr14:6,497,662...6,790,109
Ensembl chr14:6,497,707...6,786,201 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 IEA KEGG rno:04910 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 IEA KEGG rno:04910 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 IEA KEGG rno:04910 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mknk1 MAPK interacting serine/threonine kinase 1 IEA KEGG rno:04910 NCBI chr 5:129,318,128...129,357,641
Ensembl chr 5:129,318,170...129,357,639 		JBrowse link
G Mknk2 MAPK interacting serine/threonine kinase 2 IEA KEGG rno:04910 NCBI chr 7:9,039,771...9,050,832
Ensembl chr 7:9,039,728...9,050,827 		JBrowse link
G Mtor mechanistic target of rapamycin kinase IEA KEGG rno:04910 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Nck1 NCK adaptor protein 1 ISO PID PID:200014 NCBI chr 8:101,018,610...101,079,237
Ensembl chr 8:101,018,702...101,079,300 		JBrowse link
G Nck2 NCK adaptor protein 2 ISO PID PID:200014 NCBI chr 9:45,713,979...45,840,330
Ensembl chr 9:45,714,883...45,840,307 		JBrowse link
G Nras NRAS proto-oncogene, GTPase IEA KEGG rno:04910 NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626 		JBrowse link
G Pard6a par-6 family cell polarity regulator alpha ISO PID PID:200014 NCBI chr19:33,589,531...33,591,900
Ensembl chr19:33,589,542...33,591,900 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 IEA KEGG rno:04910 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191 		JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) IEA KEGG rno:04910 NCBI chr15:29,027,891...29,036,729
Ensembl chr15:29,027,894...29,037,283 		JBrowse link
G Pde3a phosphodiesterase 3A IEA KEGG rno:04910 NCBI chr 4:174,172,804...174,443,944
Ensembl chr 4:174,172,868...174,438,274 		JBrowse link
G Pde3b phosphodiesterase 3B IEA KEGG rno:04910 NCBI chr 1:168,606,762...168,770,078
Ensembl chr 1:168,607,022...168,769,334 		JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 ISO
IEA		 PID
SMPDB
KEGG		 PID:200014 SMP:00391 rno:04910 NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623 		JBrowse link
G Phka1 phosphorylase kinase regulatory subunit alpha 1 IEA KEGG rno:04910 NCBI chr  X:67,601,302...67,738,504
Ensembl chr  X:67,601,302...67,738,455 		JBrowse link
G Phka2 phosphorylase kinase regulatory subunit alpha 2 IEA KEGG rno:04910 NCBI chr  X:34,170,959...34,293,498
Ensembl chr  X:34,171,323...34,293,466 		JBrowse link
G Phkb phosphorylase kinase regulatory subunit beta IEA KEGG rno:04910 NCBI chr19:21,013,719...21,210,671
Ensembl chr19:21,025,733...21,210,633 		JBrowse link
G Phkg1 phosphorylase kinase catalytic subunit gamma 1 IEA KEGG rno:04910 NCBI chr12:26,838,822...26,854,547
Ensembl chr12:26,838,968...26,852,850 		JBrowse link
G Phkg2 phosphorylase kinase catalytic subunit gamma 2 IEA KEGG rno:04910 NCBI chr 1:182,184,362...182,197,124
Ensembl chr 1:182,184,650...182,197,124 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha ISO
IEA		 PID
KEGG		 PID:200014 rno:04910 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta IEA KEGG rno:04910 NCBI chr 8:99,594,600...99,699,772
Ensembl chr 8:99,594,644...99,699,663 		JBrowse link
G Pik3cd phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta IEA KEGG rno:04910 NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma ISO SMPDB SMP:00391 NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043 		JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 IDA
IEA
ISO		 KEGG
PID
RGD		 PMID:12891559 PID:200014 rno:04910, RGD:1299201 NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631 		JBrowse link
G Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 IEA KEGG rno:04910 NCBI chr16:18,665,517...18,674,067
Ensembl chr16:18,665,457...18,674,065 		JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 IEA KEGG rno:04910 NCBI chr 5:129,700,925...129,772,591
Ensembl chr 5:129,701,229...129,772,583 		JBrowse link
G Pik3r5 phosphoinositide-3-kinase, regulatory subunit 5 IEA KEGG rno:04910 NCBI chr10:53,132,585...53,200,663
Ensembl chr10:53,132,603...53,199,374 		JBrowse link
G Pik3r6 phosphoinositide-3-kinase, regulatory subunit 6 ISO SMPDB SMP:00391 NCBI chr10:53,203,930...53,255,229
Ensembl chr10:53,205,496...53,255,243 		JBrowse link
G Pklr pyruvate kinase L/R IEA KEGG rno:04910 NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha IEA KEGG rno:04910 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Ppp1ca protein phosphatase 1 catalytic subunit alpha IEA KEGG rno:04910 NCBI chr 1:201,485,117...201,488,734
Ensembl chr 1:201,485,085...201,497,327 		JBrowse link
G Ppp1cb protein phosphatase 1 catalytic subunit beta IEA KEGG rno:04910 NCBI chr 6:23,958,813...23,992,841
Ensembl chr 6:23,960,998...23,992,824 		JBrowse link
G Ppp1cc protein phosphatase 1 catalytic subunit gamma IEA KEGG rno:04910 NCBI chr12:34,383,072...34,400,553
Ensembl chr12:34,383,072...34,400,553 		JBrowse link
G Ppp1r3a protein phosphatase 1, regulatory subunit 3A IEA KEGG rno:04910 NCBI chr 4:42,937,353...42,980,195
Ensembl chr 4:42,939,599...42,980,638 		JBrowse link
G Ppp1r3b protein phosphatase 1, regulatory subunit 3B IEA KEGG rno:04910 NCBI chr16:56,830,011...56,842,395
Ensembl chr16:56,829,660...56,842,406 		JBrowse link
G Ppp1r3c protein phosphatase 1, regulatory subunit 3C IEA KEGG rno:04910 NCBI chr 1:234,460,958...234,465,961
Ensembl chr 1:234,460,652...234,465,961 		JBrowse link
G Ppp1r3d protein phosphatase 1, regulatory subunit 3D IEA KEGG rno:04910 NCBI chr 3:165,502,384...165,505,455
Ensembl chr 3:165,502,384...165,505,455 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 IEA KEGG rno:04910 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978 		JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 IEA KEGG rno:04910 NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543 		JBrowse link
G Prkab1 protein kinase AMP-activated non-catalytic subunit beta 1 IEA KEGG rno:04910 NCBI chr12:40,588,140...40,598,673
Ensembl chr12:40,588,211...40,598,661 		JBrowse link
G Prkab2 protein kinase AMP-activated non-catalytic subunit beta 2 IEA KEGG rno:04910 NCBI chr 2:185,257,218...185,272,846
Ensembl chr 2:185,257,213...185,269,872 		JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha IEA KEGG rno:04910 NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430 		JBrowse link
G Prkacb protein kinase cAMP-activated catalytic subunit beta IEA KEGG rno:04910 NCBI chr 2:235,636,878...235,726,928
Ensembl chr 2:235,636,885...235,726,198 		JBrowse link
G Prkag1 protein kinase AMP-activated non-catalytic subunit gamma 1 IEA KEGG rno:04910 NCBI chr 7:129,963,105...129,980,532
Ensembl chr 7:129,963,105...129,980,561 		JBrowse link
G Prkag2 protein kinase AMP-activated non-catalytic subunit gamma 2 IEA KEGG rno:04910 NCBI chr 4:10,010,890...10,252,155
Ensembl chr 4:10,010,890...10,252,142 		JBrowse link
G Prkag3 protein kinase AMP-activated non-catalytic subunit gamma 3 IEA KEGG rno:04910 NCBI chr 9:76,295,715...76,304,959
Ensembl chr 9:76,295,715...76,304,959 		JBrowse link
G Prkar1a protein kinase cAMP-dependent type I regulatory subunit alpha IEA KEGG rno:04910 NCBI chr10:94,621,042...94,639,534
Ensembl chr10:94,620,039...94,639,041 		JBrowse link
G Prkar2a protein kinase cAMP-dependent type II regulatory subunit alpha IEA KEGG rno:04910 NCBI chr 8:109,393,189...109,458,832
Ensembl chr 8:109,395,833...109,455,628 		JBrowse link
G Prkar2b protein kinase cAMP-dependent type II regulatory subunit beta IEA KEGG rno:04910 NCBI chr 6:48,563,659...48,653,933
Ensembl chr 6:48,563,662...48,653,933 		JBrowse link
G Prkca protein kinase C, alpha ISO RGD PMID:17347799 RGD:1625124 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012 		JBrowse link
G Prkcb protein kinase C, beta ISO RGD PMID:17347799 RGD:1625124 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536 		JBrowse link
G Prkcg protein kinase C, gamma ISO RGD PMID:17347799 RGD:1625124 NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384 		JBrowse link
G Prkci protein kinase C, iota ISO
IEA		 PID
KEGG		 PID:200014 rno:04910 NCBI chr 2:112,321,919...112,382,305
Ensembl chr 2:112,321,929...112,382,352 		JBrowse link
G Prkcq protein kinase C, theta ISO RGD PMID:17347799 RGD:1625124 NCBI chr17:67,246,394...67,379,049
Ensembl chr17:67,246,394...67,378,704 		JBrowse link
G Prkcz protein kinase C, zeta ISO
IEA		 PID
KEGG		 PID:200014 rno:04910 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367 		JBrowse link
G Prkx protein kinase cAMP-dependent X-linked catalytic subunit IEA KEGG rno:04910 NCBI chr  X:41,823,349...41,866,844
Ensembl chr  X:41,823,355...41,866,669 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 IMP
IEA
ISO
IDA		 KEGG
PID
RGD		 PMID:12850498 PMID:7711057 PMID:17347799 PID:200014 rno:04910, RGD:1580595, RGD:2293185, RGD:1625124 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504 		JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 IDA
ISO		 PID
RGD		 PMID:12891559 PMID:7711057 PID:200014, RGD:1299201, RGD:2293185 NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925 		JBrowse link
G Ptpra protein tyrosine phosphatase, receptor type, A ISO PID PID:200014 NCBI chr 3:117,650,146...117,759,744
Ensembl chr 3:117,650,183...117,759,728 		JBrowse link
G Ptprf protein tyrosine phosphatase, receptor type, F ISO
IEA
IDA		 KEGG
RGD		 PMID:17347799 PMID:7711057 rno:04910, RGD:1625124, RGD:2293185 NCBI chr 5:131,741,959...131,824,000
Ensembl chr 5:131,742,754...131,810,023 		JBrowse link
G Pygb glycogen phosphorylase B IEA KEGG rno:04910 NCBI chr 3:139,611,724...139,658,521
Ensembl chr 3:139,611,749...139,663,553 		JBrowse link
G Pygl glycogen phosphorylase L IEA KEGG rno:04910 NCBI chr 6:88,697,598...88,740,260
Ensembl chr 6:88,697,593...88,740,310 		JBrowse link
G Pygm glycogen phosphorylase, muscle associated IEA KEGG rno:04910 NCBI chr 1:203,690,550...203,705,369
Ensembl chr 1:203,690,533...203,705,368 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase IEA
ISO		 KEGG
SMPDB		 SMP:00391 rno:04910 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317 		JBrowse link
G Rapgef1 Rap guanine nucleotide exchange factor 1 IEA KEGG rno:04910 NCBI chr 3:12,898,349...13,016,234
Ensembl chr 3:12,898,266...13,013,984 		JBrowse link
G Rasa1 RAS p21 protein activator 1 ISO PID PID:200014 NCBI chr 2:15,857,704...15,940,757
Ensembl chr 2:15,857,980...15,940,854 		JBrowse link
G Rheb Ras homolog, mTORC1 binding IEA KEGG rno:04910 NCBI chr 4:10,278,970...10,320,160
Ensembl chr 4:10,279,370...10,320,160 		JBrowse link
G Rhoq ras homolog family member Q ISO
IEA		 PID
KEGG		 PID:200014 rno:04910 NCBI chr 6:7,613,632...7,652,047 JBrowse link
G Rps6 ribosomal protein S6 IEA KEGG rno:04910 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 ISO
IEA		 PID
KEGG		 PID:200014 rno:04910 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Rps6kb2 ribosomal protein S6 kinase B2 IEA KEGG rno:04910 NCBI chr 1:201,451,265...201,458,096
Ensembl chr 1:201,451,265...201,458,078 		JBrowse link
G Rptor regulatory associated protein of MTOR, complex 1 IEA KEGG rno:04910 NCBI chr10:104,878,487...105,176,986
Ensembl chr10:104,878,487...105,176,983 		JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 ISO PID PID:200014 NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283 		JBrowse link
G Sh2b2 SH2B adaptor protein 2 ISO
IEA		 KEGG
PID
RGD		 PMID:17347799 PID:200014 rno:04910, RGD:1625124 NCBI chr12:20,427,057...20,456,845
Ensembl chr12:20,429,043...20,456,844 		JBrowse link
G Shc1 SHC adaptor protein 1 ISO
IEA		 SMPDB
KEGG
PID
RGD		 PMID:17347799 PID:200014 SMP:00391 rno:04910, RGD:1625124 NCBI chr 2:174,837,937...174,849,538
Ensembl chr 2:174,837,930...174,849,536 		JBrowse link
G Shc2 SHC adaptor protein 2 IEA KEGG rno:04910 NCBI chr 7:10,066,705...10,088,926
Ensembl chr 7:10,066,705...10,088,926 		JBrowse link
G Shc3 SHC adaptor protein 3 IEA KEGG rno:04910 NCBI chr17:13,652,247...13,772,710
Ensembl chr17:13,651,202...13,772,710 		JBrowse link
G Shc4 SHC adaptor protein 4 IEA KEGG rno:04910 NCBI chr 3:112,880,598...112,974,216
Ensembl chr 3:112,880,600...112,974,366 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 IEA
ISO		 KEGG
SMPDB		 SMP:00391 rno:04910 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Socs1 suppressor of cytokine signaling 1 ISO
IEA		 KEGG
RGD		 PMID:17010638 rno:04910, RGD:1625125 NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383 		JBrowse link
G Socs2 suppressor of cytokine signaling 2 IEA KEGG rno:04910 NCBI chr 7:30,006,360...30,045,161
Ensembl chr 7:30,008,578...30,043,548 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 ISO
IEA		 KEGG
RGD		 PMID:17010638 rno:04910, RGD:1625125 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787 		JBrowse link
G Socs4 suppressor of cytokine signaling 4 IEA KEGG rno:04910 NCBI chr15:20,523,406...20,537,889
Ensembl chr15:20,523,183...20,542,494 		JBrowse link
G Socs6 suppressor of cytokine signaling 6 ISO RGD PMID:17010638 RGD:1625125 NCBI chr18:82,111,866...82,139,193
Ensembl chr18:82,111,827...82,139,219 		JBrowse link
G Socs7 suppressor of cytokine signaling 7 ISO RGD PMID:17010638 RGD:1625125 NCBI chr10:82,352,159...82,388,829
Ensembl chr10:82,351,680...82,388,830 		JBrowse link
G Sorbs1 sorbin and SH3 domain containing 1 ISO
IEA		 PID
KEGG		 PID:200014 rno:04910 NCBI chr 1:239,107,882...239,330,276
Ensembl chr 1:239,108,777...239,330,169 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 IDA
ISO
IEA		 SMPDB
KEGG
PID
RGD		 PMID:12891559 PID:200014 SMP:00391 rno:04910, RGD:1299201 NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107 		JBrowse link
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 IDA
IEA		 KEGG
RGD		 PMID:12891559 rno:04910, RGD:1299201 NCBI chr 6:88,042,966...88,156,140
Ensembl chr 6:88,042,966...88,156,692 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 IEA KEGG rno:04910 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Trip10 thyroid hormone receptor interactor 10 ISO
IEA		 PID
KEGG		 PID:200014 rno:04910 NCBI chr 9:2,133,085...2,147,795
Ensembl chr 9:2,133,671...2,147,799 		JBrowse link
G Tsc1 TSC complex subunit 1 IEA KEGG rno:04910 NCBI chr 3:11,969,547...12,018,591
Ensembl chr 3:11,979,729...12,015,674 		JBrowse link
G Tsc2 TSC complex subunit 2 IEA KEGG rno:04910 NCBI chr10:13,621,135...13,655,773
Ensembl chr10:13,621,136...13,655,951 		JBrowse link
altered insulin signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ins2 insulin 2 ISO RGD PMID:9809695 RGD:2313694 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Insr insulin receptor ISO RGD PMID:9809695 RGD:2313694 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 6092
    regulatory pathway 3871
      homeostasis pathway 1773
        energy homeostasis pathway 431
          insulin signaling pathway 159
            altered insulin signaling pathway 2
paths to the root