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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:ACTH-secreting pituitary adenoma
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Accession:DOID:7004 term browser browse the term
Definition:A functioning pituitary adenoma that characterized by excess cortisol a primary cause of Cushing's syndrome. (DO)
Synonyms:exact_synonym: ACTH Producing Pituitary Adenoma;   ACTH-Secreting Pituitary Adenomas;   ACTH-producing pituitary adenomas;   CUSHING DISEASE, PITUITARY;   Corticotroph Adenoma;   Corticotroph Adenomas;   PITA4;   PITUITARY ADENOMA 4, ACTH-SECRETING;   PITUITARY ADENOMA, ACTH-SECRETING, SOMATIC;   Pituitary Corticotropin Secreting Adenoma;   corticotropinoma;   pituitary corticotropin-secreting adenomas
 primary_id: MESH:D049913
 alt_id: OMIM:219090
 xref: EFO:1000066;   GARD:12867;   NCI:C7462
For additional species annotation, visit the Alliance of Genome Resources.


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ACTH-secreting pituitary adenoma term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aip aryl-hydrocarbon receptor-interacting protein ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: PITUITARY ADENOMA 4, ACTH-SECRETING		 CTD
ClinVar		 PMID:17360484 PMID:18381572 PMID:19366855 PMID:20506337 PMID:20530095 More... NCBI chr 1:201,407,287...201,419,220
Ensembl chr 1:201,407,288...201,419,122 		JBrowse link
G Avpr1b arginine vasopressin receptor 1B ISO RGD PMID:23884782 RGD:14700670 NCBI chr13:43,046,960...43,057,110
Ensembl chr13:43,046,267...43,057,792 		JBrowse link
G Bmp4 bone morphogenetic protein 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:16195406 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306 		JBrowse link
G Usp8 ubiquitin specific peptidase 8 ISO CTD Direct Evidence: marker/mechanism CTD
OMIM		 PMID:25485838 NCBI chr 3:113,962,136...114,009,683
Ensembl chr 3:113,962,164...114,009,666 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 21089
    disease of cellular proliferation 7659
      benign neoplasm 2212
        cell type benign neoplasm 1915
          adenoma 724
            pituitary adenoma 29
              functioning pituitary adenoma 19
                ACTH-secreting pituitary adenoma 4
                  Nelson syndrome 0
Path 2
Term Annotations click to browse term
  disease 21089
    disease of anatomical entity 18156
      nervous system disease 13996
        Nervous System Neoplasms 1606
          Central Nervous System Neoplasms 1393
            Brain Neoplasms 1348
              brain cancer 735
                supratentorial cancer 463
                  diencephalic neoplasm 62
                    thalamic neoplasm 62
                      hypothalamic neoplasm 62
                        Pituitary Neoplasms 60
                          pituitary gland benign neoplasm 29
                            pituitary adenoma 29
                              functioning pituitary adenoma 19
                                ACTH-secreting pituitary adenoma 4
                                  Nelson syndrome 0
paths to the root