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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:olfactory neuroblastoma
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Accession:DOID:369 term browser browse the term
Definition:A malignant olfactory neuroblastoma arising from the olfactory epithelium of the superior nasal cavity and cribriform plate. It is uncommon (3% of nasal tumors) and rarely is associated with the production of excess hormones (e.g., SIADH, Cushing Syndrome). It has a high propensity for multiple local recurrences and bony metastases. (From Holland et al., Cancer Medicine, 3rd ed, p1245; J Laryngol Otol 1998 Jul;112(7):628-33)
Synonyms:exact_synonym: Aesthesioneuroblastoma;   Esthesioneuroblastoma;   Esthesioneuroblastomas;   Olfactory Esthesioneuroblastomas;   Olfactory Neuroblastomas;   aesthesioneuroblastomas;   asthesioneuroblastoma;   esthesioneuroepithelioma;   olfactory esthesioneuroblastoma;   paranasal sinus nasal cavity esthesioneuroblastoma;   paranasal sinus olfactory neuroblastoma
 primary_id: MESH:D018304
 xref: GARD:2197;   NCI:C3789;   NCI:C6016
For additional species annotation, visit the Alliance of Genome Resources.



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olfactory neuroblastoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hif1a hypoxia inducible factor 1 subunit alpha severity ISO protein:increased expression:neuroblastoma (human) RGD PMID:18431543 RGD:8694471 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18156
    disease of anatomical entity 17531
      nervous system disease 13193
        peripheral nervous system disease 3018
          neuropathy 2804
            cranial nerve disease 528
              olfactory nerve disease 1
                olfactory neuroblastoma 1
                  nasal cavity olfactory neuroblastoma 0
Path 2
Term Annotations click to browse term
  disease 18156
    disease of cellular proliferation 7339
      Neoplasms by Site 6969
        Nervous System Neoplasms 1763
          Central Nervous System Neoplasms 1386
            Brain Neoplasms 1342
              brain cancer 729
                supratentorial cancer 462
                  cerebrum cancer 410
                    malignant astrocytoma 406
                      astroblastoma 250
                        Primitive Neuroectodermal Tumors 159
                          Primitive Peripheral Neuroectodermal Tumors 92
                            neuroblastoma 91
                              olfactory neuroblastoma 1
                                nasal cavity olfactory neuroblastoma 0
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