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RGD uses the Human Disease Ontology (DO, for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:aggressive NK-cell leukemia
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Accession:DOID:1035 term browser browse the term
Definition:A leukemia that is characterized by the systemic proliferation of NK cells closely associated with Epstein-Barr virus and that is located_in the peripheral blood, bone marrow, liver, and spleen. (DO)
Synonyms:exact_synonym: aggressive NK-cell leukaemia;   large granular lymphocyte leukemia, NK-cell type;   natural killer cell leukaemia;   natural killer cell leukemia
 xref: ICD10CM:C94.8;   NCI:C8647
For additional species annotation, visit the Alliance of Genome Resources.

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Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16058
    disease of anatomical entity 15305
      hematopoietic system disease 1646
        leukocyte disease 499
          aggressive NK-cell leukemia 0
Path 2
Term Annotations click to browse term
  disease 16058
    disease of cellular proliferation 5918
      cancer 4242
        organ system cancer 4067
          immune system cancer 612
            lymphatic system cancer 612
              lymphoma 533
                lymphoid leukemia 293
                  aggressive NK-cell leukemia 0
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.