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EXPERIMENTAL CONDITION - ANNOTATIONS

The Clinical Measurement Ontology (CMO), Measurement Methods Ontology (MMO), and Experimental Condition Ontology (XCO) are currently being developed at the Rat Genome Database. For more information about these vocabularies please see Shimoyama et al. Three ontologies to define phenotype measurement data. Front Genet. 2012;3:87. Epub 2012 May 28 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:spironolactone
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Accession:XCO:0000627 term browser browse the term
Definition:Any condition in which the main influencing factor isspironolactone, a potassium-sparing diuretic that competitively inhibits mineralocorticoid receptors in the distal convoluted tubule to promote sodium and water excretion and potassium retention. Spironolactone is indicated to treat a number of conditions including heart failure, edema, hyperaldosteronism, adrenal hyperplasia, hypertension, and nephrotic syndrome.
Synonyms:exact_synonym: DB00421
 xref: CHEBI:9241

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  experimental condition 0
    chemical 0
      chemical with specified function 0
        diuretic 0
          spironolactone 0
Path 2
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  experimental condition 0
    chemical 0
      chemical with specified function 0
        inhibitor 0
          receptor antagonist 0
            mineralocorticoid receptor antagonist 0
              spironolactone 0
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