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CROSS-SPECIES ANATOMY - ANNOTATIONS

The Basic subset of the UBERON integrated, cross-species anatomy ontology is downloaded weekly from http://berkeleybop.org/ontologies/uberon/basic.obo. For more information about this ontology see the "About" page on the UBERON website at http://uberon.github.io/about.html.
Term:undifferentiated genital tubercle
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Accession:UBERON:0005876 term browser browse the term
Definition:The embryonic anlage of the external genitalia, which emerges as paired swellings ventral to the cloacal membrane, is proposed to be derived from all three germ layers, and gives rise to the penis, clitoris, scrotum, labia, and foreskin.
Comment:[homology-note] "In mammalian embryos, male and female external genitalia develop from the genital tubercle.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000583", ontology="VHOG", source="DOI:10.1242/dev.036830 Seifert AW, Yamaguchi T, Cohn MJ, Functional and phylogenetic analysis shows that Fgf8 is a marker of genital induction in mammals but is not required for external genital development. Development (2009)", source="http://bgee.unil.ch/"}; [taxon-note] "All amniotes studied to date initiate external genital development with the formation of paired genital swellings. In mammals, archosaurs, and turtles, these swellings merge to form a single genital tubercle, the precursor of the penis and clitoris[PMID:24960313]"; [taxon-note] "GT development is indistinguishable in male and female mouse embryos until approximately E16, when the urethral plate begins to be masculinized to form the penile urethra, marking the beginning of an androgen-dependent phase of sexual differentiation[MP:0011771]"; [taxon-note] "todo - add taxon constraints"
Synonyms:related_synonym: genital tubercle;   phallic tubercle;   tuberculum genitale;   tuberculum phallicum
 xref: EHDAA2:0000705;   EHDAA:5925;   EMAPA:17382;   FMA:302888;   SCTID:308798005;   VHOG:0000583;   Wikipedia:Genital_tubercle


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Term paths to the root
Path 1
Term Annotations click to browse term
  UBERON ontology 0
    anatomical entity 0
      material anatomical entity 0
        developing anatomical structure 0
          embryonic structure 0
            undifferentiated genital tubercle 0
              clitoris + 0
              differentiated genital tubercle + 0
              genital swelling + 0
              penis + 0
              preputial swelling + 0
Path 2
Term Annotations click to browse term
  UBERON ontology 0
    anatomical entity 0
      material anatomical entity 0
        anatomical structure 0
          multicellular anatomical structure 0
            multicellular organism 0
              embryo 0
                embryonic structure 0
                  embryonic tissue 0
                    germ layer / neural crest 0
                      germ layer 0
                        mesoderm 0
                          mesoderm-derived structure 0
                            lateral plate mesoderm 0
                              somatopleure 0
                                undifferentiated genital tubercle 0
                                  clitoris + 0
                                  differentiated genital tubercle + 0
                                  genital swelling + 0
                                  penis + 0
                                  preputial swelling + 0
paths to the root