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CROSS-SPECIES ANATOMY - ANNOTATIONS

The Basic subset of the UBERON integrated, cross-species anatomy ontology is downloaded weekly from http://berkeleybop.org/ontologies/uberon/basic.obo. For more information about this ontology see the "About" page on the UBERON website at http://uberon.github.io/about.html.
Term:non-neural ectoderm
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Accession:UBERON:0005497 term browser browse the term
Comment:Gene notes: One of the first genes to be expressed in nonneural ectoderm in amphioxus is BMP2/4 (Panopoulou et al. 1998). BMP2/4 homologues appear to have a very ancient role in distinguishing neural from nonneural ectoderm; in Drosophila as well as in amphioxus and vertebrates, BMP2/4 homologues are expressed in nonneural ectoderm and function in distinguishing neural from nonneural ectoderm (Francois & Bier, 1995 ; Sasai et al. 1995 ; Wilson & Hemmati-Brivanlou, 1995; Panopoulou et al. 1998). A change in level of BMP2/4 from very high in nonneural ectoderm to low in neural ectoderm appears to be a key factor in development of neural crest (Baker & Bronner-Fraser,1997a,1997b;Erickson&Reedy,1998;Marchantet al.1998 ;Selleck et al. 1998).; [development-note] "After gastrulation, neural crest cells are specified at the border of the neural plate and the non-neural ectoderm."; [homology-note] "In the early gastrula of vertebrates, factors from the organizer (e.g. noggin, chordin, and follistatin in Xenopus) antagonize the epidermalizing factor bone morphogenetic protein 4 (BMP4), thus dividing the epiblast into neuroectoderm. In Drosophila, decapentaplegic, the homologue of BMP4, interacts similarly with the protein short gastrulation, the homologue of chordin. Thus, a comparable molecular mechanism for distinguishing non-neural ectoderm from neural ectoderm was probably present in the common ancestor of all bilaterally symmetrical animals.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0001372", ontology="VHOG", source="DOI:10.1016/S0959-4388(99)00003-3 Holland LZ and Holland ND, Chordate origins of the vertebrate central nervous system. Current Opinion in Neurobiology (1999)", source="http://bgee.unil.ch/"}
Synonyms:narrow_synonym: epidermal ectoderm;   epithelial ectoderm
 related_synonym: surface ectoderm;   ventral ectoderm
 xref: EFO:0003643;   EHDAA:257;   EMAPA:16074;   RETIRED_EHDAA2:0001273;   TAO:0001178;   VHOG:0001372;   XAO:0004091;   ZFA:0001178
 cyclic_relationship: mutually_spatially_disjoint_with mutually_spatially_disjoint_with UBERON:0002346


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Term paths to the root
Path 1
Term Annotations click to browse term
  UBERON ontology 0
    anatomical entity 0
      material anatomical entity 0
        anatomical structure 0
          ectoderm-derived structure 0
            non-neural ectoderm 0
              adenohypophyseal placode + 0
              preplacodal ectoderm + 0
Path 2
Term Annotations click to browse term
  UBERON ontology 0
    anatomical entity 0
      material anatomical entity 0
        anatomical structure 0
          multicellular anatomical structure 0
            multicellular organism 0
              embryo 0
                embryonic structure 0
                  embryonic tissue 0
                    germ layer / neural crest 0
                      germ layer 0
                        ectoderm 0
                          ectoderm-derived structure 0
                            non-neural ectoderm 0
                              adenohypophyseal placode + 0
                              preplacodal ectoderm + 0
paths to the root