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CROSS-SPECIES ANATOMY - ANNOTATIONS

The Basic subset of the UBERON integrated, cross-species anatomy ontology is downloaded weekly from http://berkeleybop.org/ontologies/uberon/basic.obo. For more information about this ontology see the "About" page on the UBERON website at http://uberon.github.io/about.html.

Term:apical ectodermal ridge
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Accession:UBERON:0004356 term browser browse the term
Definition:Multilayered ectodermal region at the distal tip of a limb or fin bud necessary for the proper development of the underlying mesenchyme[MP,modified]. Along with the zone of polarizing activity, it is a crucial organizing region during limb development[WP].
Comment:[function-note] "maintaining mesenchyme in plastic proliferating state; maintaining expression of A-P axis genes; interacting with D-V proteins. Genes: AER induced by Fgf10 in mesenchyme. AER secretes Fgf8, which stimulates mitosis in the mesenchyme causing Fgf10 production - positive feedback loop"; [taxon-note] "The AER of tetrapods regresses after specification of skeletal progenitors, the AER of teleosts form an elongating fin fold" xsd:string {source="PMID:20574421"}
Synonyms:exact_synonym: apical epidermal ridge
 related_synonym: AER;   crista ectodermalis apicalis
 xref: AAO:0010760;   EMAPA:32744;   NCI:C34109;   TAO:0002146;   UMLS:C1516037;   Wikipedia:Apical_ectodermal_ridge;   XAO:0004121;   ZFA:0001702
 axiom_lost: relationship loss: subclass proliferative region (TAO:0000098)[TAO]" xsd:string {date_retrieved="2012-08-14", external_class="TAO:0002146", ontology="TAO



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Term paths to the root
Path 1
Term Annotations click to browse term
  UBERON ontology 0
    anatomical entity 0
      material anatomical entity 0
        developing anatomical structure 0
          embryonic structure 0
            apical ectodermal ridge 0
              apical ectodermal ridge dorsal fin 0
              apical ectodermal ridge median fin fold 0
              apical ectodermal ridge pelvic fin 0
              footplate apical ectodermal ridge 0
              handplate apical ectodermal ridge 0
              pectoral appendage apical ectodermal ridge + 0
              pelvic appendage apical ectodermal ridge + 0
Path 2
Term Annotations click to browse term
  UBERON ontology 0
    anatomical entity 0
      material anatomical entity 0
        anatomical structure 0
          multicellular anatomical structure 0
            multicellular organism 0
              embryo 0
                embryonic structure 0
                  embryonic tissue 0
                    germ layer / neural crest 0
                      germ layer 0
                        ectoderm 0
                          apical ectodermal ridge 0
                            apical ectodermal ridge dorsal fin 0
                            apical ectodermal ridge median fin fold 0
                            apical ectodermal ridge pelvic fin 0
                            footplate apical ectodermal ridge 0
                            handplate apical ectodermal ridge 0
                            pectoral appendage apical ectodermal ridge + 0
                            pelvic appendage apical ectodermal ridge + 0
paths to the root