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CROSS-SPECIES ANATOMY - ANNOTATIONS

The Basic subset of the UBERON integrated, cross-species anatomy ontology is downloaded weekly from http://berkeleybop.org/ontologies/uberon/basic.obo. For more information about this ontology see the "About" page on the UBERON website at http://uberon.github.io/about.html.
Term:optic vesicle
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Accession:UBERON:0004128 term browser browse the term
Definition:The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup[GO]. Portion of tissue that is comprised of neuroepitheium which has pinched off from the anterior neural keel and will form the optic cup[ZFA].
Comment:Genes: Six3, Pax6, Rx1 are expressed together in the tip of the neural plate [ISBN:9780878932504 "Developmental Biology"]. Development notes: During subsequent develop- ment, the optic vesicle invaginates and becomes a two-layered structure with an inner neural retina and outer retinal pigment epithelium. As soon as the developing optic vesicle makes contact with the overlying ectoderm, it induces the ectoderm to thicken and form the lens placode [PMID:16496288]; [homology-note] "(...) an essentially similar sequence of events occurs during the embryonic development of the vertebrate eye. The eye initially develops as a single median evagination of the diencephalon that soon bifurcates to form the paired optic vesicles.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000165", ontology="VHOG", source="ISBN:978-0030223693 Liem KF, Bemis WE, Walker WF, Grande L, Functional Anatomy of the Vertebrates: An Evolutionary Perspective (2001) p.429", source="http://bgee.unil.ch/"}
Synonyms:related_synonym: evagination;   eye vesicle;   ocular vesicle;   optic vesicles
 xref: AAO:0011039;   EHDAA2:0001320;   EMAPA:16540;   FMA:293357;   NCI:C34236;   SCTID:362864008;   TAO:0000050;   UMLS:C0231106;   VHOG:0000165;   Wikipedia:Optic_vesicles;   XAO:0000228;   ZFA:0000050


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Term paths to the root
Path 1
Term Annotations click to browse term
  UBERON ontology 0
    anatomical entity 0
      material anatomical entity 0
        anatomical structure 0
          ectoderm-derived structure 0
            optic vesicle 0
              iris + 0
              optic cup + 0
Path 2
Term Annotations click to browse term
  UBERON ontology 0
    anatomical entity 0
      material anatomical entity 0
        anatomical structure 0
          multicellular anatomical structure 0
            multicellular organism 0
              embryo 0
                embryonic structure 0
                  embryonic tissue 0
                    germ layer / neural crest 0
                      germ layer 0
                        ectoderm 0
                          ectoderm-derived structure 0
                            neurectoderm 0
                              presumptive neural plate 0
                                neural plate 0
                                  pre-chordal neural plate 0
                                    eye primordium 0
                                      immature eye 0
                                        optic vesicle 0
                                          iris + 0
                                          optic cup + 0
paths to the root