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CROSS-SPECIES ANATOMY - ANNOTATIONS

The Basic subset of the UBERON integrated, cross-species anatomy ontology is downloaded weekly from http://berkeleybop.org/ontologies/uberon/basic.obo. For more information about this ontology see the "About" page on the UBERON website at http://uberon.github.io/about.html.
Term:prostate bud
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Accession:UBERON:0003820 term browser browse the term
Definition:A region of the fetal urogenital sinus epithelium destined to become the prostate[GO].
Comment:[function-note] "AR activation releases instructive signals from UGM that acts on UGS epithelium (UGE) to stimulate cell proliferation, form prostate ductal progenitors (prostatic buds), and regulate cell adhesion dynamics to permit prostatic bud outgrowth. There are three phases of prostatic budding: (1) the specification phase, when instructive developmental cues define where buds will form in the UGS, (2) the initiation phase, when prostatic buds begin to form, and (3) the elongation phase, when proliferation, cell adhesion, and cell migration coordinate outgrowth of prostatic buds into UGM. Timing of prostatic bud formation and the quantity and pattern of buds that are formed in the UGS are strictly regulated [3, 4]. The position of prostatic buds as they emerge from the UGS in utero determines the arrangement of prostate ducts in adulthood.[PMID:18977204]"
Synonyms:exact_synonym: prostate ductal progenitor;   prostatic bud
 related_synonym: prostate gland bud;   prostate primordium
 xref: EMAPA:36141


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Term paths to the root
Path 1
Term Annotations click to browse term
  UBERON ontology 0
    anatomical entity 0
      material anatomical entity 0
        developing anatomical structure 0
          anlage 0
            prostate field 0
              prostate bud 0
                prostate duct 0
                prostate gland + 0
Path 2
Term Annotations click to browse term
  UBERON ontology 0
    anatomical entity 0
      material anatomical entity 0
        anatomical structure 0
          multicellular anatomical structure 0
            multicellular organism 0
              embryo 0
                embryonic structure 0
                  epiblast (generic) 0
                    germ layer / neural crest 0
                      germ layer 0
                        endoderm 0
                          endoderm-derived structure 0
                            endo-epithelium 0
                              anal membrane endodermal component 0
                                embryonic cloacal epithelium 0
                                  urogenital sinus epithelium 0
                                    prostate field 0
                                      prostate bud 0
                                        prostate duct 0
                                        prostate gland + 0
paths to the root