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CROSS-SPECIES ANATOMY - ANNOTATIONS

The Basic subset of the UBERON integrated, cross-species anatomy ontology is downloaded weekly from http://berkeleybop.org/ontologies/uberon/basic.obo. For more information about this ontology see the "About" page on the UBERON website at http://uberon.github.io/about.html.
Term:ciliary marginal zone
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Accession:UBERON:0003065 term browser browse the term
Definition:Region at the periphery of the retina where retinal stem cells are located. After 60 hpf, the CMZ is the source of most retinal growth.[Wehman et al, 2005].
Comment:[homology-note] "The retina of all vertebrates develops via similar mechanisms. Toward the end of retinal histogenesis, proliferating progenitors and newly generated cells are confined to peripheral regions of the retina. In fish and amphibians, this region is maintained after embryonic development and becomes the CMZ (ciliary margin zone). A CMZ exists in birds but compared to that of fish and amphibians this region produces much less new retina as the globe of the eye expands postnatally. At least some of the molecular mechanisms that regulate the addition of new cells in this zone appear to have been conserved from fish to birds.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000088", ontology="VHOG", source="DOI:10.1159/000057571 Reh TA, Fischer AJ, Stem cells in the vertebrate retina. Brain Behav Evol (2001)", source="http://bgee.unil.ch/"}
Synonyms:exact_synonym: peripheral growth zone;   retinal ciliary marginal zone
 related_synonym: CMZ;   circumferential germinal zone;   retinal proliferative zone
 xref: AAO:0010342;   EFO:0003668;   TAO:0001289;   VHOG:0000088;   XAO:0000086;   ZFA:0001289


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Term paths to the root
Path 1
Term Annotations click to browse term
  UBERON ontology 0
    anatomical entity 0
      material anatomical entity 0
        anatomical structure 0
          ectoderm-derived structure 0
            ciliary marginal zone 0
Path 2
Term Annotations click to browse term
  UBERON ontology 0
    anatomical entity 0
      material anatomical entity 0
        anatomical structure 0
          multicellular anatomical structure 0
            multicellular organism 0
              embryo 0
                embryonic structure 0
                  epiblast (generic) 0
                    germ layer / neural crest 0
                      germ layer 0
                        ectoderm 0
                          ectoderm-derived structure 0
                            neurectoderm 0
                              presumptive neural plate 0
                                neural plate 0
                                  pre-chordal neural plate 0
                                    eye primordium 0
                                      immature eye 0
                                        optic vesicle 0
                                          optic cup 0
                                            camera-type eye 0
                                              eyeball of camera-type eye 0
                                                posterior segment of eyeball 0
                                                  retina 0
                                                    ciliary marginal zone 0
paths to the root