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CROSS-SPECIES ANATOMY - ANNOTATIONS

The Basic subset of the UBERON integrated, cross-species anatomy ontology is downloaded weekly from http://berkeleybop.org/ontologies/uberon/basic.obo. For more information about this ontology see the "About" page on the UBERON website at http://uberon.github.io/about.html.
Term:spleen
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Accession:UBERON:0002106 term browser browse the term
Definition:The organ that functions to filter blood and to store red corpuscles and platelets.
Comment:[function-note] "It synthesizes antibodies in its white pulp and removes, from blood and lymph node circulation, antibody-coated bacteria along with antibody-coated blood cells"; [homology-note] "With the advent of clonal selection, the accumulation and segregation of T and B cells in specialized organs for antigen presentation became necessary, and indeed the spleen is found in all jawed vertebrates, but not in agnathans or invertebrates.[well established][VHOG]" xsd:string {date_retrieved="2012-09-17", external_class="VHOG:0000120", ontology="VHOG", source="ISBN:978-0781765190 Paul WE, Fundamental Immunology (2008) p.94", source="http://bgee.unil.ch/"}; [taxon-note] "In humans, it is located in the left upper quadrant of the abdomen. It removes old red blood cells and holds a reserve in case of hemorrhagic shock, especially in animals like horses (not in humans), while recycling iron"; [taxon-note] "Neither hagfish nor lampreys possess what might be considered a discrete and condensed spleen. Hagfish possess dispersed lymphoid tissue within the submucosa of the intestine (96) associated with the portal vein (97), whereas lymphoid tissue is associated with the typhlosole portion of the intestine in lampreys (96)" xsd:string {source="PMID:20959416"}
Synonyms:related_synonym: lien
 xref: AAO:0010395;   BTO:0001281;   CALOHA:TS-0956;   EFO:0000869;   EMAPA:18767;   EV:0100055;   FMA:7196;   GAID:1289;   MA:0000141;   MAT:0000085;   MESH:D013154;   MIAA:0000085;   NCI:C12432;   SCTID:181279003;   TAO:0000436;   UMLS:C0037993;   VHOG:0000120;   Wikipedia:Spleen;   XAO:0000328;   ZFA:0000436;   galen:Spleen
 relational_adjective: lienal
 external_ontology: present_in_taxon NCBITaxon:9606
 relational_adjective: splenic


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Term paths to the root
Path 1
Term Annotations click to browse term
  UBERON ontology 0
    anatomical entity 0
      material anatomical entity 0
        anatomical structure 0
          mesoderm-derived structure 0
            spleen primordium 0
              spleen 0
                Schweigger-Seidel sheath 0
                hilum of spleen 0
                marginal zone of spleen 0
                parenchyma of spleen + 0
                spleen capsule 0
                spleen perifollicular zone 0
                spleen smooth muscle 0
                splenic arteriole + 0
                vasculature of spleen 0
Path 2
Term Annotations click to browse term
  UBERON ontology 0
    anatomical entity 0
      material anatomical entity 0
        anatomical structure 0
          multicellular anatomical structure 0
            multicellular organism 0
              embryo 0
                embryonic structure 0
                  embryonic tissue 0
                    germ layer / neural crest 0
                      germ layer 0
                        mesoderm 0
                          mesoderm-derived structure 0
                            lateral plate mesoderm 0
                              blood island 0
                                hematopoietic system 0
                                  hemopoietic organ 0
                                    spleen 0
                                      Schweigger-Seidel sheath 0
                                      hilum of spleen 0
                                      marginal zone of spleen 0
                                      parenchyma of spleen + 0
                                      spleen capsule 0
                                      spleen perifollicular zone 0
                                      spleen smooth muscle 0
                                      splenic arteriole + 0
                                      vasculature of spleen 0
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