PATHWAY ONTOLOGY - ANNOTATIONS
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml ).
Term: mitochondrial iron-sulfur cluster protein biogenesis pathway
Accession: PW:0002635
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Definition: The mitochondrial pathway consists of the synthesis of [2Fe-2S] clusters on scaffold proteins, cluster transfer and formation of mitochondrial [2Fe-2S] proteins, and the synthesis of 4Fe-4S] clusters and the formation of [4Fe-4S] proteins. The first two steps are required for the mitochondrial export and the biogenesis of cytosolic and nuclear Fe-S proteins. This arm of the pathway is usually referred to as the 'core'.
Synonyms: related_synonym: Mitochondrial iron-sulfur cluster biogenesis
alt_id: Reactome:R-HSA-1362409
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Bola3
bolA family member 3
ISO
RGD
PMID:25245479
RGD:11554190
NCBI chr 4:115,853,350...115,862,797
Ensembl chr 4:115,853,350...115,862,797
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Fdx1
ferredoxin 1
ISO
RGD
PMID:25245479
RGD:11554190
NCBI chr 8:52,268,536...52,287,344
Ensembl chr 8:52,268,536...52,287,414
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Fdx2
ferredoxin 2
ISO
RGD
PMID:25245479
RGD:11554190
NCBI chr 8:19,604,916...19,609,832
Ensembl chr 8:19,604,916...19,609,849
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Fdxr
ferredoxin reductase
ISO
RGD
PMID:25245479
RGD:11554190
NCBI chr10:100,507,863...100,516,649
Ensembl chr10:100,507,865...100,516,658
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Glrx5
glutaredoxin 5
ISO
RGD
PMID:25245479
RGD:11554190
NCBI chr 6:123,988,461...123,998,545
Ensembl chr 6:123,988,134...123,998,545
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Hscb
HscB mitochondrial iron-sulfur cluster co-chaperone
ISO
RGD
PMID:25245479
RGD:11554190
NCBI chr12:45,821,527...45,831,902
Ensembl chr12:45,821,555...45,831,909
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Hspa9
heat shock protein family A (Hsp70) member 9
ISO
RGD
PMID:25245479
RGD:11554190
NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292
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Iba57
iron-sulfur cluster assembly factor IBA57
ISO
RGD
PMID:25245479
RGD:11554190
NCBI chr10:43,942,017...43,950,807
Ensembl chr10:43,942,017...43,950,807
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Isca1
iron-sulfur cluster assembly 1
ISO
RGD
PMID:25245479
RGD:11554190
NCBI chr17:4,905,291...4,917,955
Ensembl chr17:4,905,287...4,917,955
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Isca2
iron-sulfur cluster assembly 2
ISO
RGD
PMID:25245479
RGD:11554190
NCBI chr 6:104,418,509...104,420,019
Ensembl chr 6:104,418,454...104,420,045
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Iscu
iron-sulfur cluster assembly enzyme
ISO
RGD
PMID:25245479
RGD:11554190
NCBI chr12:42,852,305...42,858,150
Ensembl chr12:42,852,305...42,858,150
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Lyrm4
LYR motif containing 4
ISO
RGD
PMID:25245479
RGD:11554190
NCBI chr17:28,746,457...28,861,849
Ensembl chr17:28,746,469...28,861,750
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Nfs1
NFS1 cysteine desulfurase
ISO
RGD
PMID:25245479
RGD:11554190
NCBI chr 3:144,637,309...144,659,660
Ensembl chr 3:144,637,309...144,659,666
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Nfu1
NFU1 iron-sulfur cluster scaffold
ISO
RGD
PMID:25245479
RGD:11554190
NCBI chr 4:119,458,981...119,480,162
Ensembl chr 4:119,459,061...119,480,373
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Nubpl
NUBP iron-sulfur cluster assembly factor like
ISO
RGD
PMID:25245479
RGD:11554190
NCBI chr 6:69,559,278...69,781,254
Ensembl chr 6:69,559,291...69,781,253
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all