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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:mitochondrial iron-sulfur cluster protein biogenesis pathway
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Accession:PW:0002635 term browser browse the term
Definition:The mitochondrial pathway consists of the synthesis of [2Fe-2S] clusters on scaffold proteins, cluster transfer and formation of mitochondrial [2Fe-2S] proteins, and the synthesis of 4Fe-4S] clusters and the formation of [4Fe-4S] proteins. The first two steps are required for the mitochondrial export and the biogenesis of cytosolic and nuclear Fe-S proteins. This arm of the pathway is usually referred to as the 'core'.
Synonyms:related_synonym: Mitochondrial iron-sulfur cluster biogenesis
 alt_id: Reactome:R-HSA-1362409
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mitochondrial iron-sulfur cluster protein biogenesis pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BOLA3 bolA family member 3 ISO RGD PMID:25245479 RGD:11554190 NCBI chr2A:74,207,111...74,219,705
Ensembl chr2A:75,715,161...75,727,622 		JBrowse link
G FDX1 ferredoxin 1 ISO RGD PMID:25245479 RGD:11554190 NCBI chr11:105,311,613...105,345,414 JBrowse link
G FDX2 ferredoxin 2 ISO RGD PMID:25245479 RGD:11554190 NCBI chr19:9,860,316...9,866,442
Ensembl chr19:10,526,287...10,532,152 		JBrowse link
G FDXR ferredoxin reductase ISO RGD PMID:25245479 RGD:11554190 NCBI chr17:68,808,123...68,818,642
Ensembl chr17:74,364,343...74,374,852 		JBrowse link
G GLRX5 glutaredoxin 5 ISO RGD PMID:25245479 RGD:11554190 NCBI chr14:76,162,541...76,172,291 JBrowse link
G HSCB HscB mitochondrial iron-sulfur cluster cochaperone ISO RGD PMID:25245479 RGD:11554190 NCBI chr22:9,811,294...9,826,245
Ensembl chr22:27,512,564...27,527,914 		JBrowse link
G HSPA9 heat shock protein family A (Hsp70) member 9 ISO RGD PMID:25245479 RGD:11554190 NCBI chr 5:133,934,859...133,955,048
Ensembl chr 5:140,064,207...140,084,551 		JBrowse link
G IBA57 iron-sulfur cluster assembly factor IBA57 ISO RGD PMID:25245479 RGD:11554190 NCBI chr 1:203,566,902...203,577,857 JBrowse link
G ISCA1 iron-sulfur cluster assembly 1 ISO RGD PMID:25245479 RGD:11554190 NCBI chr 9:57,410,328...57,428,477
Ensembl chr 9:85,467,145...85,485,107 		JBrowse link
G ISCA2 iron-sulfur cluster assembly 2 ISO RGD PMID:25245479 RGD:11554190 NCBI chr14:55,046,821...55,048,602
Ensembl chr14:73,894,694...73,896,444 		JBrowse link
G ISCU iron-sulfur cluster assembly enzyme ISO RGD PMID:25245479 RGD:11554190 NCBI chr12:106,132,987...106,140,879
Ensembl chr12:109,529,162...109,537,053 		JBrowse link
G LYRM4 LYR motif containing 4 ISO RGD PMID:25245479 RGD:11554190 NCBI chr 6:4,887,010...5,096,384
Ensembl chr 6:5,127,918...5,279,038 		JBrowse link
G NFS1 NFS1 cysteine desulfurase ISO RGD PMID:25245479 RGD:11554190 NCBI chr20:31,994,509...32,026,776 JBrowse link
G NFU1 NFU1 iron-sulfur cluster scaffold ISO RGD PMID:25245479 RGD:11554190 NCBI chr2A:69,438,979...69,480,470
Ensembl chr2A:70,559,872...70,600,301 		JBrowse link
G NUBPL NUBP iron-sulfur cluster assembly factor, mitochondrial ISO RGD PMID:25245479 RGD:11554190 NCBI chr14:12,338,341...12,628,346 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4064
    classic metabolic pathway 1016
      metabolic pathway of cofactors, vitamins, nutrients 239
        iron-sulfur cluster protein biogenesis pathway 26
          mitochondrial iron-sulfur cluster protein biogenesis pathway 15
Path 2
Term Annotations click to browse term
  pathway 4064
    regulatory pathway 2507
      homeostasis pathway 1306
        inorganic chemical homeostasis pathway 292
          metal homeostasis pathway 200
            iron homeostasis pathway 62
              iron utilization pathway 37
                iron-sulfur cluster protein biogenesis pathway 26
                  mitochondrial iron-sulfur cluster protein biogenesis pathway 15
paths to the root