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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:iron-sulfur cluster protein biogenesis pathway
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Accession:PW:0002634 term browser browse the term
Definition:The steps involved in the assembly and delivery of iron-sulfur (Fe-S) clusters (ISC) to Fe-S proteins. The mitochondrial ISC and the connected cytosolic assembly (CIA) pathways provide for the biogenesis of all Fe-S proteins. The Fe-S proteins participate in a broad range of important cellular processes.

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cytosolic iron-sulfur cluster protein assembly pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ciao1 cytosolic iron-sulfur assembly component 1 ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chrNW_004936744:359,234...364,649
Ensembl chrNW_004936744:359,258...363,585 		JBrowse link
G Ciao2a cytosolic iron-sulfur assembly component 2A ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chrNW_004936471:24,547,862...24,568,003
Ensembl chrNW_004936471:24,548,235...24,567,792 		JBrowse link
G Ciao2b cytosolic iron-sulfur assembly component 2B ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chrNW_004936475:17,181,766...17,184,266
Ensembl chrNW_004936475:17,181,536...17,184,271 		JBrowse link
G Ciao3 cytosolic iron-sulfur assembly component 3 ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chrNW_004936501:277,525...286,929
Ensembl chrNW_004936501:277,518...286,932 		JBrowse link
G Ciapin1 cytokine induced apoptosis inhibitor 1 ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chrNW_004936475:9,485,214...9,502,619 JBrowse link
G Mms19 MMS19 homolog, cytosolic iron-sulfur assembly component ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chrNW_004936636:2,191,748...2,221,027
Ensembl chrNW_004936636:2,191,774...2,220,650 		JBrowse link
G Ndor1 NADPH dependent diflavin oxidoreductase 1 ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chrNW_004936669:773,494...782,286
Ensembl chrNW_004936669:773,472...782,292 		JBrowse link
G Nubp1 NUBP iron-sulfur cluster assembly factor 1, cytosolic ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chrNW_004936530:8,970,963...8,985,925
Ensembl chrNW_004936530:8,971,380...8,986,033 		JBrowse link
G Nubp2 NUBP iron-sulfur cluster assembly factor 2, cytosolic ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chrNW_004936694:2,208,102...2,211,910
Ensembl chrNW_004936694:2,208,518...2,211,653 		JBrowse link
mitochondrial iron-sulfur cluster export pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb7 ATP binding cassette subfamily B member 7 ISO RGD PMID:25245479 RGD:11554190 NCBI chrNW_004936683:1,224,703...1,326,761
Ensembl chrNW_004936683:1,222,450...1,326,765 		JBrowse link
G Gfer growth factor, augmenter of liver regeneration ISO RGD PMID:25245479 RGD:11554190 NCBI chrNW_004936694:2,051,362...2,053,812
Ensembl chrNW_004936694:2,051,325...2,053,818 		JBrowse link
mitochondrial iron-sulfur cluster protein biogenesis pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bola3 bolA family member 3 ISO RGD PMID:25245479 RGD:11554190 NCBI chrNW_004936556:424,044...434,678
Ensembl chrNW_004936556:426,110...435,139 		JBrowse link
G Fdx1 ferredoxin 1 ISO RGD PMID:25245479 RGD:11554190 NCBI chrNW_004936612:3,878,179...3,905,678
Ensembl chrNW_004936612:3,874,748...3,905,825 		JBrowse link
G Fdxr ferredoxin reductase ISO RGD PMID:25245479 RGD:11554190 NCBI chrNW_004936594:215,165...223,715
Ensembl chrNW_004936594:215,155...223,771 		JBrowse link
G Hscb HscB mitochondrial iron-sulfur cluster cochaperone ISO RGD PMID:25245479 RGD:11554190 NCBI chrNW_004936657:2,848,282...2,860,115 JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 ISO RGD PMID:25245479 RGD:11554190 NCBI chrNW_004936531:7,702,186...7,716,428
Ensembl chrNW_004936531:7,702,695...7,716,380 		JBrowse link
G Iba57 iron-sulfur cluster assembly factor IBA57 ISO RGD PMID:25245479 RGD:11554190 NCBI chrNW_004936864:50,033...63,540
Ensembl chrNW_004936864:49,889...63,481 		JBrowse link
G Isca1 iron-sulfur cluster assembly 1 ISO RGD PMID:25245479 RGD:11554190 NCBI chrNW_004936680:1,673,666...1,689,646
Ensembl chrNW_004936680:1,673,666...1,689,635 		JBrowse link
G Isca2 iron-sulfur cluster assembly 2 ISO RGD PMID:25245479 RGD:11554190 NCBI chrNW_004936488:3,676,752...3,678,741
Ensembl chrNW_004936488:3,676,677...3,678,949 		JBrowse link
G Iscu iron-sulfur cluster assembly enzyme ISO RGD PMID:25245479 RGD:11554190 NCBI chrNW_004936769:492,024...498,587
Ensembl chrNW_004936769:491,530...498,692 		JBrowse link
G LOC101962614 ferredoxin-2, mitochondrial ISO RGD PMID:25245479 RGD:11554190 NCBI chrNW_004936659:640,243...650,350
Ensembl chrNW_004936659:645,191...650,246
Ensembl chrNW_004936659:645,191...650,246 		JBrowse link
G Lyrm4 LYR motif containing 4 ISO RGD PMID:25245479 RGD:11554190 NCBI chrNW_004936534:7,205,538...7,350,114
Ensembl chrNW_004936534:7,205,614...7,350,525 		JBrowse link
G Nfs1 NFS1 cysteine desulfurase ISO RGD PMID:25245479 RGD:11554190 NCBI chrNW_004936561:5,136,692...5,158,266 JBrowse link
G Nfu1 NFU1 iron-sulfur cluster scaffold ISO RGD PMID:25245479 RGD:11554190 NCBI chrNW_004936491:13,680,669...13,712,924
Ensembl chrNW_004936491:13,679,629...13,712,988 		JBrowse link
G Nubpl NUBP iron-sulfur cluster assembly factor, mitochondrial ISO RGD PMID:25245479 RGD:11554190 NCBI chrNW_004936494:6,141,444...6,365,537
Ensembl chrNW_004936494:6,141,476...6,363,830 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 3945
    classic metabolic pathway 974
      metabolic pathway of cofactors, vitamins, nutrients 227
        iron-sulfur cluster protein biogenesis pathway 25
          cytosolic iron-sulfur cluster protein assembly pathway 9
          mitochondrial iron-sulfur cluster export pathway 2
          mitochondrial iron-sulfur cluster protein biogenesis pathway 14
Path 2
Term Annotations click to browse term
  pathway 3945
    regulatory pathway 2439
      homeostasis pathway 1275
        inorganic chemical homeostasis pathway 288
          metal homeostasis pathway 197
            iron homeostasis pathway 61
              iron utilization pathway 36
                iron-sulfur cluster protein biogenesis pathway 25
                  cytosolic iron-sulfur cluster protein assembly pathway 9
                  mitochondrial iron-sulfur cluster export pathway 2
                  mitochondrial iron-sulfur cluster protein biogenesis pathway 14
paths to the root