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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:iron-sulfur cluster protein biogenesis pathway
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Accession:PW:0002634 term browser browse the term
Definition:The steps involved in the assembly and delivery of iron-sulfur (Fe-S) clusters (ISC) to Fe-S proteins. The mitochondrial ISC and the connected cytosolic assembly (CIA) pathways provide for the biogenesis of all Fe-S proteins. The Fe-S proteins participate in a broad range of important cellular processes.


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cytosolic iron-sulfur cluster protein assembly pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CIAO1 cytosolic iron-sulfur assembly component 1 ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chr 3:46,960,880...46,967,003
Ensembl chr 3:46,960,881...46,966,635 		JBrowse link
G CIAO2A cytosolic iron-sulfur assembly component 2A ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chr 1:107,951,618...107,969,306
Ensembl chr 1:107,951,646...107,969,298 		JBrowse link
G CIAO2B cytosolic iron-sulfur assembly component 2B ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chr 6:27,610,469...27,612,617
Ensembl chr 6:27,610,470...27,612,592 		JBrowse link
G CIAO3 cytosolic iron-sulfur assembly component 3 ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chr 3:41,042,672...41,050,013
Ensembl chr 3:41,042,702...41,050,012 		JBrowse link
G CIAPIN1 cytokine induced apoptosis inhibitor 1 ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chr 6:19,356,065...19,373,085
Ensembl chr 6:19,356,069...19,373,060 		JBrowse link
G MMS19 MMS19 homolog, cytosolic iron-sulfur assembly component ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chr14:108,853,038...108,886,587
Ensembl chr14:108,853,025...108,886,579 		JBrowse link
G NDOR1 NADPH dependent diflavin oxidoreductase 1 ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192
G NUBP1 NUBP iron-sulfur cluster assembly factor 1, cytosolic ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chr 3:32,311,774...32,340,120
Ensembl chr 3:32,311,779...32,340,034 		JBrowse link
G NUBP2 NUBP iron-sulfur cluster assembly factor 2, cytosolic ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chr 3:40,178,417...40,184,646
Ensembl chr 3:40,178,417...40,186,551 		JBrowse link
mitochondrial iron-sulfur cluster export pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB7 ATP binding cassette subfamily B member 7 ISO RGD PMID:25245479 RGD:11554190 NCBI chr  X:60,186,559...60,313,098
Ensembl chr  X:60,186,814...60,313,064 		JBrowse link
G GFER growth factor, augmenter of liver regeneration ISO RGD PMID:25245479 RGD:11554190 NCBI chr 3:39,981,938...39,984,451
Ensembl chr 3:39,981,940...39,984,991 		JBrowse link
mitochondrial iron-sulfur cluster protein biogenesis pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BOLA3 bolA family member 3 ISO RGD PMID:25245479 RGD:11554190 NCBI chr 3:68,883,194...68,895,750 JBrowse link
G FDX1 ferredoxin 1 ISO RGD PMID:25245479 RGD:11554190 NCBI chr 9:38,376,147...38,399,026
Ensembl chr 9:38,375,984...38,404,832 		JBrowse link
G FDXR ferredoxin reductase ISO RGD PMID:25245479 RGD:11554190 NCBI chr12:6,372,224...6,382,769
Ensembl chr12:6,372,009...6,382,769 		JBrowse link
G GLRX5 glutaredoxin 5 ISO RGD PMID:25245479 RGD:11554190 NCBI chr 7:116,787,346...116,797,477
Ensembl chr 7:116,787,432...116,800,554 		JBrowse link
G HSCB HscB mitochondrial iron-sulfur cluster cochaperone ISO RGD PMID:25245479 RGD:11554190 NCBI chr14:45,967,460...45,980,632
Ensembl chr14:45,967,502...45,980,622 		JBrowse link
G HSPA9 heat shock protein family A (Hsp70) member 9 ISO RGD PMID:25245479 RGD:11554190 NCBI chr 2:140,515,239...140,532,164
Ensembl chr 2:140,515,253...140,531,857 		JBrowse link
G IBA57 iron-sulfur cluster assembly factor IBA57 ISO RGD PMID:25245479 RGD:11554190 NCBI chr 2:51,276,352...51,287,572
Ensembl chr 2:51,276,335...51,293,544 		JBrowse link
G ISCA2 iron-sulfur cluster assembly 2 ISO RGD PMID:25245479 RGD:11554190 NCBI chr 7:97,740,479...97,746,491
Ensembl chr 7:97,740,491...97,743,911 		JBrowse link
G ISCU iron-sulfur cluster assembly enzyme ISO RGD PMID:25245479 RGD:11554190 NCBI chr14:42,216,103...42,222,570
Ensembl chr14:42,216,111...42,222,711 		JBrowse link
G LOC100513185 iron-sulfur cluster assembly 1 homolog, mitochondrial pseudogene ISO RGD PMID:25245479 RGD:11554190 NCBI chr16:70,893,220...70,893,762 JBrowse link
G LYRM4 LYR motif containing 4 ISO RGD PMID:25245479 RGD:11554190 NCBI chr 7:3,034,846...3,193,123
Ensembl chr 7:3,070,470...3,192,922 		JBrowse link
G NFS1 NFS1 cysteine desulfurase ISO RGD PMID:25245479 RGD:11554190 NCBI chr17:39,000,659...39,029,179
Ensembl chr17:39,000,644...39,029,185 		JBrowse link
G NFU1 NFU1 iron-sulfur cluster scaffold ISO RGD PMID:25245479 RGD:11554190 NCBI chr 3:72,983,075...73,013,227
Ensembl chr 3:72,983,136...73,024,663 		JBrowse link
G NUBPL NUBP iron-sulfur cluster assembly factor, mitochondrial ISO RGD PMID:25245479 RGD:11554190 NCBI chr 7:67,785,652...68,028,561
Ensembl chr 7:67,784,639...68,028,552 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4041
    classic metabolic pathway 1013
      metabolic pathway of cofactors, vitamins, nutrients 239
        iron-sulfur cluster protein biogenesis pathway 25
          cytosolic iron-sulfur cluster protein assembly pathway 9
          mitochondrial iron-sulfur cluster export pathway 2
          mitochondrial iron-sulfur cluster protein biogenesis pathway 14
Path 2
Term Annotations click to browse term
  pathway 4041
    regulatory pathway 2489
      homeostasis pathway 1301
        inorganic chemical homeostasis pathway 288
          metal homeostasis pathway 198
            iron homeostasis pathway 61
              iron utilization pathway 36
                iron-sulfur cluster protein biogenesis pathway 25
                  cytosolic iron-sulfur cluster protein assembly pathway 9
                  mitochondrial iron-sulfur cluster export pathway 2
                  mitochondrial iron-sulfur cluster protein biogenesis pathway 14
paths to the root