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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:iron-sulfur cluster protein biogenesis pathway
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Accession:PW:0002634 term browser browse the term
Definition:The steps involved in the assembly and delivery of iron-sulfur (Fe-S) clusters (ISC) to Fe-S proteins. The mitochondrial ISC and the connected cytosolic assembly (CIA) pathways provide for the biogenesis of all Fe-S proteins. The Fe-S proteins participate in a broad range of important cellular processes.

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cytosolic iron-sulfur cluster protein assembly pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ciao1 cytosolic iron-sulfur assembly component 1 ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chrNW_004624749:2,344,833...2,350,986
Ensembl chrNW_004624749:2,344,743...2,351,358 		JBrowse link
G Ciao2a cytosolic iron-sulfur assembly component 2A ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chrNW_004624781:8,467,682...8,485,677
Ensembl chrNW_004624781:8,467,683...8,485,677 		JBrowse link
G Ciao3 cytosolic iron-sulfur assembly component 3 ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chrNW_004624913:1,538,561...1,553,409
Ensembl chrNW_004624913:1,538,546...1,553,415 		JBrowse link
G Ciapin1 cytokine induced apoptosis inhibitor 1 ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chrNW_004624746:28,630,662...28,647,182
Ensembl chrNW_004624746:28,630,774...28,647,182 		JBrowse link
G Mms19 MMS19 homolog, cytosolic iron-sulfur assembly component ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chrNW_004624737:9,117,767...9,150,185
Ensembl chrNW_004624737:9,118,127...9,150,130 		JBrowse link
G Ndor1 NADPH dependent diflavin oxidoreductase 1 ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chrNW_004624760:738,110...746,417
Ensembl chrNW_004624760:737,583...746,357 		JBrowse link
G Nubp1 NUBP iron-sulfur cluster assembly factor 1, cytosolic ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chrNW_004624824:8,024,459...8,040,353
Ensembl chrNW_004624824:8,024,575...8,040,364 		JBrowse link
G Nubp2 NUBP iron-sulfur cluster assembly factor 2, cytosolic ISO RGD PMID:25245479 PMID:25583461 RGD:11554190 RGD:11554192 NCBI chrNW_004624913:465,097...469,663
Ensembl chrNW_004624913:465,894...469,389 		JBrowse link
mitochondrial iron-sulfur cluster export pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb7 ATP binding cassette subfamily B member 7 ISO RGD PMID:25245479 RGD:11554190 NCBI chrNW_004624836:5,605,901...5,769,488
Ensembl chrNW_004624836:5,605,831...5,766,275 		JBrowse link
G Gfer growth factor, augmenter of liver regeneration ISO RGD PMID:25245479 RGD:11554190 NCBI chrNW_004624913:273,126...276,353
Ensembl chrNW_004624913:273,705...275,693 		JBrowse link
mitochondrial iron-sulfur cluster protein biogenesis pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bola3 bolA family member 3 ISO RGD PMID:25245479 RGD:11554190 NCBI chrNW_004624749:29,315,884...29,326,660
Ensembl chrNW_004624749:29,316,238...29,326,943 		JBrowse link
G Fdx1 ferredoxin 1 ISO RGD PMID:25245479 RGD:11554190 NCBI chrNW_004624784:5,406,459...5,460,581 JBrowse link
G Fdx2 ferredoxin 2 ISO RGD PMID:25245479 RGD:11554190 NCBI chrNW_004624828:2,468,761...2,473,657
Ensembl chrNW_004624828:2,468,757...2,473,600 		JBrowse link
G Fdxr ferredoxin reductase ISO RGD PMID:25245479 RGD:11554190 NCBI chrNW_004624801:4,714,341...4,722,588
Ensembl chrNW_004624801:4,713,519...4,722,612 		JBrowse link
G Glrx5 glutaredoxin 5 ISO RGD PMID:25245479 RGD:11554190 NCBI chrNW_004624734:7,986,999...7,995,604
Ensembl chrNW_004624734:7,987,116...7,995,220 		JBrowse link
G Hscb HscB mitochondrial iron-sulfur cluster cochaperone ISO RGD PMID:25245479 RGD:11554190 NCBI chrNW_004624747:5,072,708...5,094,404 JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 ISO RGD PMID:25245479 RGD:11554190 NCBI chrNW_004624743:31,324,085...31,345,681
Ensembl chrNW_004624743:31,324,085...31,345,695 		JBrowse link
G Iba57 iron-sulfur cluster assembly factor IBA57 ISO RGD PMID:25245479 RGD:11554190 NCBI chrNW_004624937:908,216...914,229
Ensembl chrNW_004624937:908,235...914,229 		JBrowse link
G Isca1 iron-sulfur cluster assembly 1 ISO RGD PMID:25245479 RGD:11554190 NCBI chrNW_004624809:11,099,483...11,114,917
Ensembl chrNW_004624809:11,099,485...11,114,917 		JBrowse link
G Isca2 iron-sulfur cluster assembly 2 ISO RGD PMID:25245479 RGD:11554190 NCBI chrNW_004624734:27,165,000...27,166,663
Ensembl chrNW_004624734:27,165,007...27,166,595 		JBrowse link
G Iscu iron-sulfur cluster assembly enzyme ISO RGD PMID:25245479 RGD:11554190 NCBI chrNW_004624747:11,808,789...11,815,269
Ensembl chrNW_004624747:11,808,640...11,816,400 		JBrowse link
G Lyrm4 LYR motif containing 4 ISO RGD PMID:25245479 RGD:11554190 NCBI chrNW_004624756:20,016,773...20,152,201
Ensembl chrNW_004624756:20,017,066...20,152,201 		JBrowse link
G Nfs1 NFS1 cysteine desulfurase ISO RGD PMID:25245479 RGD:11554190 NCBI chrNW_004624842:3,736,352...3,774,456
Ensembl chrNW_004624842:3,736,411...3,774,014 		JBrowse link
G Nfu1 NFU1 iron-sulfur cluster scaffold ISO RGD PMID:25245479 RGD:11554190 NCBI chrNW_004624762:3,887,124...3,917,406 JBrowse link
G Nubpl NUBP iron-sulfur cluster assembly factor, mitochondrial ISO RGD PMID:25245479 RGD:11554190 NCBI chrNW_004624820:562,180...767,434
Ensembl chrNW_004624820:567,217...791,817 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 3917
    classic metabolic pathway 958
      metabolic pathway of cofactors, vitamins, nutrients 222
        iron-sulfur cluster protein biogenesis pathway 25
          cytosolic iron-sulfur cluster protein assembly pathway 8
          mitochondrial iron-sulfur cluster export pathway 2
          mitochondrial iron-sulfur cluster protein biogenesis pathway 15
Path 2
Term Annotations click to browse term
  pathway 3917
    regulatory pathway 2426
      homeostasis pathway 1267
        inorganic chemical homeostasis pathway 280
          metal homeostasis pathway 194
            iron homeostasis pathway 60
              iron utilization pathway 36
                iron-sulfur cluster protein biogenesis pathway 25
                  cytosolic iron-sulfur cluster protein assembly pathway 8
                  mitochondrial iron-sulfur cluster export pathway 2
                  mitochondrial iron-sulfur cluster protein biogenesis pathway 15
paths to the root